Wollin, L., Müller, M., Korolewitz, R., Krug, N., Braun, A., ...
Background: Inhibitory effects of roflumilast on responses characteristic of allergic asthma were investigated in a fungal asthma model in BALB/c mice. Methods: Mice were sensitized with Aspergillus...
Goris, K., Uhlenbruck, S., Schwegmann-Wessels, C., Köhl, W., Niedorf, F., Stern, M., ...
To address the initiation of virus infection in the respiratory tract, we established two culture systems for differentiated bovine airway epithelial cells (BAEC). Filter-grown BAEC differentiated...
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation (2009)
Braun, A., Varga-Szabo, D., Kleinschnitz, C., Pleines, I., Bender, M., Austinat, M., ...
Veres, T.Z., Shevchenko, M., Krasteva, G., Spies, E., Prenzler, F., Rochlitzer, S., ...
Interactions between T cells and dendritic cells in the airway mucosa precede secondary immune responses to inhaled antigen. The purpose of this study was to identify the anatomical locations where...
Veres, T.Z., Rochlitzer, S., Braun, A.
Despite recent advances in the development of anti-asthmatic medication, asthma continues to be a major health problem worldwide. The symptoms of asthmatic patients include wheezing, chest tightness,...
Wolf, S.A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., ...
Adult hippocampal neurogenesis occurs in an exceptional permissive microenvironment. Neuroimmunological mechanisms might be prominently involved in the endogenous homeostatic principles that control...
Profilin 1 is required for abscission during late cytokinesis of chondrocytes (2009)
Böttcher, R. T., Wiesner, S., Braun, A., Wimmer, R., Berna, A., Elad, N., ...
Prenzler, F., Veres, T., Holz, O., Welker, L., Mueller, M., Krug, N., ...
Using the human body field as a medium for natural interaction (2009)
In this paper we present a novel technique for integration in assistive environments, using capacitive proximity sensing to detect the presence of a human body, thus creating a medium for natural,...
Prolonged pro-inflammatory effects of ultrafine particles in the lung of allergic asthmatics (2009)
Schaumann, F., Dijkstra, D., Froemke, C., Windt, H., Karg, E., Mueller, M., ...
SP-D modulates uptake of allergen particles by pulmonary macrophages and dendritic cells (2009)
Winkler, C., Rochlitzer, S., Wedekind, A., Fischer, I., Braun, A., Mueller, M., ...
Role of pituitary adenylate cyclase-peptide receptor 1 in a murine model of allergic asthma (2009)
Lauenstein, H., Plappert, L., Rochlitzer, S., Pilzner, C., Welte, T., Krug, N., ...
Trimellitic anhydride-induced immune responses in murine and human precision-cut lung slices (2009)
Wang, L., Switalla, S., Förster, C., Krug, N., Hohlfeld, J., Braun, A., ...
Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models (2009)
Nassimi, M., Schleh, C., Hussein, R., Lübbers, K., Pohlmann, G., ...
The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) for human lung as a suitable drug delivery system (DDS). Therefore we used a human alveolar...
Braun, A., Hirsch, B., Katz, E.A., Gordon, J.M., Guter, W., Bett, A.W.
Multi-junction concentrator solar cells incorporate tunnel diodes that undergo a transition from high-conductance tunneling to low-conductance thermal diffusion behavior, typically at threshold...
Schleh, C., Muhlfeld, C., Pulskamp, K., Schmiedl, S., Nassimi, M., Lauenstein, H.D., ...
Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of...
Schleh, C., Muhlfeld, C., Pulskamp, K., Schmiedl, S., Nassimi, M., Lauenstein, H.D., ...
Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of...
Cytokine production after acute exposure of precision cut lung slices to NO2 and O3 (2009)
Switalla, S., Ritter, D., Krug, N., Knebel, J., Braun, A., Sewald, K.
Respiratory toxicology and immunotoxicology in human precision cut lung slices (PCLS) (2009)
Sewald, K., Switalla, S., Wang, L., Pfennig, O., Förster, C., Krug, N., ...
Der Markt für Eingabegeräte zeigte innerhalb der vergangenen Jahre eine spürbare Tendenz hin zu neuen Technologien, welche fortschrittliche Sensoren nutzen um menschliches Verhalten zu...
analysis in soft X-ray spectromicroscopy: finding the patterns in complex specimens.” (2008)
Chris Johnson Jacobsen, H. N. Chapman, A. Barty, S. Marchesini, A. Noy, ...
resolution ab initio three-dimensional x-ray diffraction microscopy, ” J. Opt. Soc. Am. A. 23,
Gupta, S., Fuchs, B., Schulz-Maronde, S., Heitland, A., Escher, S.E., Mack, M., ...
Modulation of leukocyte recruitment through intervention with chemokine receptors is an attractive, therapeutic strategy. Recently, we have shown that n-Nonanoyl (NNY)-CCL14 internalizes and...
Editorial: Experimental models of asthma (2008)
Braun, A., Tschernig, T., Groneberg, D.A.
Since 2002, a workshop entitled "Asthma in animal models" has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in...
Modulation of asthma and allergy by addressing toll-like receptor 2 (2008)
Toll-like receptors play an important role in innate and adaptive immunity and in balancing immune responses with tolerance. TLR2 is related to protection against allergies and allergic asthma by...
Purevdorj, E., Zscheppang, K., Hoymann, H.G., Braun, A., Mayersbach, D. Von, Brinkhaus, M.J., ...
Neuregulin is an important growth factor in fetal surfactant synthesis, and downregulation of its receptor, ErbB4, impairs fetal surfactant synthesis. We hypothesized that pulmonary ErbB4 deletion...
Nassenstein, C., Kwong, K., Taylor-Clark, T., Kollarik, M., MacGlashan, D.M., Braun, A., ...
Transient receptor potential (TRP) A1 and TRPM8 are ion channels that have been localized to afferent nociceptive nerves. These TRP channels may be of particular relevance to respiratory nociceptors...
Improved mouse models of allergy and allergic asthma - chances beyond ovalbumin (2008)
Allergic asthma is defined as a hypersensitivity reaction of the lung towards per se harmless antigens, e.g. pollen and house dust mite, accompanied with a chronic eosinophilic inflammation of the...
Hartwig, C., Tschernig, T., Mazzega, M., Braun, A., Neumann, D.
T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces...
Ex vivo testing of immune responses in precision-cut lung slices (2008)
Henjakovic, M., Sewald, K., Switalla, S., Kaiser, D., Müller, M., Veres, T.Z., ...
The aim of this study was the establishment of precision-cut lung slices (PCLS) as a suitable ex vivo alternative approach to animal experiments for investigation of immunomodulatory effects. For...
Schaumann, F., Müller, M., Braun, A., Luettig, B., Peden, B., Hohlfeld, J.M., ...
RATIONALE: Epidemiologic studies have shown that exacerbation of asthma is modulated by environmental endotoxin. High levels of endotoxin are associated with asthma symptoms and the current use of...
Influence of beta-parvin signaling on exercise-induced adaptations of skeletal muscle (2008)
Brixius, K., Thievessen, I., Chu, H., Braun, A., Moser, M., Niehoff, A., ...
Braun, A., Janousch, M., Sfeir, J., Kiviaho, Jari, Noponen, Matti, Huggins, F. E., ...
Journal of Power Sources Vol.183 Nr.2, 564 - 570
Schmalhorst, P.S., Krappmann, S., Vervecken, W., Rohde, M., Müller, M., Braus, G.H., ...
The filamentous fungus Aspergillus fumigatus is responsible for a lethal disease called invasive aspergillosis that affects immunocompromised patients. This disease, like other human fungal diseases,...
Henjakovic, M., Martin, C., Hoymann, H.G., Sewald, K., Ressmeyer, A.R., Dassow, C., ...
A wide range of industrial chemicals can induce respiratory allergic reactions. Hence, there is an urgent need for methods identifying and characterizing the biological action of chemicals in the...
Respiratory toxicology and immunotoxicology in precision cut lung slices (PCLS) (2008)
Sewald, K., Switalla, S., Henjakovic, M., Krug, N., Braun, A.
A variety of chemicals are known to cause sensitization of the respiratory tract. PCLS offer the opportunity to gain insight into lung morphology and physiology after in vitro exposure to chemicals....
Precision cut lung slices for testing of gaseous compounds (2008)
Switalla, S., Sewald, K., Ritter, D., Henjakovic, M., Krug, N., Knebel, J., ...
Determination of immunotoxicological effects induced by exposure to inhalable chemicals displays a critical point in vitro. Insolubility of respirable chemicals and difficulties to design adequate...
Henjakovic, M., Martin, C., Hoymann, H.G., Sewald, K., Ressmeyer, A.R., Dassow, C., ...
A wide range of industrial chemicals can induce respiratory allergic reactions. Hence, there is an urgent need for methods identifying and characterizing the biological action of chemicals in the...
Bavelier, D., Newman, A. J., Mukherjee, M., Hauser, P., Kemeny, S., Braun, A., ...
Short-term memory (STM), or the ability to hold verbal information in mind for a few seconds, is known to rely on the integrity of a frontoparietal network of areas. Here, we used functional magnetic...
Johanning, M., Braun, A., Timoney, N., Elman, V., Neuhauser, W., Wunderlich, Chr.
Individual electrodynamically trapped and laser cooled ions are addressed in frequency space using radio-frequency radiation in the presence of a static magnetic field gradient. In addition, an...
Resonance enhanced isotope-selective photoionization of YbI for ion trap loading (2007)
Braun, A., Paape, Chr., Balzer, Chr., Neuhauser, W., Wunderlich, Chr.
Neutral Ytterbium (YbI) and singly ionized Ytterbium (YbII) is widely used in experiments in quantum optics, metrology and quantum information science. We report on the investigation of isotope...
Kouznetsova, I., Chwieralski, C.E., Bälder, R., Hinz, M., Braun, A., Krug, N., ...
Asthma is a chronic inflammatory disease of the airways which is accompanied by goblet cell metaplasia and mucus hypersecretion. Trefoil factor family (TFF) peptides represent major secretory...
Tumes, D.J., Cormie, J., Calvert, M.G., Stewart, K., Nassenstein, C., Braun, A., ...
Although exposed to similar allergic and environmental stimuli, not all humans develop asthma. Similarly, mouse strains vary in the degree of pathophysiology seen following induction of experimental...
Rössing, K., Bruder, M., Braun, A., Verres, T., Novak, N., Ständer, S., ...
Neuroimmune crosstalk in asthma: Dual role of the neurotrophin receptor p75NTR (2007)
Nassenstein, C., Kammertoens, T., Veres, T.Z., Uckert, W., Spies, E., Fuchs, B., ...
BACKGROUND: Neurotrophins have been implicated in the pathogenesis of asthma because of their ability to induce airway inflammation and to promote hyperreactivity of sensory neurons, which reflects...
Schulte-Herbrüggen, O., Braun, A., Rochlitzer, S., Jockers-Scherübl, M.C., Hellweg, R.
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the protein family of neurotrophins. They both display profound neuromodulatory functions and are essentially involved...
Veres, T.Z., Rochlitzer, S., Shevchenkom, M., Fuchs, B., Prenzler, F., Nassenstein, C., ...
Neuroimmune interactions play a critical role in the pathogenesis of asthma. Symptoms like wheezing and cough have been attributed to neural dysregulation, whereas sensitization and the induction of...
Precision cut lung slices as tool for assessment of allergens (2007)
Switalla, S., Sewald, K., Henjakovic, M., Veres, T., Krug, N., Braun, A.
Studies on precision cut lung slices (PCLS) are part of the European Union project SENS-IT-IV. Aim of this project is the development and establishment of in vitro techniques for assessment of...
Henjakovic, M., Sewald, K., Switalla, S., Veres, T., Mätz-Rensing, K., Krug, N., ...
Technique of PCLS provides the possibility to address cellular and functional response to allergen substances under ex vivo conditions. Objective of this work is the assessment of the respiratory...
Braun, A., Hansen, T., Hoymann, H.G., Muhle, H.
The lung is a preferential site of drug delivery for new pharmaceuticals and particular biopharmaceuticals. Standard models for efficacy testing and the standard toxicology battery often fail to...
Function of pulmonary PACl receptor in a murine model of allergic asthma (2007)
Plappert, L., Quarcoo, D., Fuchs, B., Pilzner, C., Fischer, A., ...
Invasive and noninvasive methods for studying pulmonary function in mice (2007)
Glaab, T., Taube, C., Braun, A., Mitzner, W.
The widespread use of genetically altered mouse models of experimental asthma has stimulated the development of lung function techniques in vivo to characterize the functional results of genetic...
Inhibition of airway inflammation and HIV entry by NNY-CCL14 treatment: Role of CCR1 and CCR5 (2007)
Gupta, S., Fuchs, B., Schulz-Maronde, S., Heitland, A., Escher, S.E., Münch, J., ...
RATIONALE: Modulation of leukocyte recruitment through intervention with chemokine receptors is an attractive therapeutic strategy. METHODS: Efficacy and potency of NNY-CCL14, its ability to...
Trpsl regulates proliferation and apoptosis of chondrocytes through Stat3 signaling (2007)
Suemoto, H., Muragaki, Y., Nishioka, K., Sato, M., Ooshima, A., Itoh, S., ...
Tumes, Damon John, Cormie, James, Calvert, Michael G., Stewart, Kalev Janson, Nassenstein, C., Braun, A., ...
© 2007 by Society for Leukocyte Biology
Tumes, Damon John, Cormie, James, Calvert, Michael G., Stewart, Kalev Janson, Nassenstein, C., Braun, A., ...
© 2007 by Society for Leukocyte Biology
Anxiety and comorbid measures associated with PLXNA2 (2007)
Wray, N. R., James, M. R., Mah, S. P., Nelson, M., Andrews, G., Sullivan, P. F., ...
CONTEXT: Reduction in adult neurogenesis has been proposed as a mechanism for onset of depression. Semaphorins and their coreceptors, plexins, have been implicated in nervous system development and...
Tumes, D, Nassenstein, C, Braun, A, Connolly, A, Dent, L
Allergic asthma is characterized by reversible airways obstruction, hyperreactivity and the presence of inflammatory cells such as eosinophils in the lung. CBA/Ca mice develop lower levels of airway...
Anxiety and comorbid measures associated with PLXNA2 (2007)
Wray, N. R., James, M. R., Mah, S. P., Nelson, M., Andrews, G., Sullivan, P. F., ...
CONTEXT: Reduction in adult neurogenesis has been proposed as a mechanism for onset of depression. Semaphorins and their coreceptors, plexins, have been implicated in nervous system development and...
Neuro-immune interaction in allergic asthma. Role of neurotrophins (2006)
Nassenstein, C., Kutschker, J., Tumes, D., Braun, A.
The nature of persistent airway hyperreactivity and chronic inflammation in asthma remains unclear. It has been suggested that bi-directional neuroSimmune interaction plays an important role in the...
Nerve growth factor: The central hub in the development of allergic asthma?: Review (2006)
Nassenstein, C., Schulte-Herbrüggen, O., Renz, H., Braun, A.
Neurotrophins like nerve growth factor (NGF), originally described as nerve growth factors in neuronal development, have been implicated in many physiological processes in the last years. They are...
Jesch, N.K., Kuebler, J.F., Nguyen, H., Nave, H., Bottlaender, M., Teichmann, B., ...
PURPOSE: Laparoscopy has been associated with lower inflammatory responses. However, it has been postulated that minilaparotomy, in contrast to full laparotomy, is equally minimally invasive....
Density of dendritic cells in the human tracheal mucosa is age dependent and site specific (2006)
Tschernig, T., Vries, V.C. De, Debertin, A.S., Braun, A., Walles, T., Traub, F., ...
BACKGROUND: The mucosal immune system undergoes extensive changes in early childhood in response to environmental stimuli. Dendritic cells (DC) play a major role in the development of the immune...
The contribution of neurotrophins to the pathogenesis of allergic asthma: Review (2006)
Rochlitzer, S., Nassenstein, C., Braun, A.
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, NT-3 (neurotrophin 3) and NT-4 are known for regulating neuron development, function and survival. Beyond this, neurotrophins...
Nassenstein, C., Mohring, U.H., Luttmann, W., Virchow, J.C., Braun, A.
Neurotrophins are involved in the pathogenesis of allergic asthma. In addition to their influence on afferent sensory nerves within the lung, it has been shown in the last years that these factors...
Animal models of asthma: Innovative methods of lung research and new pharmacological targets (2006)
Allergic diseases like bronchial asthma are increasing in societies with western lifestyle. In the last years substantial progress was made in the understanding of the underlying mechanisms and...
Vries, A. De, Engels, F., Henricks, P.A., Leusink-Muis, T., McGregor, G.P., Braun, A., ...
Background: The neurotrophin nerve growth factor (NGF) has been implicated as a mediator in allergic asthma. Direct evidence that inhibition of NGF-induced activation of neurotrophin receptors leads...
Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice (2006)
Erpenbeck, V.J., Ziegert, M., Cavalet-Blanco, D., Martin, C., Bälder, R., Glaab, T., ...
BACKGROUND: The surfactant protein SP-D has been reported to reduce bronchial hyper-responsiveness, blood eosinophilia, and T-helper type 2 cytokines in models of allergic asthma. However, little is...
Nassenstein, C., Dawbarn, D., Pollock, K., Allen, S.J., Erpenbeck, V.J., Spies, E., ...
Background Neurotrophins have been implicated in the pathogenesis of asthma because of their ability to promote hyperreactivity of sensory neurons and to induce airway inflammation. Hyperreactivity...
Detection of allergen-induced airway hyperresponsiveness in isolated mouse lungs (2006)
Witzenrath, M., Ahrens, B., Kube, S.M., Braun, A., Hoymann, H.G., Hocke, A.C., ...
Airway hyperresponsiveness (AHR) is a hallmark of bronchial asthma. Important features of this exaggerated response to bronchoconstrictive stimuli have mostly been investigated in vivo in intact...
The course of allergen-induced leukocyte infiltration in human and experimental asthma (2006)
Lommatzsch, M., Julius, P., Kuepper, M., Garn, H., Bratke, K., Irmscher, S., ...
BACKGROUND: Although the timing of allergen-induced bronchoconstriction is well defined, there is little information about the kinetics of allergen-induced leukocyte infiltration in asthma and its...
Erpenbeck, V.J., Hagenberg, A., Krentel, H., Discher, M., Braun, A., Hohlfeld, J.M., ...
BACKGROUND: GATA-3 (GATA binding protein 3) and the proto-oncogene c-maf are Th2-regulating transcription factors that control the expression of interleukin (IL)-4 and IL-5, while T-bet (T-box...
Comparison of non-invasive measures of cholinergic and allergic airway responsiveness in rats (2006)
Glaab, T., Hecker, H., Stephan, M., Baelde, R., Braun, A., Korolewitz, R., ...
AIM: Non-invasive analysis of tidal expiratory flow parameters such as Tme/TE (time needed to reach peak expiratory flow divided by total expiratory time) or midexpiratory tidal flow (EF50) has been...
CD137-mediated immunotherapy for allergic asthma (2006)
Polte, T., Foell, J., Werner, C., Hoymann, H.G., Braun, A., Burdach, S., ...
The prevalence of asthma continues to increase. Asthma is caused by a Th2 cell-driven immune response. Its optimal treatment remains a challenge, and a sufficient immunotherapeutic approach to...
NNY-CCL14 acts on diverse CC chemokine receptors and prevents airway hyperresponsiveness (2006)
Gupta, S., Forssmann, U., Schulz-Maronde, S., Fuchs, B., Braun, A., ...
Mah, S., Nelson, M. R., DeLisi, L. E., Reneland, R. H., Markward, N., James, M. R., ...
The discovery of genetic factors that contribute to schizophrenia susceptibility is a key challenge in understanding the etiology of this disease. Here, we report the identification of a novel...
Mah, S., Nelson, M. R., DeLisi, L. E., Reneland, R. H., Markward, N., James, M. R., ...
The discovery of genetic factors that contribute to schizophrenia susceptibility is a key challenge in understanding the etiology of this disease. Here, we report the identification of a novel...
Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases (2005)
Hoyal, CR, Kammerer, S, Roth, RB, Reneland, R, Marnellos, G, Kiechle, M, ...
Fraunhofer IPM greift das Thema Mikrofilm wieder auf, um die aus dem Kulturgüterschutz seit langem bekannten Vorteile des Mediums auch für die moderne Datensicherung zu nutzen.
Gennari, A., Ban, M., Braun, A., Casati, S., Corsini, E., Dastych, J., ...
This is the report of a workshop organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to...
Neurotrophins in murine viscera: A dynamic pattern from birth to adulthood (2005)
Lommatzsch, M., Quarcoo, D., Schulte-Herbrüggen, O., Weber, H., Virchow, J.C., Renz, H., ...
There is growing evidence that target-derived neurotrophins regulate the function of visceral neurons after birth. However, the postnatal profile of neurotrophin supply from internal organs is poorly...
Weigt, H., Nassenstein, C., Tscherning, T., Mühlradt, P.F., Krug, N., Braun, A.
Rationale: The incidence and prevalence of allergic asthma, caused by Th2-mediated inflammation in response to environmental antigens, is increasing. Epidemiologic data suggest that a lack of...
Glaab, T., Ziegert, M., Bälder, R., Korolewitz, R., Braun, A., Hohlfeld, J.M., ...
BACKGROUND: This study seeks to compare the ability of repeatable invasive and noninvasive lung function methods to assess allergen-specific and cholinergic airway responsiveness (AR) in intact,...
Schulte-Herbrüggen, O., Nassenstein, C., Lommatzsch, M., Quarcoo, D., Renz, H., Braun, A.
Activated macrophages have been shown to produce brain-derived neurotrophic factor (BDNF) in diseases such as multiple sclerosis (MS) or allergic bronchial asthma (BA). However, there is little data...
Bälder, R., Fuchs, B., Bautsch, W., Zwirner, J., Kohl, J., Hoymann, H.G., ...
Airway hyperresponsiveness and airway inflammation are hallmarks of allergic asthma, the etiology of which is crucially linked to the presence of Th2 cytokines. A role for the complement...
Neurotrophin effects on eosinophils in allergic inflammation (2005)
Nassenstein, C., Braun, A., Nockher, W.A., Renz, H.
Elevated neurotrophin concentrations have been shown in nasal and bronchoalveolar lavage fluids as well as in the sera of patients with allergic rhinitis and asthma. Concentration of nerve growth...
Ruckert, R., Brandt, K., Braun, A., Hoymann, H.G., Herz, U., Budagian, V., ...
IL-15 has been shown to accelerate and boost allergic sensitization in mice. Using a murine model of allergic sensitization to OVA, we present evidence that blocking endogenous IL-15 during the...
A role for brain-derived neurotrophic factor in B cell development (2005)
Schuhmann, B., Dietrich, A., Sel, S., Hahn, C., Klingenspor, M., Lommatzsch, M., ...
In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell...
Dinh, Q.T., Mingomataj, E., Quarcoo, D., Groneberg, D.A., Witt, C., Klapp, B.F., ...
BACKGROUND: Allergic airway inflammation has been shown to induce pro-inflammatory neuropeptides such as tachykinin peptides substance P (SP) and neurokinin A (NKA) together with related peptide like...
Consequences of loss of PINCH2 expression in mice (2005)
Stanchi, F., Bordoy, R., Kudlacek, O., Braun, A., Pfeifer, A., Moser, M., ...
Determination of 20th Century Sea Level Rise (solicited) (2004)
Schröter, J., Kuo, C. Y., Shum, C. K., Yi, Y., Braun, A., Wenzel, M.
Erpenbeck, V.J., Hagenberg, A., Dulkys, Y., Elsner, J., Balder, R., Krentel, H., ...
There is increasing evidence for a role of pulmonary surfactant in asthma and allergic inflammation. In murine asthma models, recent studies have demonstrated that surfactant components downregulate...
Liebmann, B., Müller, M., Braun, A., Brakhage, A.A.
Aspergillus fumigatus is an important pathogen of immunocompromised hosts, causing pneumonia and invasive disseminated disease with high mortality. To determine the importance of the cyclic AMP...
Neuroimmune dysbalance in bronchial asthma: Critical role of Pan-Neurotrophin receptor p75 (2004)
Kerzel, S., Päth, G., Nockher, W.A., Quarcoo, D., Raap, U., Gronenberg, D.A., ...
Glaab, T., Mitzner, W., Braun, A., Ernst, H., Korolewitz, R., Hohlfeld, J.M., ...
Precise and repeatable measurements of pulmonary function in intact mice are becoming increasingly important for experimental investigations on various respiratory disorders including asthma. Here,...
Forssmann, U., Hartung, I., Bälder, R., Fuchs, B., Escher, S.E., Spodsberg, N., ...
CCR3 is responsible for tissue infiltration of eosinophils, basophils, mast cells, and Th2 cells, particularly in allergic diseases. In this context, CCR3 has emerged as a target for the treatment of...
Quarcoo, D., Schulte-Herbrüggen, O., Lommatzsch, M., Schierhorn, K., Hoyle, G.W., Renz, H., ...
Background Nerve growth factor (NGF) exerts an important functional impact on the pathogenesis of allergic diseases. Data obtained in animal models of allergic bronchial asthma indicate that NGF...
Weigt, H., Muhlradt, P.F., Larbig, M., Krug, N., Braun, A.
Dendritic cells (DC) are the most potent APCs with the capacity to induce, modulate, or shut down immune function. These features make them potentially useful for treating diseases associated with...
Braun, A., Ernst, H., Hoymann, H.G., Rittinghausen, S.
The laboratory mouse has developed into the preferred model system for biomedical research. Many investigators have turned to murine models of lung disease for several reasons. First, dense genetic...
Neurotrophins and neurotrophin receptors in allergic asthma (2004)
Nassenstein, C., Kerzel, S., Braun, A.
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4 play a pivotal role in the development of the nervous system. Despite their well-known effects...
Liebmann, B., Mühleisen, T., Müller, M., Hecht, M., Weidner, G., Braun, A., ...
Aspergillus fumigatus is an important pathogen of the immunocompromised host, causing pneumonia and invasive disseminated disease with high mortality. In order to determine the importance of lysine...
Braun, A., Lommatzsch, M., Neuhaus-Steinmetz, U., Quarcoo, D., Glaab, T., MacGregor, G.P., ...
Brain-derived neurotrophic factor (BDNF) is a candidate molecule for mediating functional neuronal changes in allergic bronchial asthma. Recently, enhanced production of BDNF during allergic airway...
Peters, E.M.J., Handjiski, B., Kuhlmei, A., Hagen, E., Bielas, H., Braun, A., ...
Recently, we have revealed the existence of a "brain-hair follicle axis" in murine skin and have identified the neuropeptide substance P (SP) as a key mediator of stress-induced hair growth...
Synthesis of SystemC Design: A Case Study of Digital Neural Networks (2004)
Lettnin, D., Braun, A., Bogdan, M., Gerlach, J., Rosenstiel, W.
Schlabach, S., Szabo, V., Vollath, D., Braun, A., Clasen, R.
European Materials Research Society Fall Meeting, Warszawa, PL, September 15-19, 2003
Braun, A., Wolff, M., Clasen, R., Schlabath, S., Xu, B., Vollath, D.
27th Annual Cocoa Beach Conf.and Exhibition on Advanced Ceramics and Compositions, Cocoa Beach, Fla., January 26-31, 2003
PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions (2003)
Braun, A., Bordoy, R., Stanchi, F., Moser, M., Kostka, G., Ehler, E., ...
PINCH is a five LIM domain protein involved in the regulation of integrin-mediated cell adhesion. It has been shown that PINCH interacts with integrin-linked kinase and Nck2. Here we describe a new...
Sakai, T., Li, S. H., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., ...
Integrin-mediated cell-matrix interactions are essential for development, tissue homeostasis, and repair. Upon ligand binding, integrins are recruited into focal adhesions (FAs). Integrin-linked...
Nguyen, M.T., Lue, H., Kleemann, R., Thiele, M., Tolle, G., Finkelmeier, D., ...
The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on...
Neuroimmune control of the pulmonary immune response (2003)
Allergic bronchial asthma (BA) is characterized by chronic inflammation of the airways, development of airway hyper-reactivity (AHR) and recurrent reversible airway obstruction. Target and effector...
Nassenstein, C., Braun, A., Erpenbeck, V.J., Lommatzsch, M., Schmidt, S., Krug, N., ...
Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations in allergic diseases. Neurotrophin...
Effect of anti-nerve growth factor on early and late airway responses in allergic rats (2003)
Glaab, T., Hecht, M., Korolewitz, R., Tschernig, T., Hohlfeld, J.M., ...
Background: The increased production of nerve growth factor (NGF) has been associated with allergen-induced airway hyperresponsiveness and enhanced airway inflammation in experimental models of...
Neurotrophins in allergic airway dysfunction: What the mouse model is teaching us (2003)
Lommatzsch, M., Braun, A., Renz, H.
Neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are potent mediators of neuronal plasticity in the adult. There is increasing evidence that they regulate...
Erpenbeck, V.J., Hohlfeld, J.M., Volkmann, B., Hagenberg, A., Geldmacher, H., Braun, A., ...
BACKGROUND: IL-9 is a T(H)2 cell-derived cytokine that might be involved in the pathophysiology of allergic diseases. Little is known about its expression and release during the allergic response in...
Weigt, H., Mühlradt, P.F., Emmendörffer, A., Krug, N., Braun, A.
Dendritic cells (DC) modulate immune responses depending on the nature of the antigens. Receptors capable of discriminating these antigens on the basis of the pathogen-associated molecular patterns...
Kerzel, S., Päth, G., Nockher, W.A., Quarcoo, D., Raap, U., Groneberg, D.A., ...
Bronchial asthma represents a severe chronic inflammatory disease with increasing prevalence. The pathogenesis is characterized by complex neuroimmune dysregulation. Although the immunopathogenesis...
Neuroimmune interactions in the pathogenesis of allergic asthma (2003)
Braun, A., Nockher, W.A., Renz, H.
Allergic asthma is characterized by chronic airway inflammation that has been implied to have an important role in the development of airway hyperresponsiveness (AHR) and recurrent reversible airway...
This document is the revised final report of the JRC-IPTS/ESTO project “Healthcare
Braun, A., Aszodi, A., Hellebrand, H., Berna, A., Fässler, R., Brandau, O.
Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFNI),...
Samulowitz, U., Kuhn, A., Brachtendorf, G., Nawroth, R., Braun, A., Bankfalvi, A., ...
Endomucin is a typical sialomucin that we recently identified on the surface of mouse endothelial cells and on putative hematopoetic clusters of the dorsal aorta in the embryo. We have generated a...
Beschichtung sammelt Schadstoffe (2002)
Ein neues Infrarotspektrometer misst Schadstoffe im Abwasser von Deponie und Industrie - vor Ort, schnell und mit einer Empfindlichkeit im unteren ppm-Bereich.
Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats (2002)
Glaab, T., Hoymann, H.G., Hohlfeld, J.M., Korolewitz, R., Hecht, M., Alarie, Y., ...
This study was designed to evaluate the value and applicability of tidal breathing pattern analysis to assess bronchoconstriction in conscious rats. Using noninvasive, head-out body plethysmography...
Control of nerve growth and plasticity (2002)
Braun, A., Nockher, W.A., Renz, H.
Respiratory function is under close control of the autonomic nervous system. Recent data indicate that dysfunction and dysregulation of both the non-adrenergic non-cholinergic (NANC) and cholinergic...
Augmentation of allergic early-phase reaction by nerve growth factor (2002)
Päth, G., Braun, A., Meents, N., Kerzel, S., Quarcoo, D., Raap, U., ...
The allergic early-phase reaction, a hallmark of allergic bronchial asthma, is caused by allergen and immunoglobulin E-dependent mediator release from mast cells. It was previously shown that nerve...
Quarcoo, D., Päth, G., Lommatzsch, M., Renz, H., Braun, A.
There is growing evidence that besides the classical Th2 cytokines IL-4, IL-5 and IL-13, the nerve growth factor (NGF), a member of the neurotrophin family, plays a central role in the development of...
Die mögliche Bedeutung der Neurotrophine in der Pathogenese des allergischen Asthmas (2001)
Nassenstein, C., Mayer, S., Braun, A., Lommatzsch, M., Renz, H., Luttmann, W., ...
Bronchial asthma has been defined as a chronic disorder associated with bronchial hyperresponsiveness. Although the number of immune cells which in-bronchial hyperresponsiveness (BHR), the precise...
Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice (2001)
Glaab, T., Daser, A., Braun, A., Neuhaus-Steinmetz, U., Fabel, H., Alarie, Y., ...
A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c mice. With head-out body plethysmography and the decrease in tidal midexpiratory flow (EF(50)) as an...
Nerve growth factor induces airway hyperresponsiveness in mice (2001)
Braun, A., Quarcoo, D., Schulte-Herbrüggen, O., Lommatzsch, M., Hoyle, G., Renz, H.
BACKGROUND: Previous studies indicated an upregulation of nerve growth factor (NGF) production during allergic inflammation. However, the function of NGF in the lungs is currently poorly understood....
Stress and atopic eczema (2001)
Kupfer, J., Gieler, U., Braun, A., Niemeier, V., Huzler, C., Renz, H.
Braun, A., Lommatzsch, M., Lewin, G.R., Virchow, J.C., Renz, H.
BACKGROUND: Bronchial asthma (BA) is characterized by a unique type of airway inflammation, epithelial cell damage and increased airway smooth muscle (ASM) contractility. The regulatory network...
Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., ...
Neurotrophins exert many biological effects not directly targeted at neurons, including modulation of keratinocyte proliferation and apoptosis in vitro. Here we exploit the cyclic growth and...
Braun, A., Lommatzsch, M., Mannsfeld, A., Neuhaus-Steinmetz, U., Fischer, A., Schnoy, N., ...
The aim of this study was to investigate production and cellular sources of brain-derived neurotrophic factor (BDNF) production in allergic asthma. For this purpose a mouse model of chronic and...
Lommatzsch, M., Braun, A., Mannsfeldt, A., Botchkarev, V.A., Botchkareva, N.V., Paus, R., ...
Brain-derived neurotrophic factor (BDNF) plays a crucial role for the survival of visceral sensory neurons during development. However, the physiological sources and the function of BDNF in the adult...
Herz, U., Gerhold, K., Gruber, C., Braun, A., Wahn, U., Renz, H., ...
BACKGROUND: Epidemiologic studies suggest an inverse correlation between infections and development of atopy. The purpose of this study was to test the hypothesis whether a preexisting Th1-type...
Botchkarev, V.A., Botchkareva, N.V., Lommatzsch, M., Peters, E.M., Lewin, G.R., Subramaniam, A., ...
Besides their recognized dependence on nerve growth factor (NGF) during development, the dependence of mature sympathetic ganglion neurons on other neurotrophins is still unclear. Here, we have...
Virchow, J.C., Julius, P., Lommatzsch, M., Luttmann, W., Renz, H., Braun, A.
The mechanisms linking inflammation and airway hyperresponsiveness in allergic bronchial asthma are still not completely defined. Since neurotrophic factors increase nerve excitability and...
Flammgeschuetzte Kompositwerkstoffe (1997)
Storch, W., Wolter, H., Braun, A.
Fireproof composite material contains: (a) a resin made from cpd(s). of formula (I); and (b) inorganic, flame-inhibiting hydroxide, sulphate and/or hydrate(s). XaRbSiR'(4-a-b) (I) X = a hydrolysable...
Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1 (1994)
Braun, A., Kammerer, S., Weissenhorn, Winfried, Weiß, Elisabeth, Cleve, H.
A gene (X33) localized on human chromosome 1 has been detected by crossreaction of its fusion protein with a monospecific antiserum directed against human vitamin-D-binding protein (hDBP;...
Haemorheological changes in uraemic children in response to erythropoietin treatment (1993)
Böhler, T., Leo, A., Linderkamp, O., Braun, A., Schärer, K.
The increased risk of hypertension during treatment of uraemic patients with recombinant human erythropoietin (rHuEpo) has been related to increased blood viscosity. We therefore studied Theological...
A novel sequence polymorphism in exon 1 of the human vitamin D-binding protein (GC) gene (1993)
Braun, A., Kofler, A., Bichlmaier, R., Kammerer, S., Cleve, H.
The trigger system of the OPAL experiment at LEP (1991)
Arignon, M, Ball, A H, Bell, K W, Bramhall, M, Braun, A, Carter, A A, ...
Herstellung und Eigenschaften von glasfaserverstaerkten Kunststoff-Stahl-Schichtwerkstoffen. (1982)
Fachtagung Verbundwerkstoffe, Konstanz, 17.-18.April 1980
Oxygen-Effect in #g-irradiated DNA. (1970)
Luecke-Huhle, C., Braun, A., Hagen, U.
Zeitschrift fuer Naturforschung, 25b(1970) S.1264-68
Sauerstoffeffekt an der Desoxyribonukleinsaeure im bestrahlten Nukleoprotein (1969)
Dissertation, Univ. Heidelberg 1969
Synthesis of kininogen and degradation of bradykinin by PC12 cells
Dendorfer, A, Wellhöner, P, Braun, A, Roscher, A A, Dominiak, P
In this study, the abilities of PC12 cells to synthesize and degrade kinins were investigated. Kinin formation was assessed as kinin and kininogen content of cells and supernatants in serum-free...
Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders.
Braun, A, Mouradian, M M, Mohr, E, Fabbrini, G, Chase, T N
The motor and cognitive effects of a selective D-1 dopamine receptor agonist, SKF 39393, were assessed in patients with Huntington's disease, Gilles de la Tourette's syndrome, tardive dyskinesia, and...
Fermilab Contributions to the FFTB
V. Bharadwaj, A. Braun, M. Halling, J. A. Holt, D. Still
The Final Focus Test Beam (FFTB) project at SLAC is a demonstration of the feasibility of making the extremely small spot sizes needed for future e + e - linear colliders. Fermilab joined the FFTB...
Schneider, J, Presek, P, Braun, A, Bauer, P, Konietzko, N, Wiesner, B, ...
Encoding, Rehearsal, and Recall in Signers and Speakers: Shared Network but Differential Engagement
Bavelier, D., Newman, A. J., Mukherjee, M., Hauser, P., Kemeny, S., Braun, A., ...
Short-term memory (STM), or the ability to hold verbal information in mind for a few seconds, is known to rely on the integrity of a frontoparietal network of areas. Here, we used functional magnetic...