| Ca2+-independent regulation of neurosecretion by intracellular Na+ (1991) | |||||||||||||
Abstract | |||||||||||||
| While secretion from nerve endings is strictly controlled by an increase in cytoplasmic free calcium several reports suggest intracellular sodium may serve a regulatory role. Whether sodium acts directly to modulate secretion or indirectly by influencing cytoplasmic calcium dynamics is unknown. This study shows, based on parallel experiments studying [Na+]i, [Ca2+]i and vasopressin secretion, that sodium acts directly to regulate secretion in isolated nerve endings from the rat neurohypophysis. The elevation in secretion that develops is dose-dependently related to the [Na+]i and can occur in the absence of changes in [Ca2+]i.. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/29036/1/0000069.pdf | |||||||||||||
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