A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts
Aly, Ahmed S.I., Matuschewski, Kai
The Plasmodium life cycle is a sequence of alternating invasive and replicative stages within the vertebrate and invertebrate hosts. How malarial parasites exit their host cells after completion of...
Aly, Ahmed S I, Mikolajczak, Sebastian A, Rivera, Hilda Silva, Camargo, Nelly, Jacobs-Lorena, Vanessa, Labaied, Mehdi, ...
Malaria parasite sporozoites prepare for transmission to a mammalian host by upregulation of UIS (Upregulated in Infectious Sporozoites) genes. A number of UIS gene products are essential for the...
Mikolajczak, Sebastian A., Silva-Rivera, Hilda, Peng, Xinxia, Tarun, Alice S., Camargo, Nelly, Jacobs-Lorena, Vanessa, ...
The malaria parasite sporozoite transmission stage develops and differentiates within parasite oocysts on the Anopheles mosquito midgut. Successful inoculation of the parasite into a mammalian host...
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
Vaughan, Ashley M, O'Neill, Matthew T, Tarun, Alice S, Camargo, Nelly, Phuong, Thuan M, Aly, Ahmed S I, ...
Intracellular malaria parasites require lipids for growth and replication. They possess a prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid organelle...
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design
VanBuskirk, Kelley M., O'Neill, Matthew T., De La Vega, Patricia, Maier, Alexander G., Krzych, Urszula, Williams, Jack, ...
Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against subsequent malaria...