| Evaluation of the-26G > A CC16 polymorphism in acute respiratory distress syndrome (2005) | |||||||||||||||
Abstract | |||||||||||||||
| Objective: Different risk factors are presumably involved in the pathogenesis of acute respiratory distress syndrome (ARDS) including genetic factors. Clara cell protein 16 (CC16) is a potential candidate gene for ARDS susceptibility because reduced levels of the anti-inflammatory CC16 have been observed in bronchoalveolar lavage fluids or serum of patients with different inflammatory lung diseases. Furthermore, CC16 potently inhibits phospholipase A2, which plays a major role in ARDS pathophysiology. A functional polymorphism (-26G > A) was previously identified and related to decreased CC16 levels, asthma, and asthma severity. | |||||||||||||||
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