Cholestanol: A serum marker to guide LDL cholesterol-lowering therapy (2006)
Hoenig, M. R., Rolfe, B. E., Campbell, J. H.
Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few...
Growth factor regulation of myofibroblast differentiation (2006)
Rolfe, B. E., Zhang, B., Wigan, M. P., Pearson, K., Chen, Y., Pantarat, S., ...
Monocytes/macrophages and foreign body encapsulation in the peritoneal cavity (2006)
Mooney, J. E., Rolfe, B. E., Zhang, B., Sester, P., Campbell, J. H., Campbell, G. R.
Rho and vascular disease (2005)
Rolfe, B. E., Worth, N. F., World, C. J., Campbell, J. H., Campbell, G. R.
The Rho family GTPases are regulatory molecules that link surface receptors to organisation of the actin cytoskeleton and play major roles in fundamental cellular processes. In the vasculature Rho...
Tissue-engineered blood vessels - Alternative to autologous grafts? (2005)
Hoenig, M. R., Campbell, G. R., Rolfe, B. E., Campbell, J. H.
Although vascular bypass grafting remains the mainstay for revascularization for ischemic heart disease and peripheral vascular disease, many patients do not have healthy vessels suitable for...
The effects of leukemia inhibitory factor (LIF) on neointimal formation in injured arteries (2004)
World, C.J., Merrilees, M.J., Beaumont, B., Campbell, G. R., Campbell, J. H., Rolfe, B. E.
Rho expression and activation in vascular smooth muscle cells (2004)
Worth, N. F., Campbell, G. R., Campbell, J. H., Rolfe, B. E.
Phenotypic modulation of smooth muscle cells (SMC) involves dramatic changes in expression and organization of contractile and cytoskeletal proteins, but little is known of how this process is...
Rho and smooth muscle cell phenotype (2003)
Worth, N. F., Rolfe, B. E., Campbell, J. H., Campbell, G. R.
Leukaemia inhibitory factor retards the progression of atherosclerosis (2003)
Rolfe, B. E., Stamatiou, S., World, C., Brown, L. C., Thomas, A., Bingley, J., ...
Objective: Our previous studies showed that the pleiotropic cytokine leukaemia inhibitory factor (LIF) inhibits the de novo formation of experimental atherosclerotic lesions. The present study...
Regulation of LIF receptor expression in vascular smooth muscle (2001)
World, C., Rolfe, B. E., Campbell, J. H.
Previous studies in our laboratory have shown that the pleiotropic cytokine leukemia inhibitory factor (LIF) inhibits neointimal formation and the development and progression of atherosclerotic and...
Song, J., Rolfe, B. E., Hayward, I. P., Campbell, G. R., Campbell, J. H.
When smooth muscle cells are enzyme-dispersed from tissues they lose their original filament architecture and extracellular matrix surrounds. They then reorganize their structural proteins to...
Worth, N. F., Rolfe, B. E., Song, J., Campbell, G. R.
Smooth muscle cells (SMC) exhibit a functional plasticity, modulating from the mature phenotype in which the primary function is contraction, to a less differentiated state with increased capacities...
A role for Rho in smooth muscle phenotypic regulation (2001)
Campbell, G. R., Worth, N. F., Rolfe, B. E.
The role of the small GTP-binding protein Rho in the process of smooth muscle cell (SMC) phenotypic modulation was investigated using cultured rabbit aortic SMCs. Both Rho transcription and Rho...
Song, J., Worth, N. F., Rolfe, B. E., Campbell, G. R., Campbell, J. H.
We have previously demonstrated that or-smooth muscle (alpha -SM) actin is predominantly distributed in the central region and beta -non-muscle (beta -NM) actin in the periphery of cultured rabbit...
ICAM-1expression by vascular smooth muscle cells is phenotype-dependent (2000)
Rolfe, B. E., Muddiman, J. D., Smith, N. J., Campbell, G. R., Campbell, J. H.
Atherosclerosis is an inflammatory disease characterised by increased expression of adhesion molecules for leukocytes on both the surface of dysfunctional endothelium and on smooth muscle cells (SMC)...
Song, J., Rolfe, B. E., Hayward, I. P., Campbell, G. R., Campbell, J. H.
The growth, behavior, and contractile protein expression of rabbit aortic smooth muscle cells (SMC) grown on, between layers, or within a collagen gel was investigated by confocal laser scanning...
Cuff-induced intimal thickening in the carotid artery of the marmoset (2000)
Badorrek, B., Rolfe, B. E., Campbell, J. H., Campbell, G. R.
Behaviour of rabbit aortic smooth muscle cells grown in three-dimensional collagen gel (1999)
Song, J., Rolfe, B. E., Hayward, I. P., Campbell, G. R., Campbell, J. H.
Modified vascular smooth muscle cell behaviour in vitro by extracellular matrix (1999)
Song, J., Rolfe, B. E., Worth, N., Campbell, J. H., Campbell, G. R., Hayward, I. P.
Song, J., Rolfe, B. E., Campbell, J. H., Campbell, G. R.
To investigate changes in the three-dimensional microfilament architecture of vascular smooth muscle cells (SMC) during the process of phenotypic modulation, rabbit aortic SMCs cultured under...
Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype (1998)
Song, J., Wan, Y., Rolfe, B. E., Campbell, J. H., Campbell, G. R.
To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E-2) on phenotypic modulation and proliferation of rabbit aortic SMC...