Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target (2009)
Albini, Adriana, Brigati, Claudio, Ventura, Agostina, Lorusso, Girieca, Pinter, Marta, Morini, Monica, ...
Abstract Background Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct...
Unsung Hero Robert C. Gallo (2009)
Abbadessa, Giovanni, Accolla, Roberto, Aiuti, Fernando, Albini, Adriana, Aldovini, Anna, Alfano, Massimo, ...
Awarding the Nobel prize in physiology or medicine to Francoise Barré-Sinoussi and Luc Montagnier for the discovery of HIV-1, the causative agent of AIDS, is timely given the harm that the virus...
Larghero, Patrizia, Venè, Roberta, Minghelli, Simona, Travaini, Giorgia, Morini, Monica, Ferrari, Nicoletta, ...
Lipoic acid (LA) is a sulfated antioxidant produced physiologically as a coenzyme of the pyruvate dehydrogenase complex; it is currently used for treatment of non-insulin-dependent diabetes to favor...
Dell'Eva, Raffaella, Ambrosini, Claudia, Minghelli, Simona, Noonan, Douglas M., Albini, Adriana, Ferrari, Nicoletta
Several natural compounds, especially plant products and dietary constituents, are able to exhibit ‘angiopreventive’ (anti-angiogenic chemoprevention) activities both in vitro and in vivo....
Albini, Adriana, Ferrari, N, Tosetti, F, Fassina, G, Benelli, R, Pfeffer, U, ...
No abstract available.
Regulation of angiogenesis by angiostatin through immune cells and IL 12 production (2006)
Noonan, Douglas M, Brigati, Claudio, Dell'Eva, Raffaela, Morini, Monica, Minghelli, Simona, Benelli, Roberto, ...
No abstract available.
Dell'Eva, Raffaella, Ambrosini, Claudia, Minghelli, Simona, Noonan, Douglas M., Albini, Adriana, Ferrari, Nicoletta
Several natural compounds, especially plant products and dietary constituents, are able to exhibit "angiopreventive" (anti-angiogenic chemoprevention) activities both in vitro and in vivo. Deguelin...
Kaposi's Sarcoma and HIV-Tat: Challenges to Antiangiogenesis Research (2005)
Albini, Adriana, Benelli, Roberto, Paleari, Laura, Pfeffer, Ulrich, Ferrari, Nicoletta, Noonan, Douglas
No abstract available.
Tumor Cell Invasion Inhibited by TIMP-2 (1991)
Albini, Adriana, Melchiori, Antonella, Santi, Leonardo, Liotta, Lance A., Brown, Peter D., Stetler-Stevenson, William G.
The 72-kd type IV collagenase is a member of the collagenase enzyme family that has been closely linked with the invasive phenotype of cancer cells. Previous studies have shown that both normal cells...
Albini, Adriana, Toffenetti, Judith, Zhu, Zhen, Chader, Gerald J., Noonan, Douglas M.
The interphotoreceptor retinoid-binding protein (IRBP) is limited in expression to retinal photoreceptor cells and a subset of pinealocytes. We have obtained a genomic clone containing the entire...
Marconcini, Lucia, Marchiò, Serena, Morbidelli, Lucia, Cartocci, Elena, Albini, Adriana, Ziche, Marina, ...
c-fos-induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D) is a secreted factor of the VEGF family that binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3. Here we...
HIV-1 Tat protein mimicry of chemokines
Albini, Adriana, Ferrini, Silvano, Benelli, Roberto, Sforzini, Sabrina, Giunciuglio, Daniela, Aluigi, Maria Grazia, ...
The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known...
Guenzi, Eric, Töpolt, Kristin, Lubeseder-Martellato, Clara, Jörg, Anita, Naschberger, Elisabeth, Benelli, Roberto, ...
Expression of the large GTPase guanylate binding protein-1 (GBP-1) is induced by inflammatory cytokines (ICs) in endothelial cells (ECs), and the helical domain of the molecule mediates the...
Marconcini, Lucia, Marchiò, Serena, Morbidelli, Lucia, Cartocci, Elena, Albini, Adriana, Ziche, Marina, ...
c-fos-induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D) is a secreted factor of the VEGF family that binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3. Here we...
HIV-1 Tat protein mimicry of chemokines
Albini, Adriana, Ferrini, Silvano, Benelli, Roberto, Sforzini, Sabrina, Giunciuglio, Daniela, Aluigi, Maria Grazia, ...
The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known...
Guenzi, Eric, Töpolt, Kristin, Lubeseder-Martellato, Clara, Jörg, Anita, Naschberger, Elisabeth, Benelli, Roberto, ...
Expression of the large GTPase guanylate binding protein-1 (GBP-1) is induced by inflammatory cytokines (ICs) in endothelial cells (ECs), and the helical domain of the molecule mediates the...
Regulation of angiogenesis by angiostatin through immune cells and IL 12 production
Noonan, Douglas M, Brigati, Claudio, Dell'Eva, Raffaela, Morini, Monica, Minghelli, Simona, Benelli, Roberto, ...
Albini, Adriana, Marchisone, Chiara, Del Grosso, Federica, Benelli, Roberto, Masiello, Luciana, Tacchetti, Carlo, ...
We developed an in vivo gene therapy approach to characterize and optimize the anti-angiogenic activity of class I interferons (IFNs), using packaging cell lines producing an amphotropic LXSN-based...
Biancone, Luigi, Cantaluppi, Vincenzo, Boccellino, Mariarosaria, Bussolati, Benedetta, Del Sorbo, Lorenzo, Conaldi, Pier Giulio, ...
In the present study, we evaluated whether motility of Kaposi’s sarcoma (KS) spindle cells induced by HIV-1 Tat protein is dependent on the synthesis of platelet-activating factor (PAF). The...
Endothelin Receptor Blockade Inhibits Proliferation of Kaposi’s Sarcoma Cells
Bagnato, Anna, Rosanò, Laura, Di Castro, Valeriana, Albini, Adriana, Salani, Debora, Varmi, Marco, ...
Endothelin-1 (ET-1) has been shown to be mitogenic for endothelial and several tumor cells through an autocrine mechanism. In this study we evaluated whether the tumorigenic KS IMM cell line deriving...
Rosanò, Laura, Spinella, Francesca, Di Castro, Valeriana, Nicotra, Maria Rita, Albini, Adriana, Natali, Pier Giorgio, ...
Endothelin-1 (ET-1) and its receptors are overexpressed in human Kaposi’s sarcoma lesions. Here we show that in human KS IMM cell line ET-1 increased secretion and activation of...
Miretti, Silvia, Roato, Ilaria, Taulli, Riccardo, Ponzetto, Carola, Cilli, Michele, Olivero, Martina, ...
Carlevaro, Mariella F., Albini, Adriana, Ribatti, Domenico, Gentili, Chiara, Benelli, Roberto, Cermelli, Silvia, ...
During endochondral bone formation, avascular cartilage differentiates to hypertrophic cartilage that then undergoes erosion and vascularization leading to bone deposition. Resting cartilage produces...
Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target
Albini, Adriana, Brigati, Claudio, Ventura, Agostina, Lorusso, Girieca, Pinter, Marta, Morini, Monica, ...
Prediction of breast cancer metastasis by genomic profiling: where do we stand?
Pfeffer, Ulrich, Romeo, Francesco, Noonan, Douglas M., Albini, Adriana
Current concepts conceive “breast cancer” as a complex disease that comprises several very different types of neoplasms. Nonetheless, breast cancer treatment has considerably improved through...
Margheri, Francesca, Serratì, Simona, Lapucci, Andrea, Anastasia, Chillà, Giusti, Betti, Pucci, Marco, ...
We have previously shown that endothelial cell matrix metalloprotease 12 (MMP12) and pentraxin 3 (PTX3) overproduction is the main alteration accounting for reduced proneness to angiogenesis in...