Probing Pathways of Innate Immunity Through the Study of Familial Mediterranean Fever.
Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by self-limiting attacks of fever, pain, and neutrophil influx in the joints, abdomen, chest or skin. FMF is caused by...
Pyrin Modulates the Intracellular Distribution of PSTPIP1
Waite, Andrea L., Schaner, Philip, Richards, Neil, Balci-Peynircioglu, Banu, Masters, Seth L., Brydges, Susannah D., ...
PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum,...