Adelfa E. Serrano

Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei (2009)

González-Pons, María, Szeto, Ada C, González-Méndez, Ricardo, Serrano, Adelfa E

Abstract Background The ATP-binding cassette (ABC) superfamily is one of the largest evolutionarily conserved families of proteins. ABC proteins play key roles in cellular detoxification of...

PLASMODIUM YOELII: IDENTIFICATION AND PARTIAL CHARACTERIZATION OF AN MDR1 GENE IN AN ARTEMISININ-RESISTANT LINE (2004)

Iván Ferrer-Rodríguez, José Pérez-Rosado, Gary W. Gervais, Wallace Peters, Brian L. Robinson, Adelfa E. Serrano

The molecular mechanisms by which the malarial parasite has managed to develop resistance to many antimalarial drugs remain to be completely elucidated. Mutations in the pfmdr1 gene of Plasmodium...

The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission

Vega-Rodríguez, Joel, Franke-Fayard, Blandine, Dinglasan, Rhoel R., Janse, Chris J., Pastrana-Mena, Rebecca, Waters, Andrew P., ...

Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species....