| Toll-like receptors (TLR) 4 and 2 regulate the innate immune response. Study of endotoxin influence in mice (2004) | |||||||||||||
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| TOLL LIKE RECEPTORS TLR AND REGULATE THE INNATE IMMUNE RESPONSE Study endotoxin influence mice KIR HAR Department Paediatrics Biocenter Oulu University Oulu OULU Abstract Finnish KIRSI HARJU TOLL LIKE RECEPTORS TLR AND REGULATE THE INNATE IMMUNE RESPONSE Study endotoxin influence mice Academic Dissertation presented with the assent the Faculty Medicine University Oulu for public discussion the Auditorium Oulu University Hospital May noon L L I U Copyright University Oulu Supervised Professor Mikko Hallman Doctor Marja Ojaniemi Doctor Virpi Glumoff Reviewed Professor Outi Vaarala Professor Olli Vainio ISBN nid ISBN PDF http herkules oulu isbn ISSN http herkules oulu issn OULU UNIVERSITY PRESS OULU Harju Kirsi Toll like receptors TLR and regulate the innate immune response Study endotoxin influence mice Department Paediatrics Biocenter Oulu University Oulu Box FIN University Oulu Finland Oulu Finland Abstract The response the innate immune system triggered through Toll like transmembrane receptors TLR that recognize variety microbial products TLR the principal mediator for Gram negative bacterial endotoxin LPS whereas TLR mediates the response Gram positive bacteria mycobacteria and yeast Stimulation TLR activates complex cascades leading first the production inflammatory mediators such proinflammatory cytokines and TNF Overproduction inflammatory cytokines well failure the activation innate immunity are detrimental the host Excess inflammatory stimulation leads septic shock wh | |||||||||||||
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