Liu, Y, Liang, S, Tartakoff, A M
Heat shock causes major positive and negative changes in gene expression, drastically alters the appearance of the nucleolus and inhibits rRNA synthesis. We here show that it causes many yeast...
A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA. (1996)
Liang, S, Hitomi, M, Hu, Y H, Liu, Y, Tartakoff, A M
An enormous variety of primary and secondary mRNA structures are compatible with export from the nucleus to the cytoplasm. Therefore, there seems to be a mechanism for RNA export which is independent...
Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure. (1995)
Liang, S, Hitomi, M, Tartakoff, A M
The mechanisms of export of RNA from the nucleus are poorly understood; however, several viral proteins modulate nucleocytoplasmic transport of mRNA. Among these are the adenoviral proteins E1B-55kDa...
mRNA transport in yeast: time to reinvestigate the functions of the nucleolus. (1995)
Schneiter, R, Kadowaki, T, Tartakoff, A M
Nucleocytoplasmic transport of mRNA is vital to gene expression and may prove to be key to its regulation. Genetic approaches in Saccharomyces cerevisiae have led to the identification of conditional...
Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant. (1994)
Kadowaki, T, Hitomi, M, Chen, S, Tartakoff, A M
We have identified a set of genes that affect mRNA transport (mtr) from the nucleus to the cytoplasm of Saccharomyces cerevisiae. One of these genes, MTR2, has been cloned and shown to encode a novel...
Berger, M, Wetzler, E, August, J T, Tartakoff, A M
Upon activation of human neutrophils by chemoattractants, functionally important proteins are rapidly transported from intracellular granules and storage vesicles to the plasma membrane. This is...
Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors. (1994)
Singh, N, Zoeller, R A, Tykocinski, M L, Lazarow, P B, Tartakoff, A M
A single metabolic path leading to synthesis of ether lipids is known in animal cells, the major products of which are plasmalogens. To learn whether this peroxisomal path is also responsible for the...
Kadowaki, T, Goldfarb, D, Spitz, L M, Tartakoff, A M, Ohno, M
The RCC1 gene of mammals encodes a guanine nucleotide release protein (GNRP). RCC1 and a homolog in Saccharomyces cerevisiae (MTR1/PRP20/SRM1) have previously been implicated in control of mRNA...
A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm. (1992)
Kadowaki, T, Zhao, Y, Tartakoff, A M
Transport of mRNA from nucleus to cytoplasm is critical for eukaryotic gene expression; however, the mechanism of export is unknown. Selection and screening procedures have therefore been used to...
Singh, N, Singleton, D, Tartakoff, A M
Although many cells anchor surface proteins via moieties that are sensitive to phosphatidylinositol-specific phospholipase C (PI-PLC), the anchor moieties of surface proteins of mouse L929 cells...
Intracellular sites for storage and recycling of C3b receptors in human neutrophils. (1991)
Berger, M, Wetzler, E M, Welter, E, Turner, J R, Tartakoff, A M
Upon activation of human neutrophils, C3b receptors (type 1 complement receptors, CR1) are rapidly translocated from an intracellular pool to the surface, increasing plasma membrane expression 6- to...
The addition of glycophospholipid (GPL) anchors to certain membrane proteins occurs in the rough endoplasmic reticulum and is essential for transport of the proteins to the plasma membrane. Limited...
Atypical mannolipids characterize Thy-1-negative lymphoma mutants. (1991)
Lemansky, P, Gupta, D K, Meyale, S, Tucker, G, Tartakoff, A M
Essentially all eukaryotic cells, including murine lymphomas, express surface proteins, such as Thy-1, which are anchored by a phosphoinositol mannolipid. Putative mannolipid anchor precursors can be...
Turner, J R, Tartakoff, A M, Greenspan, N S
Recent studies have demonstrated the existence of single O-linked N-acetylglucosamine (O-GlcNAc) residues on cytoplasmic and nuclear glycoproteins. Labeled lectin and enzymatic techniques have been...
Inhibition of surface membrane maturation in schistosomula of Schistosoma mansoni. (1988)
Wiest, P M, Tartakoff, A M, Aikawa, M, Mahmoud, A A
The surface membrane of the multicellular parasite Schistosoma mansoni is radically reorganized during the transformation of cercariae into schistosomula. The current study investigates factors...
Wiest, P M, Tisdale, E J, Roberts, W L, Rosenberry, T L, Mahmoud, A A, Tartakoff, A M
Biosynthetic labelling experiments with cercariae and schistosomula of the multicellular parasitic trematode Schistosoma mansoni were performed to determine whether [3H]palmitate or [3H]ethanolamine...
Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure.
Liang, S, Hitomi, M, Tartakoff, A M
The mechanisms of export of RNA from the nucleus are poorly understood; however, several viral proteins modulate nucleocytoplasmic transport of mRNA. Among these are the adenoviral proteins E1B-55kDa...
A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm.
Kadowaki, T, Zhao, Y, Tartakoff, A M
Transport of mRNA from nucleus to cytoplasm is critical for eukaryotic gene expression; however, the mechanism of export is unknown. Selection and screening procedures have therefore been used to...
Intracellular sites for storage and recycling of C3b receptors in human neutrophils.
Berger, M, Wetzler, E M, Welter, E, Turner, J R, Tartakoff, A M
Upon activation of human neutrophils, C3b receptors (type 1 complement receptors, CR1) are rapidly translocated from an intracellular pool to the surface, increasing plasma membrane expression 6- to...
Turner, J R, Tartakoff, A M, Greenspan, N S
Recent studies have demonstrated the existence of single O-linked N-acetylglucosamine (O-GlcNAc) residues on cytoplasmic and nuclear glycoproteins. Labeled lectin and enzymatic techniques have been...
A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA.
Liang, S, Hitomi, M, Hu, Y H, Liu, Y, Tartakoff, A M
An enormous variety of primary and secondary mRNA structures are compatible with export from the nucleus to the cytoplasm. Therefore, there seems to be a mechanism for RNA export which is independent...
Schneiter, R, Hitomi, M, Ivessa, A S, Fasch, E V, Kohlwein, S D, Tartakoff, A M
The conditional mRNA transport mutant of Saccharomyces cerevisiae, acc1-7-1 (mtr7-1), displays a unique alteration of the nuclear envelope. Unlike nucleoporin mutants and other RNA transport mutants,...
Inhibition of surface membrane maturation in schistosomula of Schistosoma mansoni.
Wiest, P M, Tartakoff, A M, Aikawa, M, Mahmoud, A A
The surface membrane of the multicellular parasite Schistosoma mansoni is radically reorganized during the transformation of cercariae into schistosomula. The current study investigates factors...
Berger, M, Wetzler, E, August, J T, Tartakoff, A M
Upon activation of human neutrophils by chemoattractants, functionally important proteins are rapidly transported from intracellular granules and storage vesicles to the plasma membrane. This is...
Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant.
Kadowaki, T, Hitomi, M, Chen, S, Tartakoff, A M
We have identified a set of genes that affect mRNA transport (mtr) from the nucleus to the cytoplasm of Saccharomyces cerevisiae. One of these genes, MTR2, has been cloned and shown to encode a novel...
mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.
Schneiter, R, Kadowaki, T, Tartakoff, A M
Nucleocytoplasmic transport of mRNA is vital to gene expression and may prove to be key to its regulation. Genetic approaches in Saccharomyces cerevisiae have led to the identification of conditional...
Kadowaki, T, Schneiter, R, Hitomi, M, Tartakoff, A M
Synthesis of mRNA and rRNA occur in the chromatin-rich nucleoplasm and the nucleolus, respectively. Nevertheless, we here report that a Saccharomyces cerevisiae gene, MTR3, previously implicated in...
Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.
Singh, N, Zoeller, R A, Tykocinski, M L, Lazarow, P B, Tartakoff, A M
A single metabolic path leading to synthesis of ether lipids is known in animal cells, the major products of which are plasmalogens. To learn whether this peroxisomal path is also responsible for the...
The addition of glycophospholipid (GPL) anchors to certain membrane proteins occurs in the rough endoplasmic reticulum and is essential for transport of the proteins to the plasma membrane. Limited...
Singh, N, Singleton, D, Tartakoff, A M
Although many cells anchor surface proteins via moieties that are sensitive to phosphatidylinositol-specific phospholipase C (PI-PLC), the anchor moieties of surface proteins of mouse L929 cells...
Atypical mannolipids characterize Thy-1-negative lymphoma mutants.
Lemansky, P, Gupta, D K, Meyale, S, Tucker, G, Tartakoff, A M
Essentially all eukaryotic cells, including murine lymphomas, express surface proteins, such as Thy-1, which are anchored by a phosphoinositol mannolipid. Putative mannolipid anchor precursors can be...
Kadowaki, T, Goldfarb, D, Spitz, L M, Tartakoff, A M, Ohno, M
The RCC1 gene of mammals encodes a guanine nucleotide release protein (GNRP). RCC1 and a homolog in Saccharomyces cerevisiae (MTR1/PRP20/SRM1) have previously been implicated in control of mRNA...
Heat shock disassembles the nucleolus and inhibits nuclear protein import and poly(A)+ RNA export.
Liu, Y, Liang, S, Tartakoff, A M
Heat shock causes major positive and negative changes in gene expression, drastically alters the appearance of the nucleolus and inhibits rRNA synthesis. We here show that it causes many yeast...
Wiest, P M, Tisdale, E J, Roberts, W L, Rosenberry, T L, Mahmoud, A A, Tartakoff, A M
Biosynthetic labelling experiments with cercariae and schistosomula of the multicellular parasitic trematode Schistosoma mansoni were performed to determine whether [3H]palmitate or [3H]ethanolamine...
Temperature and energy dependence of secretory protein transport in the exocrine pancreas.
Pancreatic lobules pulse-labeled with [3H]leucine have been incubated at temperatures between 0 and 37 degrees C in the presence or absence of ongoing oxidative phosphorylation. Subcellular...
Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export.
Tseng, S S, Weaver, P L, Liu, Y, Hitomi, M, Tartakoff, A M, Chang, T H
The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated...
Rain, J C, Tartakoff, A M, Krämer, A, Legrain, P
The yeast Prp9p, Prp11p, Prp21p proteins form a multimolecular complex identified as the SF3a splicing factor in higher eukaryotes. This factor is required for the assembly of the prespliceosome....
Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure.
Liang, S, Hitomi, M, Tartakoff, A M
The mechanisms of export of RNA from the nucleus are poorly understood; however, several viral proteins modulate nucleocytoplasmic transport of mRNA. Among these are the adenoviral proteins E1B-55kDa...
A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm.
Kadowaki, T, Zhao, Y, Tartakoff, A M
Transport of mRNA from nucleus to cytoplasm is critical for eukaryotic gene expression; however, the mechanism of export is unknown. Selection and screening procedures have therefore been used to...
Intracellular sites for storage and recycling of C3b receptors in human neutrophils.
Berger, M, Wetzler, E M, Welter, E, Turner, J R, Tartakoff, A M
Upon activation of human neutrophils, C3b receptors (type 1 complement receptors, CR1) are rapidly translocated from an intracellular pool to the surface, increasing plasma membrane expression 6- to...
Turner, J R, Tartakoff, A M, Greenspan, N S
Recent studies have demonstrated the existence of single O-linked N-acetylglucosamine (O-GlcNAc) residues on cytoplasmic and nuclear glycoproteins. Labeled lectin and enzymatic techniques have been...
A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA.
Liang, S, Hitomi, M, Hu, Y H, Liu, Y, Tartakoff, A M
An enormous variety of primary and secondary mRNA structures are compatible with export from the nucleus to the cytoplasm. Therefore, there seems to be a mechanism for RNA export which is independent...
Schneiter, R, Hitomi, M, Ivessa, A S, Fasch, E V, Kohlwein, S D, Tartakoff, A M
The conditional mRNA transport mutant of Saccharomyces cerevisiae, acc1-7-1 (mtr7-1), displays a unique alteration of the nuclear envelope. Unlike nucleoporin mutants and other RNA transport mutants,...
Inhibition of surface membrane maturation in schistosomula of Schistosoma mansoni.
Wiest, P M, Tartakoff, A M, Aikawa, M, Mahmoud, A A
The surface membrane of the multicellular parasite Schistosoma mansoni is radically reorganized during the transformation of cercariae into schistosomula. The current study investigates factors...
Berger, M, Wetzler, E, August, J T, Tartakoff, A M
Upon activation of human neutrophils by chemoattractants, functionally important proteins are rapidly transported from intracellular granules and storage vesicles to the plasma membrane. This is...
Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant.
Kadowaki, T, Hitomi, M, Chen, S, Tartakoff, A M
We have identified a set of genes that affect mRNA transport (mtr) from the nucleus to the cytoplasm of Saccharomyces cerevisiae. One of these genes, MTR2, has been cloned and shown to encode a novel...
mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.
Schneiter, R, Kadowaki, T, Tartakoff, A M
Nucleocytoplasmic transport of mRNA is vital to gene expression and may prove to be key to its regulation. Genetic approaches in Saccharomyces cerevisiae have led to the identification of conditional...
Kadowaki, T, Schneiter, R, Hitomi, M, Tartakoff, A M
Synthesis of mRNA and rRNA occur in the chromatin-rich nucleoplasm and the nucleolus, respectively. Nevertheless, we here report that a Saccharomyces cerevisiae gene, MTR3, previously implicated in...
Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.
Singh, N, Zoeller, R A, Tykocinski, M L, Lazarow, P B, Tartakoff, A M
A single metabolic path leading to synthesis of ether lipids is known in animal cells, the major products of which are plasmalogens. To learn whether this peroxisomal path is also responsible for the...
The addition of glycophospholipid (GPL) anchors to certain membrane proteins occurs in the rough endoplasmic reticulum and is essential for transport of the proteins to the plasma membrane. Limited...
Singh, N, Singleton, D, Tartakoff, A M
Although many cells anchor surface proteins via moieties that are sensitive to phosphatidylinositol-specific phospholipase C (PI-PLC), the anchor moieties of surface proteins of mouse L929 cells...
Atypical mannolipids characterize Thy-1-negative lymphoma mutants.
Lemansky, P, Gupta, D K, Meyale, S, Tucker, G, Tartakoff, A M
Essentially all eukaryotic cells, including murine lymphomas, express surface proteins, such as Thy-1, which are anchored by a phosphoinositol mannolipid. Putative mannolipid anchor precursors can be...
Kadowaki, T, Goldfarb, D, Spitz, L M, Tartakoff, A M, Ohno, M
The RCC1 gene of mammals encodes a guanine nucleotide release protein (GNRP). RCC1 and a homolog in Saccharomyces cerevisiae (MTR1/PRP20/SRM1) have previously been implicated in control of mRNA...
Heat shock disassembles the nucleolus and inhibits nuclear protein import and poly(A)+ RNA export.
Liu, Y, Liang, S, Tartakoff, A M
Heat shock causes major positive and negative changes in gene expression, drastically alters the appearance of the nucleolus and inhibits rRNA synthesis. We here show that it causes many yeast...
Wiest, P M, Tisdale, E J, Roberts, W L, Rosenberry, T L, Mahmoud, A A, Tartakoff, A M
Biosynthetic labelling experiments with cercariae and schistosomula of the multicellular parasitic trematode Schistosoma mansoni were performed to determine whether [3H]palmitate or [3H]ethanolamine...
Temperature and energy dependence of secretory protein transport in the exocrine pancreas.
Pancreatic lobules pulse-labeled with [3H]leucine have been incubated at temperatures between 0 and 37 degrees C in the presence or absence of ongoing oxidative phosphorylation. Subcellular...
Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export.
Tseng, S S, Weaver, P L, Liu, Y, Hitomi, M, Tartakoff, A M, Chang, T H
The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated...
Rain, J C, Tartakoff, A M, Krämer, A, Legrain, P
The yeast Prp9p, Prp11p, Prp21p proteins form a multimolecular complex identified as the SF3a splicing factor in higher eukaryotes. This factor is required for the assembly of the prespliceosome....