| Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition (2004) | |||||||||||
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| The Journal Neuroscience September Mini Review Mouse Genetic Approaches Investigating Calcium Calmodulin Dependent Protein Kinase Function Plasticity and Cognition Ype Elgersma David Sweatt and Peter Giese Department Neuroscience Erasmus Medical Center Rotterdam The Netherlands Department Neuroscience Baylor College Medicine Houston Texas and Wolfson Institute for Biomedical Research University College London London United Kingdom Key words calcium calmodulin learning localization LTP NMDA phosphatase protein kinase knock out mice memory mental retardation gene targeting transgenic mice knock mice hippocampus Angelman The knock out calcium calmodulin dependent protein kinase CaMKII was the kickoff for new subfield neuroscience which mouse mutants are used tool gain insight into the molecular basis cognition and brain plasticity our review give overview the CaMKII mutants that have since been developed and summarize the key findings that these studies have provided the function CaMKII hippocampal plasticity cortical plasticity and learning and memory Furthermore discuss recent results that misregulation CaMKII function may cause the neurological symptoms Angelman syndrome CaMKII mutants investigate the physiological role CaMKII vivo several mutants have now been generated Table One group mutants was designed manipulate the level active CaMKII For instance gene targeting was used manipulate the endogenous CaMKII gene obtain null mutants that not express CaMKII protein well hete | |||||||||||
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Literaturangaben in der Publikation (2) | |||||||||||