Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data (2007)
Neil Kumar, Alejandro Wolf-Yadlin, Forest M. White, Douglas A. Lauffenburger
Cellular behavior in response to stimulatory cues is governed by information encoded within a complex intracellular signaling network. An understanding of how phenotype is determined requires the...
MODELING HER2 EFFECTS ON CELL BEHAVIOR FROM MASS SPECTROMETRY PHOSPHOTYROSINE DATA (2006)
Neil Kumar, Alejandro Wolf-Yadlin, Forest Michael White, Douglas A Lauffenburger
Cellular behavior in response to stimulatory cues is governed by information encoded within a complex intracellular signaling network. An understanding of how phenotype is determined requires the...
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Wolf-Yadlin, Alejandro, Kumar, Neil, Zhang, Yi, Hautaniemi, Sampsa, Zaman, Muhammad, Kim, Hyung-Do, ...
Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in tumor progression for a variety of cancer types, how it dysregulates signaling networks governing cell...
Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data
Kumar, Neil, Wolf-Yadlin, Alejandro, White, Forest M, Lauffenburger, Douglas A
Cellular behavior in response to stimulatory cues is governed by information encoded within a complex intracellular signaling network. An understanding of how phenotype is determined requires the...
Wolf-Yadlin, Alejandro, Hautaniemi, Sampsa, Lauffenburger, Douglas A., White, Forest M.
Although recent developments in MS have enabled the identification and quantification of hundreds of phosphorylation sites from a given biological sample, phosphoproteome analysis by MS has been...
Linear combinations of docking affinities explain quantitative differences in RTK signaling
Gordus, Andrew, Krall, Jordan A, Beyer, Elsa M, Kaushansky, Alexis, Wolf-Yadlin, Alejandro, Sevecka, Mark, ...
Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing...
Maximum Entropy Reconstructions of Dynamic Signaling Networks from Quantitative Proteomics Data
Locasale, Jason W., Wolf-Yadlin, Alejandro
Advances in mass spectrometry among other technologies have allowed for quantitative, reproducible, proteome-wide measurements of levels of phosphorylation as signals propagate through complex...