| Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases | |||||||||||||
Abstract | |||||||||||||
| Background: Xenobiotic mediated cellular injury is thought to play a major role in the pathogenesis of pancreatic diseases. Genetic variations that reduce the expression or activity of detoxifying phase II biotransformation enzymes such as the UDP-glucuronosyltransferases might be important in this respect. Recently, a UGT1A7 low detoxification activity allele, UGT1A7*3, has been linked to pancreatic cancer and alcoholic chronic pancreatitis. | |||||||||||||
Details der Publikation | |||||||||||||
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