| BIOINFORMATICS ORIGINAL PAPER Sequence analysis Family specific rates of protein evolution (2008) | |||||||||||||||
Abstract | |||||||||||||||
| Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins. Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate. Contact: | |||||||||||||||
Details der Publikation | |||||||||||||||
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