Altin Gjymishka

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex (2008)

Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.

It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid...

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, Chin, Dudenhausen, Elizabeth, Chen, Hong, Pan, Yuan-Xiang, Gjymishka, Altin, Kilberg, Michael S.

For animals, dietary protein is critical for the nutrition of the organism and, at the cellular level, protein nutrition translates into amino acid availability. Amino acid deprivation triggers the...

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, Chin, Dudenhausen, Elizabeth, Chen, Hong, Pan, Yuan-Xiang, Gjymishka, Altin, Kilberg, Michael S.

For animals, dietary protein is critical for the nutrition of the organism and, at the cellular level, protein nutrition translates into amino acid availability. Amino acid deprivation triggers the...

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.

It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid...

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells*

Thiaville, Michelle M., Pan, Yuan-Xiang, Gjymishka, Altin, Zhong, Can, Kaufman, Randal J., Kilberg, Michael S.

The mammalian amino acid response (AAR) pathway is up-regulated by protein or amino acid depletion. This pathway involves detection of uncharged tRNA by the GCN2 kinase, phosphorylation of the...

Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells*

Gjymishka, Altin, Palii, Stela S., Shan, Jixiu, Kilberg, Michael S.

The activated amino acid response (AAR) and unfolded protein response (UPR) stress signaling pathways converge at the phosphorylation of translation initiation factor eIF2α. This eIF2α modification...