Evaluating the security of mobile agent platforms (2009)
Bürkle, A., Hertel, A., Müller, W., Wieser, M.
Mobility of software agents requires additional security measures. While the theoretical aspects of mobile agent security have been widely studied, there are few studies about the security levels of...
Co-operating miniature UAVs for surveillance and reconnaissance (2009)
Some complex application scenarios for micro UAVs call for the formation of swarms of multiple drones. In this paper a platform for the creation of such swarms is presented. It consists of modified...
A framework for agent-based human interaction support (2008)
Bürkle, A., Müller, W., Pfirrmann, U., Schenk, M.
In this paper we describe an agent-based infrastructure for multimodal perceptual systems which aims at developing and realizing computer services that are delivered to humans in an implicit and...
Towards a reference architecture for context-aware services (2008)
Bürkle, A., Müller, W., Pfirrmann, U.
This Chapter describes an infrastructure for multi-modal perceptual systems which aims at developing and realizing computer services that are delivered to humans in an implicit and unobtrusive way....
Towards a reference architecture for context-aware services (2008)
Bürkle, A., Müller, W., Pfirrmann, U.
This Chapter describes an infrastructure for multi-modal perceptual systems which aims at developing and realizing computer services that are delivered to humans in an implicit and unobtrusive way....
Lethal recessive myelin toxicity of prion protein lacking its central domain. (2007)
Baumann, F, Tolnay, M, Brabeck, C, Pahnke, J, Kloz, U, Niemann, H H, ...
PrP(C)-deficient mice expressing prion protein variants with large amino-proximal deletions (termed PrP(DeltaF)) suffer from neurodegeneration, which is rescued by full-length PrP(C). We now report...
A framework for agent-based human interaction support (2007)
Bürkle, A., Müller, W., Pfirrmann, U., Schenk, M.
In this paper we describe an agent-based infrastructure for multi-modal perceptual systems which aims at developing and realizing computer services that are delivered to humans in an implicit and...
Perceptive middleware and intelligent agents enhancing service autonomy in smart spaces (2006)
Dimakis, N., Soldatos, J., Polymenakos, L., Schenk, M., Pfirrmann, U., Bürkle, A.
The emerging ubiquitous computing services integrate numerous distributed and heterogeneous components, which incur significantly high costs for their development, maintenance and administration. In...
Evaluating mobile agent platform security (2006)
Bürkle, A., Hertel, A., Müller, W., Wieser, M.
Agent mobility requires additional security standards.While the theoretical aspects of mobile agent security have been widely studied, there are few studies about the security standards of current...
A test suite for the evaluation of mobile agent platform security (2006)
Bürkle, A., Essendorfer, B., Hertel, A., Müller, W., Wieser, M.
Agent mobility requires additional security measures. While the theoretical aspects of mobile agent security have been widely studied, there are few studies about the security levels of current agent...
An agent-based architecture for context-aware services supporting human interaction (2006)
Bürkle, A., Müller, W., Pfirrmann, U., Schenk, M., Dimakis, N., Soldatos, J., ...
In this paper we present an agent-based infrastructure, which provides integration and collaboration of autonomous, context-aware services in a heterogenous environment. Special consideration is...
Molinete, M., Vermeulen, W., Bürkle, A., Küpper, J.H., Hoeijmakers, J.H.J., ...
The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in...
Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.
Heilbronn, R, Albrecht, I, Stephan, S, Bürkle, A, Zur Hausen, H
JC virus, a human papovavirus, is the causative agent of the demyelinating brain disease progressive multifocal leucoencephalopathy (PML). PML is a rare but fatal disease which develops as a...
Poly(ADP-ribosyl)ation is a eukaryotic posttranslational modification of proteins that is strongly induced by the presence of DNA strand breaks and plays a role in DNA repair and the recovery of...
Hölscher, C, Kleinschmidt, J A, Bürkle, A
Adeno-associated virus (AAV) codes for four closely related nonstructural proteins (Rep) required for AAV DNA replication and gene regulation. In vitro studies have revealed that either Rep78 or...
Petersen, J, Dandri, M, Bürkle, A, Zhang, L, Rogler, C E
Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can...
Küpper, J H, Müller, M, Jacobson, M K, Tatsumi-Miyajima, J, Coyle, D L, Jacobson, E L, ...
Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalyzed by poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30), with NAD+ serving as the substrate. PARP is strongly...
Hölscher, C, Hörer, M, Kleinschmidt, J A, Zentgraf, H, Bürkle, A, Heilbronn, R
The adeno-associated virus (AAV) rep gene codes for a family of nonstructural proteins which are required for AAV gene regulation and DNA replication. In addition, rep has been implicated in a...
The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
Heilbronn, R, Bürkle, A, Stephan, S, Zur Hausen, H
Herpes simplex virus (HSV) induces within the host cell genome DNA amplification which can be suppressed by coinfection with adeno-associated virus (AAV). To characterize the AAV functions mediating...
Heilbronn, R, Jahn, G, Bürkle, A, Freese, U K, Fleckenstein, B, Zur Hausen, H
The human cytomegalovirus (HCMV)-induced DNA polymerase has been well characterized biochemically and functionally, but its genomic location has not yet been assigned. To identify the coding...
Molinete, M, Vermeulen, W, Bürkle, A, Küpper, J H, Hoeijmakers, J H, ...
The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in...
Hartwig, A, Asmuss, M, Ehleben, I, Herzer, U, Kostelac, D, Pelzer, A, ...
Nickel, cadmium, cobalt, and arsenic compounds are well-known carcinogens to humans and experimental animals. Even though their DNA-damaging potentials are rather weak, they interfere with the...
Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.
Heilbronn, R, Albrecht, I, Stephan, S, Bürkle, A, Zur Hausen, H
JC virus, a human papovavirus, is the causative agent of the demyelinating brain disease progressive multifocal leucoencephalopathy (PML). PML is a rare but fatal disease which develops as a...
Poly(ADP-ribosyl)ation is a eukaryotic posttranslational modification of proteins that is strongly induced by the presence of DNA strand breaks and plays a role in DNA repair and the recovery of...
Hölscher, C, Kleinschmidt, J A, Bürkle, A
Adeno-associated virus (AAV) codes for four closely related nonstructural proteins (Rep) required for AAV DNA replication and gene regulation. In vitro studies have revealed that either Rep78 or...
Petersen, J, Dandri, M, Bürkle, A, Zhang, L, Rogler, C E
Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can...
Küpper, J H, Müller, M, Jacobson, M K, Tatsumi-Miyajima, J, Coyle, D L, Jacobson, E L, ...
Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalyzed by poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30), with NAD+ serving as the substrate. PARP is strongly...
Hölscher, C, Hörer, M, Kleinschmidt, J A, Zentgraf, H, Bürkle, A, Heilbronn, R
The adeno-associated virus (AAV) rep gene codes for a family of nonstructural proteins which are required for AAV gene regulation and DNA replication. In addition, rep has been implicated in a...
The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
Heilbronn, R, Bürkle, A, Stephan, S, Zur Hausen, H
Herpes simplex virus (HSV) induces within the host cell genome DNA amplification which can be suppressed by coinfection with adeno-associated virus (AAV). To characterize the AAV functions mediating...
Heilbronn, R, Jahn, G, Bürkle, A, Freese, U K, Fleckenstein, B, Zur Hausen, H
The human cytomegalovirus (HCMV)-induced DNA polymerase has been well characterized biochemically and functionally, but its genomic location has not yet been assigned. To identify the coding...
Molinete, M, Vermeulen, W, Bürkle, A, Küpper, J H, Hoeijmakers, J H, ...
The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in...
Hartwig, A, Asmuss, M, Ehleben, I, Herzer, U, Kostelac, D, Pelzer, A, ...
Nickel, cadmium, cobalt, and arsenic compounds are well-known carcinogens to humans and experimental animals. Even though their DNA-damaging potentials are rather weak, they interfere with the...
DEK Is a Poly(ADP-Ribose) Acceptor in Apoptosis and Mediates Resistance to Genotoxic Stress▿ †
Kappes, F., Fahrer, J., Khodadoust, M. S., Tabbert, A., Strasser, C., Mor-Vaknin, N., ...
DEK is a nuclear phosphoprotein implicated in oncogenesis and autoimmunity and a major component of metazoan chromatin. The intracellular cues that control the binding of DEK to DNA and its...
Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent
Seker, H, Bertram, B, Bürkle, A, Kaina, B, Pohl, J, Koepsell, H, ...
β- D -Glucosyl-ifosfamide mustard (D 19575, glc-IPM, INN = glufosfamide) is a new agent for cancer chemotherapy. Its mode of action, which is only partly understood, was investigated at the DNA...