| Improved long term prognosis after myocardial infarction 1984-1991 (1998) | |||||||||||||
Abstract | |||||||||||||
| Aims We set out to examine whether long term prognosis in terms of 2-year mortality after myocardial infarction has improved after the introduction of intravenous beta-blockers, nitroglycerin infusion, aspirin and thrombolytics, in an unselected population of patients hospitalized with a myocardial infarction. Methods and Results We investigated retrospectively 3791 acute myocardial infarctions in 3187 Go¨teborg women and men (1039 women and 2148 men), who were consecutively admitted to the coronary care unit at the O¨stra hospital during 1984–1991. Throughout this period, data were entered continuously into the coronary care unit database. Mortality data were collected through the Swedish cause-specific mortality register. The primary end-point was mortality within 2 years after the onset of the index infarction. Two-year mortality decreased from 36% in 1984 to 25% in 1991. In a Cox regression model (including myocardial infarctions up to 1993) year of hospitalization, age, diabetes mellitus, sex, prior myocardial infarction and indeterminable infarct location all had a significant impact on survival after myocardial infarct. Thrombolytic therapy and hypertension had no prognostic significance. Conclusion Against a background of radical changes in the treatment of acute myocardial infarction during 1984– 1991 we have seen decreasing in-hospital mortality as well as a substantial decrease in 2-year mortality. | |||||||||||||
Details der Publikation | |||||||||||||
| |||||||||||||