The quantitative single-neuron modeling competition (2008)
Jolivet, Renaud, Schürmann, Felix, Berger, Thomas K., Naud, Richard, Gerstner, Wulfram, Roth, Arnd
As large-scale, detailed network modeling projects are flourishing in the field of computational neuroscience, it is more and more important to design single neuron models that not only capture...
Renaud Jolivet, Arnd Roth, Felix Schürmann, Wulfram Gerstner, Walter Senn, R. Jolivet (b, ...
Single neurons are the fundamental constituents of all nervous systems. Understanding the properties and dynamics of single neurons is therefore one of the key challenges in modern neuroscience....
Feldmeyer, Dirk, Roth, Arnd, Sakmann, Bert
Monosynaptic interlaminar connections between spiny stellate cells in layer 4 (L4), the main cortical recipient layer for thalamic projections, and pyramidal cells in layer 5A (L5A), one of the main...
New biophysical methods for the characterization of signal transfer in neurons (2004)
Many neurons have extensive dendritic trees, and therefore somatic voltage clamp of dendritic synapses is often associated with substantial distortion and attenuation of the synaptic currents. A new...
Broser,Philip J., Schulte,R., Lang,Stefan, Roth,Arnd, Helmchen,Fritjof, Waters,David Jack, ...
Two−photon microscopy in combination with novel fluorescent labeling techniques enables imaging of three−dimensional neuronal morphologies in intact brain tissue. In principle it is now possible...
Broser, Philip J., Schulte, R., Lang, Stefan, Roth, Arnd, Helmchen, Fritjof, Waters, David Jack, ...
Two−photon microscopy in combination with novel fluorescent labeling techniques enables imaging of three−dimensional neuronal morphologies in intact brain tissue. In principle it is now possible...
New biophysical methods for the characterization of signal transfer in neurons / (2004)
Heidelberg, Univ., Diss., 2004.
New biophysical methods for the characterization of signal transfer in neurons (2004)
Many neurons have extensive dendritic trees, and therefore somatic voltage clamp of dendritic synapses is often associated with substantial distortion and attenuation of the synaptic currents. A new...
Lübke,Joachim H. R., Roth,Arnd, Feldmeyer,Dirk, Sakmann,Bert
We have investigated the dendritic and axonal morphology of connected pairs of L4 spiny neurons and L2/3 pyramidal cells in rat barrel cortex. The 'projection' field of the axons of L4 spiny neurons...
Brecht,Michael, Roth,Arnd, Sakmann,Bert
Whole-cell voltage recordings were made in vivo from subsequently reconstructed pyramidal neurons (n = 30) in layer 3 (L3) and layer 2 (L2) of the barrel cortex of urethane-anaesthetised rats....
Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern (2003)
Schaefer,Andreas T., Larkum,Matthew E., Sakmann,Bert, Roth,Arnd
Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic...
Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern (2003)
Schaefer, Andreas T., Larkum, Matthew E., Sakmann, Bert, Roth, Arnd
Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic...
Brecht, Michael, Roth, Arnd, Sakmann, Bert
Whole-cell voltage recordings were made in vivo from subsequently reconstructed pyramidal neurons (n = 30) in layer 3 (L3) and layer 2 (L2) of the barrel cortex of urethane-anaesthetised rats....
Lübke, Joachim H. R., Roth, Arnd, Feldmeyer, Dirk, Sakmann, Bert
We have investigated the dendritic and axonal morphology of connected pairs of L4 spiny neurons and L2/3 pyramidal cells in rat barrel cortex. The 'projection' field of the axons of L4 spiny neurons...
Lübke, Joachim, Roth, Arnd, Feldmeyer, Dirk, Sakmann, Bert
We have investigated the dendritic and axonal morphology of connected pairs of L4 spiny neurons and L2/3 pyramidal cells in rat barrel cortex. The ‘projection’ field of the axons of L4 spiny...
Propagation of action potentials in dendrites depends on dendritic morphology (2001)
Vetter,Philipp, Roth,Arnd, Häusser,Michael
Action potential propagation links information processing in different regions of the dendritic tree. To examine the contribution of dendritic morphology to the efficacy of propagation, simulations...
Simultaneous dendritic and somatic patch-clamp recordings were made from Purkinje cells in cerebellar slices from 12- to 21-day-old rats. Voltage responses to current impulses injected via either the...
Simultaneous dendritic and somatic patch-clamp recordings were made from Purkinje cells in cerebellar slices from 12- to 21-day-old rats. Voltage responses to current impulses injected via either the...
Propagation of action potentials in dendrites depends on dendritic morphology (2001)
Vetter, Philipp, Roth, Arnd, Häusser, Michael
Action potential propagation links information processing in different regions of the dendritic tree. To examine the contribution of dendritic morphology to the efficacy of propagation, simulations...
Competitive calcium binding: implications for dendritic calcium signaling (1998)
Markram,Henry, Roth,Arnd, Helmchen,Fritjof
Action potentials evoke calcium transients in dendrites of neocortical pyramidal neurons with time constants of < 100 ms at physiological temperature. This time period may not be sufficient for...
Competitive calcium binding: implications for dendritic calcium signaling (1998)
Markram, Henry, Roth, Arnd, Helmchen, Fritjof
Action potentials evoke calcium transients in dendrites of neocortical pyramidal neurons with time constants of < 100 ms at physiological temperature. This time period may not be sufficient for...
We introduce a method that permits faithful extraction of the decay time course of the synaptic conductance independent of dendritic geometry and the electrotonic location of the synapse. The method...
Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse (1997)
Geiger,Jörg R. P., Lübke,Joachim H. R., Roth,Arnd, Frotscher,Michael, Jonas,Peter
Glutamatergic transmission at a principal neuron?interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked...
Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells (1997)
1. The properties of glutamate receptor (GluR) channels in outside-out patches from the dendrites and somata of rat cerebellar Purkinje cells in brain slice were studied using fast agonist...
Markram,Henry, Lübke,Joachim H. R., Frotscher,Michael, Roth,Arnd, Sakmann,Bert
1. Dual voltage recordings were made from pairs of adjacent, synaptically connected thick tufted layer 5 pyramidal neurones in brain slices of young rat (14-16 days) somatosensory cortex to examine...
Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse (1997)
Geiger, Jörg R. P., Lübke, Joachim H. R., Roth, Arnd, Frotscher, Michael, Jonas, Peter
Glutamatergic transmission at a principal neuron?interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked...
Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells (1997)
1. The properties of glutamate receptor (GluR) channels in outside-out patches from the dendrites and somata of rat cerebellar Purkinje cells in brain slice were studied using fast agonist...
We introduce a method that permits faithful extraction of the decay time course of the synaptic conductance independent of dendritic geometry and the electrotonic location of the synapse. The method...
Markram, Henry, Lübke, Joachim H. R., Frotscher, Michael, Roth, Arnd, Sakmann, Bert
1. Dual voltage recordings were made from pairs of adjacent, synaptically connected thick tufted layer 5 pyramidal neurones in brain slices of young rat (14-16 days) somatosensory cortex to examine...
Simultaneous dendritic and somatic patch-clamp recordings were made from Purkinje cells in cerebellar slices from 12- to 21-day-old rats. Voltage responses to current impulses injected via either the...
Brecht, Michael, Roth, Arnd, Sakmann, Bert
Whole-cell voltage recordings were made in vivo from subsequently reconstructed pyramidal neurons (n = 30) in layer 3 (L3) and layer 2 (L2) of the barrel cortex of urethane-anaesthetised rats....