Scientific Commons: Andreas Offenhäusser

A 64-channel amplifier system for the recording of extracellular signals with planar metal microelectrodes is presented. Gold metal microelectrodes on glass wafers were fabricated using standard...

Micropatterned substrates for the growth of functional neuronal networks of defined geometry (2003)

Vogt,A. K., Lauer,L., Knoll,Wolfgang, Offenhäusser,Andreas

The in vitro assembly of neuronal networks with control over cell position and connectivity is a fascinating approach not only for topics in basic neuroscience research but also in diverse...

Backside contacted field effect transistor array for extracellular signal recording (2003)

Ingebrandt,S., Yeung,C. K., Staab,W., Zetterer,T., Offenhäusser,Andreas

A new approach to the design of field-effect transistor (FET) sensors and the use of these FETs in detecting extracellular electrophysiological recordings is reported. Backside contacts were...

Polysaccharide-supported planar bilayer lipid model membranes (2003)

Baumgart,T., Offenhäusser,Andreas

Bilayer lipid membranes were deposited onto two different thin water swellable polymer cushions predominantly by Langmuir- Blodgett trough methods. Membranes consisting of zwitterionic lipids...

Fusion of small unilamellar vesicles onto laterally mixed self- assembled monolayers of thiolipopeptides (2003)

Baumgart,T., Kreiter,Max, Lauer,H., Naumann,Renate, Jung,G., Jonczyk,A., ...

Monolayers of the thiolipopeptide NH2-Cys-Ala-Ser-Ala-Ala-Ser- Ser-Ala-Pro-Ser-Ser-(Myr)Lys(Myr)-OH (III) were formed on gold surfaces by self-assembly, mixed with a lateral spacer of the same...

Polysaccharide-supported planar bilayer lipid model membranes (2003)

Baumgart, T., Offenhäusser, Andreas

Bilayer lipid membranes were deposited onto two different thin water swellable polymer cushions predominantly by Langmuir- Blodgett trough methods. Membranes consisting of zwitterionic lipids...

Fusion of small unilamellar vesicles onto laterally mixed self- assembled monolayers of thiolipopeptides (2003)

Baumgart, T., Kreiter, Maximilian, Lauer, H., Naumann, Renate, Jung, G., Jonczyk, A., ...

Monolayers of the thiolipopeptide NH2-Cys-Ala-Ser-Ala-Ala-Ser- Ser-Ala-Pro-Ser-Ser-(Myr)Lys(Myr)-OH (III) were formed on gold surfaces by self-assembly, mixed with a lateral spacer of the same...

Backside contacted field effect transistor array for extracellular signal recording (2003)

Ingebrandt, S., Yeung, C. K., Staab, W., Zetterer, T., Offenhäusser, Andreas

A new approach to the design of field-effect transistor (FET) sensors and the use of these FETs in detecting extracellular electrophysiological recordings is reported. Backside contacts were...

64-Channel extended gate electrode arrays for extracellular signal recording (2003)

Ecken, H., Ingebrandt, S., Krause, M., Richter, D., Hara, M., Offenhäusser, Andreas

A 64-channel amplifier system for the recording of extracellular signals with planar metal microelectrodes is presented. Gold metal microelectrodes on glass wafers were fabricated using standard...

Micropatterned substrates for the growth of functional neuronal networks of defined geometry (2003)

Vogt, A. K., Lauer, L., Knoll, Wolfgang, Offenhäusser, Andreas

The in vitro assembly of neuronal networks with control over cell position and connectivity is a fascinating approach not only for topics in basic neuroscience research but also in diverse...

Lateral diffusion in substrate-supported lipid monolayers as a function of ambient relative humidity (2002)

Baumgart,T., Offenhäusser,Andreas

We analyzed the influence of water activity on the lateral self-diffusion of supported phospholipid monolayers. Lipid monolayer membranes were supported by polysaccharide cushions (chitosan and...

Electrophysiological recordings of patterned rat brain stem slice neurons (2002)

Lauer,L., Vogt,A., Yeung,C. K., Knoll,Wolfgang, Offenhäusser,Andreas

Dissociated neuronal Cultures on substrates patterned with extracellular matrix (ECM) proteins have yielded much information in the past. However, although the culture of brain slices has many...

Spreading of lipid monolayers on hydrophilic substrates at increased relative humidities (2002)

Baumgart,T., Offenhäusser,Andreas

A self-repairing ability of phospholipid monolayers deposited onto thin hydrogel films was observed by fluorescence microscopy, in terms of the expansion and lateral spreading of the monolayer into...

Photopolymerization of diacetylene lipid bilayers and its application to the construction of micropatterned biomimetic membranes (2002)

Morigaki,K., Baumgart,T., Jonas,Ulrich, Offenhäusser,Andreas, Knoll,Wolfgang

Photopolymerization of diacetylene-containing amphiphiles in substrate-supported bilayers has been studied in connection with the development of a new fabrication strategy of micropatterned...

Lipid vesicle fusion on mu CP patterned self-assembled monolayers: Effect of pattern geometry on bilayer formation (2002)

Jenkins,A. T. A., Bushby,R. J., Evans,S. D., Knoll,Wolfgang, Offenhäusser,Andreas, Ogier,S. D.

Microcontact printing (muCP) of lipophilic self-assembled monolayers (SAMs) has been used to fabricate micron dimensioned patterned surfaces that can be used as a means of attaching lipid bilayers to...

Proton transport through a peptide-tethered bilayer lipid membrane by the H+-ATP synthase from chloroplasts measured by impedance spectroscopy (2002)

Naumann,Renate, Baumgart,T., Graber,P., Jonczyk,A., Offenhäusser,Andreas, Knoll,Wolfgang

A lipid membrane was tethered to a gold film by a peptide spacer molecule terminated by a sulfhydryl group. Membranes were formed by fusion of liposomes prepared from egg phosphatidylcholine on self...

PDMS device for patterned application of microfluids to neuronal cells arranged by microcontact printing (2002)

Thiebaud,P., Lauer,L., Knoll,Wolfgang, Offenhäusser,Andreas

A microfluidic device in polydimethylsiloxane (PDMS) consisting of an eight lines micro-injection array integrated in a base flow channel has been realized. The device is assembled from multiple PDMS...

Proton transport through a peptide-tethered bilayer lipid membrane by the H+-ATP synthase from chloroplasts measured by impedance spectroscopy (2002)

Naumann, Renate, Baumgart, T., Graber, P., Jonczyk, A., Offenhäusser, Andreas, Knoll, Wolfgang

A lipid membrane was tethered to a gold film by a peptide spacer molecule terminated by a sulfhydryl group. Membranes were formed by fusion of liposomes prepared from egg phosphatidylcholine on self...

Lateral diffusion in substrate-supported lipid monolayers as a function of ambient relative humidity (2002)

Baumgart, T., Offenhäusser, Andreas

We analyzed the influence of water activity on the lateral self-diffusion of supported phospholipid monolayers. Lipid monolayer membranes were supported by polysaccharide cushions (chitosan and...

Dynamics of phospholipid monolayer membranes as a function of the membrane hydration state (2002)

Baumgart, T., Offenhäusser, Andreas

Photopolymerization of diacetylene lipid bilayers and its application to the construction of micropatterned biomimetic membranes (2002)

Morigaki, K., Baumgart, T., Jonas, Ulrich, Offenhäusser, Andreas, Knoll, Wolfgang

Photopolymerization of diacetylene-containing amphiphiles in substrate-supported bilayers has been studied in connection with the development of a new fabrication strategy of micropatterned...

Lipid vesicle fusion on mu CP patterned self-assembled monolayers: Effect of pattern geometry on bilayer formation (2002)

Jenkins, A. T. A., Bushby, R. J., Evans, S. D., Knoll, Wolfgang, Offenhäusser, Andreas, Ogier, S. D.

Microcontact printing (muCP) of lipophilic self-assembled monolayers (SAMs) has been used to fabricate micron dimensioned patterned surfaces that can be used as a means of attaching lipid bilayers to...

PDMS device for patterned application of microfluids to neuronal cells arranged by microcontact printing (2002)

Thiebaud, P., Lauer, L., Knoll, Wolfgang, Offenhäusser, Andreas

A microfluidic device in polydimethylsiloxane (PDMS) consisting of an eight lines micro-injection array integrated in a base flow channel has been realized. The device is assembled from multiple PDMS...

Spreading of lipid monolayers on hydrophilic substrates at increased relative humidities (2002)

Baumgart, T., Offenhäusser, Andreas

A self-repairing ability of phospholipid monolayers deposited onto thin hydrogel films was observed by fluorescence microscopy, in terms of the expansion and lateral spreading of the monolayer into...

Electrophysiological recordings of patterned rat brain stem slice neurons (2002)

Lauer, L., Vogt, A., Yeung, C. K., Knoll, Wolfgang, Offenhäusser, Andreas

Dissociated neuronal Cultures on substrates patterned with extracellular matrix (ECM) proteins have yielded much information in the past. However, although the culture of brain slices has many...

Validation of the use of field effect transistors for extracellular signal recording in pharmacological bioassays (2001)

Yeung,C. K., Ingebrandt,S., Krause,M., Offenhäusser,Andreas, Knoll,Wolfgang

The use of field effect transistors (FETs) in biomedical research has been in rapid progression in recent years. The present study aims to demonstrate a quantitative use of these devices in...

Modulation of the Growth and Guidance of the Rat Brain Stem Neurons Using Patterned Extracellular Matrix Proteins (vol 301, pg 147, 2001) (2001)

Yeung,C. K., Lauer,L., Offenhäusser,Andreas, Knoll,Wolfgang

Modulation of the Growth and Guidance of Rat Brain Stem Neurons Using Patterned Extracellular Matrix Proteins (2001)

Yeung,C. K., Lauer,L., Offenhäusser,Andreas, Knoll,Wolfgang

Model Network Architectures in vitro on Extracellular Recording Systems Using Microcontact Printing (2001)

Sprössler,C., Scholl,M., Denyer,M. C., Krause,M., Nakajima,K., Maelicke,A., ...

Cell-Transistor Hybrid Systems and their Potential Applications (2001)

Offenhäusser,Andreas, Knoll,Wolfgang

Patterning Solid-supported Lipid Bilayer Membranes by Lithographic Polymerization of a Diacetylene Lipid (2001)

Morigaki,K., Baumgart,T., Offenhäusser,Andreas, Knoll,Wolfgang

Validation of the use of field effect transistors for extracellular signal recording in pharmacological bioassays (2001)

Yeung, C. K., Ingebrandt, S., Krause, M., Offenhäusser, Andreas, Knoll, Wolfgang

The use of field effect transistors (FETs) in biomedical research has been in rapid progression in recent years. The present study aims to demonstrate a quantitative use of these devices in...

Modulation of the Growth and Guidance of the Rat Brain Stem Neurons Using Patterned Extracellular Matrix Proteins (vol 301, pg 147, 2001) (2001)

Yeung, C. K., Lauer, L., Offenhäusser, Andreas, Knoll, Wolfgang

Modulation of the Growth and Guidance of Rat Brain Stem Neurons Using Patterned Extracellular Matrix Proteins (2001)

Yeung, C. K., Lauer, L., Offenhäusser, Andreas, Knoll, Wolfgang

Model Network Architectures in vitro on Extracellular Recording Systems Using Microcontact Printing (2001)

Sprössler, C., Scholl, M., Denyer, M. C., Krause, M., Nakajima, K., Maelicke, A., ...

Cell-Transistor Hybrid Systems and their Potential Applications (2001)

Offenhäusser, Andreas, Knoll, Wolfgang

Patterning Solid-supported Lipid Bilayer Membranes by Lithographic Polymerization of a Diacetylene Lipid (2001)

Morigaki, K., Baumgart, T., Offenhäusser, Andreas, Knoll, Wolfgang

Spot Compliant Neuronal Networks by Structure Optimized Micro-contact Printing (2001)

Lauer, L., Klein, C., Offenhäusser, Andreas

Aligned Microcontact Printing of Biomolecules on Microelectronic Device Surfaces (2001)

Lauer, L., Ingebrandt, S., Scholl, M., Offenhäusser, Andreas

Surface Plasmon Microscopy Measurements of Lipid Vesicle Adsorption on a Micropatterned Self-Assembled Monolayer (2001)

Jenkins, A. T. A., Neumann, T., Offenhäusser, Andreas

Cardiomyocyte-Transistor-Hybrids for Sensor Application (2001)

Ingebrandt, S., Yeung, C. K., Krause, M., Offenhäusser, Andreas

Host-Guest Interactions at Self-Assembled Monolayers of Cyclodextrins on Gold (2000)

Beulen, M. W. J., Bügler, J., De Jong, M. R., Lammerink, B., Huskens, J., Schönherr, H., ...

Functional Tethered Lipid Bilayers (2000)

Knoll, Wolfgang, Frank, C. W., Heibel, C., Naumann, Renate, Offenhäusser, Andreas, Rühe, Jürgen, ...

Extended Gate Electrode Arrays for Extracellular Signal Recordings (2000)

Krause, M., Ingebrandt, S., Richter, D., Denyer, M., Scholl, M., Sprössler, C., ...

Ordered Networks of Rat Hippocampal Neurons Attached to Silicon Oxide Surfaces (2000)

Scholl, M., Sprössler, C., Denyer, M., Krause, M., Nakajima, K., Maelicke, A., ...

Bioassay Development: The Implications of Cardiac Myocyte Motility in vitro (1999)

Denyer, M. C. T., Riehle, M., Hayashi, J., Scholl, M., Sprössler, C., Britland, S. T., ...

Lateral Diffusion of Lipids in Silane-, Dextran- and S-layer-Supported Mono- and Bilayers (1999)

Györvary, E., Wetzer, B., Sleytr, U. B., Sinner, A., Offenhäusser, Andreas, Knoll, Wolfgang

Observation of the Dynamics of Live Cardiomyocytes through a Free-Running Scanning Near-Field Optical Microscopy Setup (1999)

Micheletto, R., Denyer, M., Scholl, M., Nakajima, K., Offenhäusser, Andreas, Hara, M., ...

The peptide-Tethered Lipid Membrane as a Biomimetic System to Incorporate Cytochrome C Oxidase in a Functionally Active Form (1999)

Naumann, Renate, Schmidt, E. K., Jonczyk, A., Fendler, K., Kadenbach, B., Liebermann, T., ...

Bio-elektronische Signal-Transduktion an Zell-Transistor-Hybridsystemen (1999)

Offenhäusser, Andreas, Knoll, Wolfgang

Tailoring of Surfaces with Ultrathin Polymer Films for Neuronal Survival and Growth in Culture (1999)

Rühe, Jürgen, Yano, R., Lee, J. S., Köberle, P., Knoll, Wolfgang, Offenhäusser, Andreas

Electrical Recordings from Rat Cardiac Muscle Cells Using Field-effect Transistors (1999)

Sprössler, C., Denyer, M., Britland, S., Knoll, Wolfgang, Offenhäusser, Andreas

Preliminary Study on the Suitability of a Pharmalogical Bio-assay based on Cardiac Myocytes Cultured over Microfabricated Microelectrode Arrays (1998)

Denyer, M. C. T., Riehle, M., Britland, S., Offenhäusser, Andreas

Pharmalogical Bioassay Development Using Rat Cardiac Myocytes Cultured over Microfabricated Extracellular Dedrode/FET Arrays (1998)

Denyer, M., Riehle, M., Sprössler, C., Britland, S., Offenhäusser, Andreas, Monaghan, W., ...

Preparation, Structural Characterization, and Functional Coupling of Tethered Membranes to Solid Supports (1998)

Knoll, Wolfgang, Bunjes, N., Denyer, M., Heibel, C., Matsuzawa, M., Naumann, Renate, ...

Incorporation of the Acetylcholine Receptor Dimer from Torpedo Californica in a Peptide Supported Lipid Membrane Investigated by Surface Plasmon and Fluorescence Spectroscopy (1998)

Schmidt, E. K., Liebermann, T., Kreiter, Maximilian, Jonczyk, A., Naumann, Renate, Offenhäusser, Andreas, ...

The Electrical Characterization of Supported Phosphorlipid Bilayers Using Titanium Titanium Oxide Microelectrodes (1998)

Sinner, A., Offenhäusser, Andreas

Long-term Recording System Based on Field-effect Transistor Arrays for Monitoring Electrogenic Cells in Culture (1998)

Sprössler, C., Richter, D., Denyer, M., Offenhäusser, Andreas

Fusion of small unilamellar lipid vesicles to alkanethiol and thiolipid self-assembled monolayers on gold (1997)

Lingler, S., Rubinstein, I., Knoll, Wolfgang, Offenhäusser, Andreas

Supramolecular interfacial architectures for controlled electron transfer (1997)

Knoll, Wolfgang, Pirwitz, G., Tamada, K., Offenhäusser, Andreas, Hara, M.

Electrophysiological development of embryonic hippocampal neurons from the rat grown on synthetic thin films (1997)

Offenhäusser, Andreas, Spöossler, C., Matsuzawa, M., Knoll, Wolfgang

Electropolymerization of a phenol-modified peptide for use in receptor-ligand interactions studied by surface plasmon resonance (1997)

Kienle, S., Lingler, S., Kraas, W., Offenhäusser, Andreas, Knoll, Wolfgang, Jung, G.

Field-effect transistor array for monitoring electrical activity from mammalian neurons in culture (1997)

Offenhäusser, Andreas, Sprössler, C., Matsuzawa, M., Knoll, Wolfgang

Lateral diffusion in substrate-supported lipid monolayers as a function of ambient relative humidity.

Baumgart, Tobias, Offenhäusser, Andreas

We analyzed the influence of water activity on the lateral self-diffusion of supported phospholipid monolayers. Lipid monolayer membranes were supported by polysaccharide cushions (chitosan and...

Membrane on a Chip: A Functional Tethered Lipid Bilayer Membrane on Silicon Oxide Surfaces

Atanasov, Vladimir, Knorr, Nikolaus, Duran, Randolph S., Ingebrandt, Sven, Offenhäusser, Andreas, Knoll, Wolfgang, ...

Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the...

Cell-Transistor Coupling: Investigation of Potassium Currents Recorded with p- and n-Channel FETs

Wrobel, Günter, Seifert, Reinhard, Ingebrandt, Sven, Enderlein, Jörg, Ecken, Holger, Baumann, Arnd, ...

Microelectronic-based biosensors that allow noninvasive measurement of cell activity are in the focus of current developments, however, the mechanisms underlying the cell-transistor coupling are not...

Lateral diffusion in substrate-supported lipid monolayers as a function of ambient relative humidity.

Baumgart, Tobias, Offenhäusser, Andreas

We analyzed the influence of water activity on the lateral self-diffusion of supported phospholipid monolayers. Lipid monolayer membranes were supported by polysaccharide cushions (chitosan and...

Membrane on a Chip: A Functional Tethered Lipid Bilayer Membrane on Silicon Oxide Surfaces

Atanasov, Vladimir, Knorr, Nikolaus, Duran, Randolph S., Ingebrandt, Sven, Offenhäusser, Andreas, Knoll, Wolfgang, ...

Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the...

Cell-Transistor Coupling: Investigation of Potassium Currents Recorded with p- and n-Channel FETs

Wrobel, Günter, Seifert, Reinhard, Ingebrandt, Sven, Enderlein, Jörg, Ecken, Holger, Baumann, Arnd, ...

Microelectronic-based biosensors that allow noninvasive measurement of cell activity are in the focus of current developments, however, the mechanisms underlying the cell-transistor coupling are not...

Spatially resolved non-invasive chemical stimulation for modulation of signalling in reconstructed neuronal networks

Mourzina, Yulia, Steffen, Alfred, Kaliaguine, Dmitri, Wolfrum, Bernhard, Schulte, Petra, Böcker-Meffert, Simone, ...

Functional coupling of reconstructed neuronal networks with microelectronic circuits has potential for the development of bioelectronic devices, pharmacological assays and medical engineering....

Transmission electron microscopy study of the cell–sensor interface

Wrobel, Günter, Höller, Matthias, Ingebrandt, Sven, Dieluweit, Sabine, Sommerhage, Frank, Bochem, Hans Peter, ...

An emerging number of micro- and nanoelectronics-based biosensors have been developed for non-invasive recordings of physiological cellular activity. The interface between the biological system and...

Iridium Oxide Microelectrode Arrays for In Vitro Stimulation of Individual Rat Neurons from Dissociated Cultures

Eick, Stefan, Wallys, Jens, Hofmann, Boris, Van Ooyen, André, Schnakenberg, Uwe, Ingebrandt, Sven, ...

We present the first in vitro extracellular stimulation of individual neurons from dissociated cultures with iridium oxide (IrOx) electrodes. Microelectrode arrays with sputtered IrOx films (SIROF)...

Andreas Offenhäusser

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