White, BA, Fox, R, Laird, J, Seaton, A, MacConnachie, A
No abstract available.
Mackintosh, CL, MacConnachie, A, Nandwani, R, Seaton, A, Winter, A, Fox, R
No abstract available.
Managing HIV in pregnancy in Glasgow (2008)
Patton, V, Fox, R, Nandwani, R, Seaton, A, MacConnachie, A, Hepburn, M, ...
No abstract available.
Regular audit can lead to changes in practice and better outcomes for pregnant women with HIV (2008)
Patton, V, Fox, R, Nandwani, R, Seaton, A, MacConnachie, A, Hepburn, M, ...
No abstract available.
Experience of myocardial infarction in a Glasgow HIV cohort (2008)
English, S, Winter, A, Nandwani, R, MacConnachie, A, Seaton, A, Fox, R
No abstract available.
From nurture to Nature--the story of the Aberdeen asthma dietary hypothesis (2008)
This article recounts the story of the dietary hypothesis for the rise in asthma and allergies from the first idea to publication of papers showing an association of maternal diet during pregnancy...
Cl Tran, K Donaldson, V Stones, T Fern, A Ford, N Christofi, ...
A scoping study to identify hazard data
Organic solvent exposure, genes, and risk of neuropsychological impairment (2002)
Dick, F., Semple, S., Osborne, A., Soutar, A., Seaton, A., Cherrie, J.W., ...
Background: Subtle cognitive and neurological impairments have been found in some workers exposed to organic solvents. Whether these effects occur at or below current legal limits for occupational...
Exposure to Ultrafine Particles and PM2.5 in Different Micro-Environments (2002)
Dennekamp, M., Mehenni, O. H., Cherrie, J. W., Seaton, A.
Acute exposure to particles in urban air has been found to be associated with adverse health effects. It has been suggested that the particle number concentration of ultrafine particles (
Asthma admissions and thunderstorms: a study of pollen, fungal spores, rainfall, and ozone (2001)
Anderson, W., Prescott, G.J., Packham, S., Mullins, J., Brookes, M., Seaton, A.
Asthma admissions have been reported to increase during thunderstorms. In some cases, this has been attributed to rises in pollen or fungal spore counts occurring alone or in combination with...
Dick, F., Semple, S., Chen, R., Seaton, A.
Five individuals are described who had participated in a study of former dockyard painters. All had worked between 16 years and 45 years as industrial painters, much of the time inside ships. All...
Egg-sharing in assisted conception: ethical and practical considerations (1996)
Ahuja, K.K., Simons, E.G., Fiamanya, W., Dalton, M., Armar, N.A., Kirkpatrick, P., ...
The present acute shortage of eggs for donation cannot be overcome unless adequate guidelines are set to alleviate the anxieties regarding payments, in cash or kind, to donors. The current Human...
Audit of sickness absence and fitness-for-work referrals (1995)
Agius, R. M., Seaton, A., Lee, R. J.
Since referrals in relation to sickness absence and fitness to continue work constitute an important part of occupational physicians' workloads, a study was carried out to audit this activity....
An audit of occupational medicine consultation records (1994)
Agius, R. M., Lee, R. J., Symington, I. S., Riddle, H. F. V., Seaton, A.
There is a need to develop and test methods of audit of the consultation process in occupational medicine and to draw conclusions from the findings. An external audit was carried out on 313 randomly...
SEATON, A., SEATON, R.A., WIGHTMAN, A.J.A.
Five non-smoking patients were diagnosed as having allergic bronchopulmonary aspergillosis in 1978/9. All have been treated since then with inhaled corticosteroids, using short courses of...
Occupational physicians and their work: prospects for audit (1993)
Agius, R. M., Lee, R. J., Murdoch, R. M., Symington, I. S., Riddle, H. F. V., Seaton, A.
An anonymous postal questionnaire was sent to 200 occupational physicians in the UK to determine their activities, the nature of the organizations within which they work and their attitudes and...
Organic Solvents and the Nervous System: Time for a Reappraisal? (1992)
“Toxic neuropsychiatric disease has become rather rare in the developed countries, but it is probably true to say that it is attracting almost more attention—amongst research workers at...
Major Neurological Disease and Occupational Exposure to Organic Solvents (1992)
SEATON, A, JELLINEK, EH, KENNEDY, P
Five patients are described who presented with major organic brain disease affecting one or more of pyramidal and extrapyramidal tracts, cerebellum, and higher cortical functions. All had a history...
Accidents in the Workplace (1991)
HARKER, C., MATHESON, A. B., ROSS, J. A. S., SEATON, A.
A prospective survey of patients attending the central Accident and Emergency Department and Eye Casualty Department in Aberdeen was made to determine the contribution of accidents at work to the...
Ambient particle inhalation and the cardiovascular system: potential mechanisms.
Donaldson, K, Stone, V, Seaton, A, MacNee, W
Well-documented air pollution episodes throughout recent history have led to deaths among individuals with cardiovascular and respiratory disease. Although the components of air pollution that cause...
Increase in bronchopulmonary infection due to branhamella catarrhalis.
McLeod, D T, Ahmad, F, Capewell, S, Croughan, M J, Calder, M A, Seaton, A
In a six month prospective study during the winter Branhamella catarrhalis was isolated from the sputum of 63 patients with symptoms of bronchopulmonary infection: 49 isolates were in pure culture...
Bronchopulmonary infection due to Branhamella catarrhalis.
McLeod, D T, Ahmad, F, Power, J T, Calder, M A, Seaton, A
Over six months Branhamella catarrhalis was isolated in pure culture from the sputum of 81 patients with symptoms of acute respiratory tract infection. Of 38 patients who were infected in the...
Asthma in the elderly: an epidemiological survey.
Burr, M L, Charles, T J, Roy, K, Seaton, A
A random sample of one in eight people aged 70 and over living at home in a south Wales town was surveyed to establish the prevalence of asthma. Subjects attended a screening clinic, where spirometry...
Asthma deaths in Cardiff 1963-74: 90 deaths outside hospital.
Macdonald, J B, Seaton, A, Williams, D A
In a detailed study of factors associated with death from bronchial asthma outside hospital 90 patients were investigated. The fatal attack was typically short and was most likely to occur in...
Asthma deaths in Cardiff 1963-74: 53 deaths in hospital.
MacDonald, J B, MacDonald, E T, Seaton, A, Williams, D A
In a study of factors associated with death from bronchial asthma in hospital 53 patients were investigated. Typically the fatal attack persisted for several days before admission to hospital and...
Ambient particle inhalation and the cardiovascular system: potential mechanisms.
Donaldson, K, Stone, V, Seaton, A, MacNee, W
Well-documented air pollution episodes throughout recent history have led to deaths among individuals with cardiovascular and respiratory disease. Although the components of air pollution that cause...
Increase in bronchopulmonary infection due to branhamella catarrhalis.
McLeod, D T, Ahmad, F, Capewell, S, Croughan, M J, Calder, M A, Seaton, A
In a six month prospective study during the winter Branhamella catarrhalis was isolated from the sputum of 63 patients with symptoms of bronchopulmonary infection: 49 isolates were in pure culture...
Bronchopulmonary infection due to Branhamella catarrhalis.
McLeod, D T, Ahmad, F, Power, J T, Calder, M A, Seaton, A
Over six months Branhamella catarrhalis was isolated in pure culture from the sputum of 81 patients with symptoms of acute respiratory tract infection. Of 38 patients who were infected in the...
Asthma in the elderly: an epidemiological survey.
Burr, M L, Charles, T J, Roy, K, Seaton, A
A random sample of one in eight people aged 70 and over living at home in a south Wales town was surveyed to establish the prevalence of asthma. Subjects attended a screening clinic, where spirometry...
Asthma deaths in Cardiff 1963-74: 90 deaths outside hospital.
Macdonald, J B, Seaton, A, Williams, D A
In a detailed study of factors associated with death from bronchial asthma outside hospital 90 patients were investigated. The fatal attack was typically short and was most likely to occur in...
Asthma deaths in Cardiff 1963-74: 53 deaths in hospital.
MacDonald, J B, MacDonald, E T, Seaton, A, Williams, D A
In a study of factors associated with death from bronchial asthma in hospital 53 patients were investigated. Typically the fatal attack persisted for several days before admission to hospital and...
Seaton, A., Davies, Glyn, Gaziano, D., Hughes, R. Osborne
Tests in three patients with asthma occurring only on exertion showed that F.E.V.1 fell progressively on exercise, to reach a minimum after 10 minutes. All patients showed a striking metabolic...
Bronchodilator effects of dry salbutamol powder administered by rotahaler
Hartley, J. P. R., Nogrady, S. G., Gibby, O. M., Seaton, A.
1 The bronchodilator effects of inhaled dry salbutamol powder (50, 100, 200 and 400 μg) have been compared in ten asthmatic patients with those of aerosolized salbutamol (200 μg) delivered from a...
Bronchodilator effect of delta1-tetrahydrocannabinol.
Hartley, J P, Nogrady, S G, Seaton, A
1 delta1-trans-tetrahydrocannabinol, (delta1-THC) produces bronchodilatation in asthmatic patients. 2 Administered in 62 microliter metered volumes containing 50--200 microgram by inhalation from an...
Seaton, A, Ruckley, V A, Addison, J, Brown, W R
Four men who mined barytes in Scotland and who developed pneumoconiosis are described. Three developed progressive massive fibrosis, from which two died; and one developed a nodular simple...
Suppression of host defences by Aspergillus fumigatus.
Robertson, M D, Seaton, A, Milne, L J, Raeburn, J A
An important feature of the microbicidal action of phagocytic cells is their ability to produce reactive oxygen intermediates. In an attempt to identify the mechanisms by which the fungus Aspergillus...
Resistance of spores of Aspergillus fumigatus to ingestion by phagocytic cells.
Robertson, M D, Seaton, A, Milne, L J, Raeburn, J A
Phagocytic cells are believed to have an important role in the eradication of fungal spores from the lung. The ability of human and mouse cells to phagocytose the opportunistic fungus Aspergillus...
Mycobacterium malmoense infections in Scotland: an increasing problem.
France, A J, McLeod, D T, Calder, M A, Seaton, A
During 1982-4 20 cases of Mycobacterium malmoense infection were identified in Scotland (13 male, seven female; age 34-82, median 62 years). Features of the disease were obtained from case notes and...
Pneumonia due to Branhamella catarrhalis.
Capewell, S, McLeod, D T, Croughan, M J, Ahmad, F, Calder, M A, Seaton, A
In 12 of 451 patients diagnosed as having pneumonia in a single hospital over 18 months the causative organism appeared to be Branhamella catarrhalis.
Assessment of variability of exercise tolerance limited by breathlessness.
Peel, E T, Soutar, C A, Seaton, A
A sequence of questions was designed to quantify the within subject variation of exercise tolerance limited by breathlessness, to serve as a guide to variation in airflow limitation for...
Pulmonary calcification following smallpox handler's lung
Ross, P. J., Seaton, A., Foreman, H. M., Evans, W. H. Morris
Ross, P. J., Seaton, A., Foreman, H. M., and Morris Evans, W. H. (1974).Thorax, 29, 659-665. Pulmonary calcification following smallpox handler's lung. A follow-up study of six nurses who developed...
A trial of oral delta-1-(trans)-tetrahydrocannabinol in reversible airways obstruction.
Davies, B H, Radcliffe, S, Seaton, A, Graham, J D
Sixteen patients with proven reversible airways obstruction were admitted to a double-blind study to compare the bronchodilator effects of oral delta-1-(trans)-tetrahydrocannabinol (delta-1-THC) and...
Miller, G J, Davies, B H, Cole, T J, Seaton, A
The bronchial responses to treadmill running and ergometer cycling have been compared in 13 adults with asthma. The exercises were performed on separate days with an interval ranging from three days...
Forced expiratory time--its reliability as a lung function test.
Macdonald, J B, Cole, T J, Seaton, A
Three studies of factors affecting variability of forced expiratory time (FET) have been carried out. In the first, different observers or repeated measurements over a few minutes were shown to make...
Hypersensitivity pneumonitis after exposure to isocyanates.
Charles, J, Bernstein, A, Jones, B, Jones, D J, Edwards, J H, Seal, R M, ...
Four patients exposed to isocyanate vapour developed dyspnoea associated with restriction and reduced gas transfer as well as moderate airways obstruction on lung function testing. In one patient...
Bruce, C, Weatherstone, R, Seaton, A, Taylor, W H
Plasma, whole blood, and urinary histamine levels have been determined in 64 normal subjects, in 10 patients with severe asthma, and in 10 control patients with other illnesses. The mean whole blood...
Intravenous or inhaled salbutamol in severe acute asthma?
Ten patients with life-threatening attacks of asthma (status asthmatiucus') were treated with salbutamol inhaled by intermittent positive pressure breathing, and their response in terms of rise in...
Metabolic effects of intravenous salbutamol in the course of acute severe asthma.
Nogrady, S G, Hartley, J P, Seaton, A
Peak expiratory flow rate and plasma free fatty acids, potassium, insulin, and glucose were measured in 10 patients admitted with acute severe asthma before and at frequent intervals for one hour...
Pulmonary and systemic aneurysms in a case of widespread arteritis.
Hartley, J P, Dinnen, J S, Seaton, A
A patient in whom asthma preceded the development of multiple pulmonary and systemic artery aneurisms died after dissection of the aorta. At necropsy he was found to have widespread arteritis of...
Hypersensitivity pneumonitis in a technician using Pauli's reagent.
A technician working in a medical laboratory used a spray of sodium diazobenzenesulphate (Pauli's reagent) in chromatography. She developed a respiratory illness with both airways obstruction and...
Intrabronchial metastases from renal carcinoma with recurrent tumour expectoration.
Jariwalla, A G, Seaton, A, McCormack, R J, Gibbs, A, Campbell, I A, Davies, B H
Three patients are described who presented to their doctors with a history of coughing up pieces of tissue. These took the form of large bronchial casts and consisted of intrabronchial deposits of...
Pneumoconiosis of shale miners.
Seaton, A, Lamb, D, Brown, W R, Sclare, G, Middleton, W G
Four patients are described in whom pneumoconiosis was diagnosed towards the end of a lifetime's work in shale mines. All developed complicated pneumoconiosis, diagnosed in two cases at necropsy, in...
Oilseed rape and seasonal symptoms: epidemiological and environmental studies.
Soutar, A, Harker, C, Seaton, A, Brooke, M, Marr, I
BACKGROUND--There is widespread concern that the cultivation of oilseed rape leads to seasonal epidemics of respiratory symptoms in populations living in the neighbourhood, and it has been suggested...
Clinical and immunological reactions to Aspergillus niger among workers at a biotechnology plant.
Topping, M D, Scarisbrick, D A, Luczynska, C M, Clarke, E C, Seaton, A
The workforce at a biotechnology plant producing citric acid by fermentation of molasses with a strain of Aspergillus niger was studied. A combination of a respiratory questionnaire and clinical...
Exposure to oxides of nitrogen: respiratory symptoms and lung function in British coalminers.
Robertson, A, Dodgson, J, Collings, P, Seaton, A
Five hundred and sixty British coalminers with relatively high or relatively low exposures to oxides of nitrogen, based on measurements of concentrations of these gases at nine collieries over four...
Ruckley, V A, Fernie, J M, Chapman, J S, Collings, P, Davis, J M, Douglas, A N, ...
The pathology and dust content of lungs from 261 coalminers in relation to the appearances of their chest radiographs taken within four years of death were examined. Radiological opacities of...
Respiratory and allergic symptoms in wool textile workers.
Love, R G, Smith, T A, Gurr, D, Soutar, C A, Scarisbrick, D A, Seaton, A
An epidemiological study of 2153 workers in 15 West Yorkshire wool textile mills was conducted to determine relations between respiratory symptoms and exposure to inspirable wool mill dust. A...
Intramuscular triamcinolone acetonide in chronic severe asthma.
McLeod, D T, Capewell, S J, Law, J, MacLaren, W, Seaton, A
Seventeen subjects with chronic severe asthma completed a 48 week prospective, double blind study with crossover of treatment at 24 weeks, in which triamcinolone acetonide 80 mg intramuscularly every...
Slight, J, Nicholson, W J, Mitchell, C G, Pouilly, N, Beswick, P H, Seaton, A, ...
BACKGROUND: Aspergillus fumigatus is a fungus that grows on dead and decaying organic matter in the environment and whose spores are present ubiquitously in the air. The fungus causes a range of...
Clinical reactions to Aspergillus niger in a biotechnology plant: an eight year follow up.
The manufacture of citric acid by fermentation of molasses with Aspergillus niger has previously been described as a cause of occupational asthma in a factory. A longitudinal survey of the workforce...
Questionnaire for the identification of back pain for epidemiological purposes.
Agius, R M, Lloyd, M H, Campbell, S, Hutchison, P, Seaton, A, Soutar, C A
OBJECTIVES--To design a questionnaire for the identification and assessment of severity of back pain for epidemiological purposes, and gain preliminary experience of its use. METHODS--A group of...
Oilseed rape and bronchial reactivity.
Soutar, A, Harker, C, Seaton, A, Packe, G
OBJECTIVES--To investigate atopy and changes in symptoms, peak flow rate, and bronchial reactivity in people complaining of symptoms during the oilseed rape flowering season. METHODS--37 people who...
Watt, M, Godden, D, Cherrie, J, Seaton, A
OBJECTIVE--To investigate the differences between measurements of personal exposure to particulate air pollution and static area measurements in a group of people working close to traffic and to...
Episode of toxic gas exposure in sewer workers.
Watt, M M, Watt, S J, Seaton, A
OBJECTIVES: Sewer workers are used to unpleasant smells, but may be required to investigate unusual ones. Twenty six men were involved in investigation of episodes of such a smell after neighbourhood...
Occupational accidents presenting to the accident and emergency department.
Harker, C, Matheson, A B, Ross, J A, Seaton, A
A prospective survey of patients attending the major Accident and Emergency Department in Aberdeen was undertaken. This department serves a population of 500,000 and sees some 50% of all accidents in...
Impairment of colour vision in workers exposed to organic solvents
Semple, S, Dick, F, Osborne, A, Cherrie, J, Soutar, A, Seaton, A, ...
OBJECTIVES—To investigate loss of colour vision related to exposure to solvents and the role of three enzyme polymorphisms in modifying the risk in exposed workers. METHODS—A sample was studied...
Exposure to organic solvents and personality
Chen, R, Dick, F, Semple, S, Seaton, A, Walker, L
OBJECTIVES—Although cognitive and neuropsychological changes have been found after high cumulative exposures to solvents, it is not clear whether such exposures are associated with personality...
Stimulation of IL-8 release from epithelial cells by gas cooker PM10: a pilot study
Dick, C, Dennekamp, M, Howarth, S, Cherrie, J, Seaton, A, Donaldson, K, ...
OBJECTIVE—To measure the effect of matter collected by a method that has a 50% efficiency for particles with an aerodynamic diameter of 10 µm (PM10), generated by gas and electric cooking, on...
Acute respiratory effects of particles: mass or number?
Osunsanya, T, Prescott, G, Seaton, A
OBJECTIVES—To determine whether associations might be found, in patients with chronic airflow obstruction, between symptoms, peak flow rate (PEF), and particle mass and numbers, and to assess which...
Nasal, eye, and skin irritation in dockyard painters
Chen, R, Semple, S, Dick, F, Seaton, A
OBJECTIVES—To determine whether the risk of irritant symptoms in painters is related to their exposure to paint. METHODS—The prevalences of skin, eye and nasal symptoms were compared in...
Ultrafine particles and nitrogen oxides generated by gas and electric cooking
Dennekamp, M, Howarth, S, Dick, C, Cherrie, J, Donaldson, K, Seaton, A
OBJECTIVES—To measure the concentrations of particles less than 100 nm diameter and of oxides of nitrogen generated by cooking with gas and electricity, to comment on possible hazards to health in...
Hajat, S, Anderson, H, Atkinson, R, Haines, A, Seaton, A.
Objectives: Few published studies have examined the effect of air pollution on upper respiratory conditions. Furthermore, most epidemiological studies on air pollution focus on mortality or hospital...
Particulate air pollution and the blood
Seaton, A., Soutar, A., Crawford, V., Elton, R., McNerlan, S., Cherrie, J., ...
BACKGROUND—Particulate air pollution has been associated with excess deaths from, and increases in hospital admissions for, cardiovascular disease among older people. A study was undertaken to...
Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia
Hijazi, N., Abalkhail, B., Seaton, A.
BACKGROUND—The causes of the worldwide increases in asthma and allergic diseases in childhood, which seem to relate to increasing prosperity, are unknown. We have previously hypothesised that a...
Quartz exposures and severe silicosis: a role for the hilar nodes
BACKGROUND: Two stonemasons working together in an environment with high concentrations of quartz pursued very different clinical courses; one died of rapidly progressive silicosis and the other...
OBJECTIVES: To study the prevalences of neuropsychological symptoms in male and female dockyard painters in China and to compare them with those in British dockyard painters. METHODS: All 116...
Chen, R., Dick, F., Seaton, A.
OBJECTIVES: To study mortality and prevalence of neuropsychological symptoms among a cohort of painters known to have been heavily exposed to organic solvents. METHODS: A mortality study of 1292 male...
Is colour vision impairment associated with cognitive impairment in solvent exposed workers?
Dick, F, Semple, S, Soutar, A, Osborne, A, Cherrie, J, Seaton, A
Methods: A sample of 82 painters and 38 other subjects were studied. Alcohol, drug, and smoking histories were obtained. Colour vision was tested using the Lanthony D-15-d colour vision test....
Bronchial reactivity and dietary antioxidants
Soutar, A., Seaton, A., Brown, K.
BACKGROUND: It has been postulated that dietary antioxidants may influence the expression of allergic diseases and asthma. To test this hypothesis a case-control study was performed, nested in a...
Opitz oculo-genito-laryngeal syndrome: a rare cause of recurrent aspiration pneumonia in an adult
De Silva, D., Osborne, A., Simpson, S. A., Dean, J. C., Seaton, A.
Declining incidence of episodes of asthma
BERNSEN, R, VAN DER WOUDEN, J C, FLEMING, D, CROSS, K, SEATON, A, FLEMING, D, ...
The London Underground: dust and hazards to health
Seaton, A, Cherrie, J, Dennekamp, M, Donaldson, K, Hurley, J, Tran, C
Aims: To assess hazards associated with exposure to dust in the London Underground railway and to provide an informed opinion on the risks to workers and the travelling public of exposure to tunnel...