Genetic and molecular definition of complementation group D in MHC class II deficiency (1998)
Fondaneche, MC, Villard, J, Wiszniewski, W, Jouanguy, E, Etzioni, A, Le Deist, F, ...
DNA binding properties of a chemically synthesized DNA binding domain of hRFX1 (1998)
Cornille, F, Emery, P, Schuler, W, Lenoir, C, Mach, B, Roques, BP, ...
A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. (1997)
Conrad, B, Weissmahr, R N, Böni, J, Arcari, R, Schüpbach, J, Mach, B
Microbial superantigens (SAGs) have been implicated in the pathogenesis of human autoimmune diseases. Preferential expansion of the Vveta7 T cell receptor positive T cell subset in patients suffering...
Emery, P., Strubin, M., Hofmann, K., Bucher, P., Mach, B., Reith, W.
The RFX DNA binding domain is a novel motif that has been conserved in a growing number of dimeric DNA-binding proteins, having diverse regulatory functions, in eukaryotic organisms ranging from...
Reith, W, Herrero-Sanchez, C, Kobr, M, Silacci, P, Berte, C, Barras, E, ...
Gönczy, P., Reith, W., Barras, E., Lisowska-Grospierre, B., Griscelli, C., Hadam, M. R., ...
A defect in a trans-regulatory factor which controls major histocompatibility complex class II gene expression is responsible for an inherited form of immunodeficiency with a lack of expression of...
Insertion of a rabbit {beta}-globin gene sequence into an E.coli plasmid (1975)
Rougeon, F., Kourilsky, P., Mach, B.
Double stranded DNA has been synthesized in vitro from rabbit globin messenger RNA and elongated with homopolymeric dG tails. An E.coli plasmid was cleaved by EcoRI. The cohesive ends were repaired...
Reith, W, Siegrist, C A, Durand, B, Barras, E, Mach, B
Transcription of major histocompatibility complex (MHC) class II genes is controlled largely by the conserved promoter elements called the X and Y boxes. We show here that RFX, the X box-binding...
Tiercy, J M, Morel, C, Freidel, A C, Zwahlen, F, Gebuhrer, L, Bétuel, H, ...
As the demand for donors for bone marrow transplantation increases, the use of HLA-matched, genetically unrelated donors represents a promising strategy. It is well documented that the clinical...
RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.
Emery, P, Durand, B, Mach, B, Reith, W
Until recently, the RFX family of DNA binding proteins consisted exclusively of four mammalian members (RFX1-RFX4) characterized by a novel highly conserved DNA binding domain. Strong conservation of...
DNA binding properties of a chemically synthesized DNA binding domain of hRFX1.
Cornille, F, Emery, P, Schüler, W, Lenoir, C, Mach, B, Roques, B P, ...
The RFX DNA binding domain (DBD) is a novel highly conserved motif belonging to a large number of dimeric DNA binding proteins which have diverse regulatory functions in eukaryotic organisms, ranging...
A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity.
Emery, P, Strubin, M, Hofmann, K, Bucher, P, Mach, B, Reith, W
The RFX DNA binding domain is a novel motif that has been conserved in a growing number of dimeric DNA-binding proteins, having diverse regulatory functions, in eukaryotic organisms ranging from...
Bontron, S, Ucla, C, Mach, B, Steimle, V
Major histocompatibility complex class II (MHC-II) molecules present peptide antigens to CD4-positive T cells and are of critical importance for the immune response. The MHC-II transactivator CIITA...
Tiercy, J M, Gorski, J, Jeannet, M, Mach, B
Recent progress in the molecular biology of human major histocompatibility complex class II genes (HLA-DP, -DQ, -DR) have shown that the genetic complexity and allelic polymorphism are greater than...
Reith, W, Barras, E, Satola, S, Kobr, M, Reinhart, D, Sanchez, C H, ...
The regulation of major histocompatibility complex class II gene expression is directly involved in the control of normal and abnormal immune responses. In humans, HLA-DR, -DQ, and -DP class II...
Ucla, C, Roux-Lombard, P, Fey, S, Dayer, J M, Mach, B
IL-1 alpha, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) gene expression is induced by LPS (endotoxin) in monocytes/macrophages and in some monocytic cell lines. IFN gamma and 1...
Angelini, G, De Preval, C, Gorski, J, Mach, B
The human major histocompatibility complex class II antigens of the HLA-D are highly polymorphic, surface proteins essential in the cellular interactions necessary for an immune response. The...
Cloning of multiple copies of immunoglobulin variable kappa genes in cosmid vectors.
Cattaneo, R, Gorski, J, Mach, B
The possibility of cloning large segments of DNA in cosmid vectors offers distinct advantages, in particular for the study of multigene families. Large size fragments of mouse embryo DNA were...
A precise quantitation of gene number by saturation hybridization using cloned DNA.
This paper describes a precise method of gene titration as applied to the alpha- and beta-globin genes in the mouse. The three salient features of the method are: (i) the use of saturation...
Regulatory factor-X binding to mutant HLA-DRA promoter sequences.
Hasegawa, S L, Sloan, J H, Reith, W, Mach, B, Boss, J M
The class II genes of the major histocompatibility complex (MHC) encode a family of cell surface glycoproteins that present processed antigen to the T cell receptor. Class II genes are regulated...
No detectable reiteration of genes coding for mouse MOPC 41 immunoglobulin light-chain mRNA.
Farace, M G, Aellen, M F, Briand, P A, Faust, C H, Vassalli, P, Mach, B
RNA fractions rich in immunoglobulin light (L)-chain mRNA were isolated from mouse myeloma MOPC 41 by procedures previously described, and chemically labeled with 125I. These RNA fractions were...
Insertion of a rabbit beta-globin gene sequence into an E. coli plasmid.
Rougeon, F, Kourilsky, P, Mach, B
Double stranded DNA has been synthesized in vitro from rabbit globin messenger RNA and elongated with homopolymeric dG tails. An E. coli plasmid was cleaved by EcoRI. The cohesive ends were repaired...
McGarvey, M J, Sheybani, E, Loche, M P, Perrin, L, Mach, B
The key steps in the development of a malaria vaccine through gene cloning are the identification of the proteins involved in host protective immunity and the cloning, identification, and expression...
Gorski, J, Rollini, P, Long, E, Mach, B
The class II products of the major histocompatibility complex, also called Ia antigens, are composed of two polypeptide chains, the alpha and beta chains, both encoded within the major...
Isolation of cDNA clones encoding HLA-DR alpha chains.
Wake, C T, Long, E O, Strubin, M, Gross, N, Accolla, R, Carrel, S, ...
HLA-DR antigens, the human equivalent of mouse Ia antigens, are multimeric surface glycoproteins characterized by a high degree of allelic polymorphism. They are expressed specifically on macrophages...
Isolation of distinct cDNA clones encoding HLA-DR beta chains by use of an expression assay.
Long, E O, Wake, C T, Strubin, M, Gross, N, Accolla, R S, Carrel, S, ...
cDNA clones encoding different human Ia antigen beta chains were isolated by use of a complementation-expression assay in Xenopus oocytes. The assay was based on two previous findings. First, oocytes...
Reith, W, Ucla, C, Barras, E, Gaud, A, Durand, B, Herrero-Sanchez, C, ...
RFX1 is a transactivator of human hepatitis B virus enhancer I. We show here that RFX1 belongs to a previously unidentified family of DNA-binding proteins of which we have cloned three members, RFX1,...
Herrero Sanchez, C, Reith, W, Silacci, P, Mach, B
The X box of major histocompatibility complex class II promoters is essential for proper expression of class II genes. Here we show that two distinct protein-DNA complexes (A and B), which exhibit...
Kobr, M, Reith, W, Herrero-Sanchez, C, Mach, B
The regulation of major histocompatibility complex (MHC) class II gene expression is a key feature of the control of normal and abnormal immune responses. In humans, class II alpha - and beta-chain...
Gönczy, P, Reith, W, Barras, E, Lisowska-Grospierre, B, Griscelli, C, Hadam, M R, ...
A defect in a trans-regulatory factor which controls major histocompatibility complex class II gene expression is responsible for an inherited form of immunodeficiency with a lack of expression of...
Siegrist, C A, Durand, B, Emery, P, David, E, Hearing, P, Mach, B, ...
Hepatitis B virus gene expression is to a large extent under the control of enhancer I (EnhI). The activity of EnhI is strictly dependent on the enhancer factor C (EF-C) site, an inverted repeat that...
Isolation of cDNA clones for the p33 invariant chain associated with HLA-DR antigens.
Long, E O, Strubin, M, Wake, C T, Gross, N, Carrel, S, Goodfellow, P, ...
HLA-DR antigens are polymorphic cell surface glycoproteins involved in the control of the immune response in man. They consist of two subunits, the alpha and the beta chains. In addition, an...
Faust, C. H., Diggelmann, H., Mach, B.
As previously shown, purified 14S RNA of mouse myeloma MOPC-41 forms a single peak on sucrose gradients and gel electrophoresis and codes for a single polypeptide chain, the immunoglobulin light...
Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.
Rollini, P, Mach, B, Gorski, J
The predominant class II, or Ia, antigen of the human major histocompatibility complex is HLA-DR. It consists of an alpha and a beta chain, the latter being responsible for the remarkable...
Deletion mapping of HLA and chromosome 6p genes.
Levine, F, Erlich, H, Mach, B, Leach, R, White, R, Pious, D
We have analyzed a set of heterozygous mutants with deletions that encompass parts of HLA and surrounding regions of chromosome 6p. By a combination of Southern blotting, serologic, enzymatic, and...
Lisowska-Grospierre, B, Charron, D J, De Préval, C, Durandy, A, Griscelli, C, Mach, B
Patients with an autosomal recessive combined immunodeficiency are characterized by an HLA negative phenotype of activated T and B lymphocytes. To determine the molecular basis of this syndrome we...
Two approaches have been explored for the synthesis of double-stranded DNA from single-stranded DNA template complementary to rabbit 9S globin mRNA (cDNA). (i) cDNA was elongated with dCMP or dTMP...
Mach, B., Faust, C., Vassalli, P.
Polysomes released from microsomes of MOPC 41 mouse myeloma were used to prepare a poly(A)-containing fraction of RNA by chromatography on poly-(dT)-cellulose. From that fraction, a 14S RNA species...
Enzymatic Synthesis of DNA Complementary to Purified 14S Messenger RNA of Immunoglobulin Light Chain
Diggelmann, H., Faust, C. H., Mach, B.
The 14S messenger RNA, which contains poly(adenylic acid), of MOPC 41 (mouse plasmocytoma) immunoglobulin light chain, purified to a single peak as shown by polyacrylamide gel electrophoresis, was...
Analysis of HLA-D micropolymorphism by a simple procedure: RNA oligonucleotide hybridization.
Ucla, C, Van Rood, J J, Gorski, J, Mach, B
Recent progress in the molecular genetics of HLA class II antigens has revealed the existence of multiple loci and of a large degree of polymorphism, with more individual alleles than was expected....
Long, E O, Gross, N, Wake, C T, Mach, J P, Carrel, S, Accolla, R, ...
HLA-DR antigens are polymorphic cell surface glycoproteins, expressed primarily in B lymphocytes and macrophages, which are thought to play an important role in the immune response. Two polypeptide...
Origin of transcription of a mouse immunoglobulin light chain gene.
Although the organization, the structure, and the somatic rearrangement of immunoglobulin genes have been studied in detail, there is no information regarding the precise origin of transcription of...
Long, E O, Wake, C T, Gorski, J, Mach, B
At least three polymorphic class II antigens are encoded in the human major histocompatibility complex (HLA): DR, DC and SB. cDNA clones encoding beta chains of HLA-DR antigen, derived from mRNA of a...
Strubin, M, Mach, B, Long, E O
A non-polymorphic polypeptide is associated intracellularly with the alpha and beta chains of murine Ia antigens and of human HLA-DR antigens. The exact role and the structure of this invariant chain...
Néel, D, Merlu, B, Turpin, E, Rabourdin-Combe, C, Mach, B, Goussault, Y, ...
In order to determine the factors that influence the glycosylation of an integral membrane protein, we investigated the N-glycosylation of a molecule of the human major histocompatibility complex...
The Ia antigen-associated invariant chain (In) exists in humans as four related polypeptides, p33, p35, p41 and p43, all associated with HLA-class II antigens. As described previously, two of these...
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
Durand, B, Sperisen, P, Emery, P, Barras, E, Zufferey, M, Mach, B, ...
Major Histocompatibility Complex class II (MHC-II) deficiency is a disease of gene regulation that provides a unique opportunity for the genetic dissection of the molecular mechanisms controlling...
Muhlethaler-Mottet, A, Otten, L A, Steimle, V, Mach, B
The highly complex pattern of expression of major histocompatibility complex class II (MHC-II) molecules determines both the immune repertoire during development and subsequently the triggering and...
Durand, B, Kobr, M, Reith, W, Mach, B
Major histocompatibility complex (MHC) class II deficiency, or bare lymphocyte syndrome (BLS), is a disease of gene regulation. Patients with BLS have been classified into at least three...
Tiercy, J M, Sanchez-Mazas, A, Excoffier, L, Shi-Isaac, X, Jeannet, M, Mach, B, ...
HLA class II loci are useful markers in human population genetics, because they are extremely variable and because new molecular techniques allow large-scale analysis of DNA allele frequencies....
Reith, W, Siegrist, C A, Durand, B, Barras, E, Mach, B
Transcription of major histocompatibility complex (MHC) class II genes is controlled largely by the conserved promoter elements called the X and Y boxes. We show here that RFX, the X box-binding...
Tiercy, J M, Morel, C, Freidel, A C, Zwahlen, F, Gebuhrer, L, Bétuel, H, ...
As the demand for donors for bone marrow transplantation increases, the use of HLA-matched, genetically unrelated donors represents a promising strategy. It is well documented that the clinical...
RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.
Emery, P, Durand, B, Mach, B, Reith, W
Until recently, the RFX family of DNA binding proteins consisted exclusively of four mammalian members (RFX1-RFX4) characterized by a novel highly conserved DNA binding domain. Strong conservation of...
DNA binding properties of a chemically synthesized DNA binding domain of hRFX1.
Cornille, F, Emery, P, Schüler, W, Lenoir, C, Mach, B, Roques, B P, ...
The RFX DNA binding domain (DBD) is a novel highly conserved motif belonging to a large number of dimeric DNA binding proteins which have diverse regulatory functions in eukaryotic organisms, ranging...
A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity.
Emery, P, Strubin, M, Hofmann, K, Bucher, P, Mach, B, Reith, W
The RFX DNA binding domain is a novel motif that has been conserved in a growing number of dimeric DNA-binding proteins, having diverse regulatory functions, in eukaryotic organisms ranging from...
Bontron, S, Ucla, C, Mach, B, Steimle, V
Major histocompatibility complex class II (MHC-II) molecules present peptide antigens to CD4-positive T cells and are of critical importance for the immune response. The MHC-II transactivator CIITA...
Tiercy, J M, Gorski, J, Jeannet, M, Mach, B
Recent progress in the molecular biology of human major histocompatibility complex class II genes (HLA-DP, -DQ, -DR) have shown that the genetic complexity and allelic polymorphism are greater than...
Reith, W, Barras, E, Satola, S, Kobr, M, Reinhart, D, Sanchez, C H, ...
The regulation of major histocompatibility complex class II gene expression is directly involved in the control of normal and abnormal immune responses. In humans, HLA-DR, -DQ, and -DP class II...
Ucla, C, Roux-Lombard, P, Fey, S, Dayer, J M, Mach, B
IL-1 alpha, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) gene expression is induced by LPS (endotoxin) in monocytes/macrophages and in some monocytic cell lines. IFN gamma and 1...
Angelini, G, De Preval, C, Gorski, J, Mach, B
The human major histocompatibility complex class II antigens of the HLA-D are highly polymorphic, surface proteins essential in the cellular interactions necessary for an immune response. The...
Cloning of multiple copies of immunoglobulin variable kappa genes in cosmid vectors.
Cattaneo, R, Gorski, J, Mach, B
The possibility of cloning large segments of DNA in cosmid vectors offers distinct advantages, in particular for the study of multigene families. Large size fragments of mouse embryo DNA were...
A precise quantitation of gene number by saturation hybridization using cloned DNA.
This paper describes a precise method of gene titration as applied to the alpha- and beta-globin genes in the mouse. The three salient features of the method are: (i) the use of saturation...
Regulatory factor-X binding to mutant HLA-DRA promoter sequences.
Hasegawa, S L, Sloan, J H, Reith, W, Mach, B, Boss, J M
The class II genes of the major histocompatibility complex (MHC) encode a family of cell surface glycoproteins that present processed antigen to the T cell receptor. Class II genes are regulated...
No detectable reiteration of genes coding for mouse MOPC 41 immunoglobulin light-chain mRNA.
Farace, M G, Aellen, M F, Briand, P A, Faust, C H, Vassalli, P, Mach, B
RNA fractions rich in immunoglobulin light (L)-chain mRNA were isolated from mouse myeloma MOPC 41 by procedures previously described, and chemically labeled with 125I. These RNA fractions were...
Insertion of a rabbit beta-globin gene sequence into an E. coli plasmid.
Rougeon, F, Kourilsky, P, Mach, B
Double stranded DNA has been synthesized in vitro from rabbit globin messenger RNA and elongated with homopolymeric dG tails. An E. coli plasmid was cleaved by EcoRI. The cohesive ends were repaired...
McGarvey, M J, Sheybani, E, Loche, M P, Perrin, L, Mach, B
The key steps in the development of a malaria vaccine through gene cloning are the identification of the proteins involved in host protective immunity and the cloning, identification, and expression...
Gorski, J, Rollini, P, Long, E, Mach, B
The class II products of the major histocompatibility complex, also called Ia antigens, are composed of two polypeptide chains, the alpha and beta chains, both encoded within the major...
Isolation of cDNA clones encoding HLA-DR alpha chains.
Wake, C T, Long, E O, Strubin, M, Gross, N, Accolla, R, Carrel, S, ...
HLA-DR antigens, the human equivalent of mouse Ia antigens, are multimeric surface glycoproteins characterized by a high degree of allelic polymorphism. They are expressed specifically on macrophages...
Isolation of distinct cDNA clones encoding HLA-DR beta chains by use of an expression assay.
Long, E O, Wake, C T, Strubin, M, Gross, N, Accolla, R S, Carrel, S, ...
cDNA clones encoding different human Ia antigen beta chains were isolated by use of a complementation-expression assay in Xenopus oocytes. The assay was based on two previous findings. First, oocytes...
Reith, W, Ucla, C, Barras, E, Gaud, A, Durand, B, Herrero-Sanchez, C, ...
RFX1 is a transactivator of human hepatitis B virus enhancer I. We show here that RFX1 belongs to a previously unidentified family of DNA-binding proteins of which we have cloned three members, RFX1,...
Durand, B, Kobr, M, Reith, W, Mach, B
Major histocompatibility complex (MHC) class II deficiency, or bare lymphocyte syndrome (BLS), is a disease of gene regulation. Patients with BLS have been classified into at least three...
Herrero Sanchez, C, Reith, W, Silacci, P, Mach, B
The X box of major histocompatibility complex class II promoters is essential for proper expression of class II genes. Here we show that two distinct protein-DNA complexes (A and B), which exhibit...
Kobr, M, Reith, W, Herrero-Sanchez, C, Mach, B
The regulation of major histocompatibility complex (MHC) class II gene expression is a key feature of the control of normal and abnormal immune responses. In humans, class II alpha - and beta-chain...
Gönczy, P, Reith, W, Barras, E, Lisowska-Grospierre, B, Griscelli, C, Hadam, M R, ...
A defect in a trans-regulatory factor which controls major histocompatibility complex class II gene expression is responsible for an inherited form of immunodeficiency with a lack of expression of...
Siegrist, C A, Durand, B, Emery, P, David, E, Hearing, P, Mach, B, ...
Hepatitis B virus gene expression is to a large extent under the control of enhancer I (EnhI). The activity of EnhI is strictly dependent on the enhancer factor C (EF-C) site, an inverted repeat that...
Isolation of cDNA clones for the p33 invariant chain associated with HLA-DR antigens.
Long, E O, Strubin, M, Wake, C T, Gross, N, Carrel, S, Goodfellow, P, ...
HLA-DR antigens are polymorphic cell surface glycoproteins involved in the control of the immune response in man. They consist of two subunits, the alpha and the beta chains. In addition, an...
Faust, C. H., Diggelmann, H., Mach, B.
As previously shown, purified 14S RNA of mouse myeloma MOPC-41 forms a single peak on sucrose gradients and gel electrophoresis and codes for a single polypeptide chain, the immunoglobulin light...
Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.
Rollini, P, Mach, B, Gorski, J
The predominant class II, or Ia, antigen of the human major histocompatibility complex is HLA-DR. It consists of an alpha and a beta chain, the latter being responsible for the remarkable...
Deletion mapping of HLA and chromosome 6p genes.
Levine, F, Erlich, H, Mach, B, Leach, R, White, R, Pious, D
We have analyzed a set of heterozygous mutants with deletions that encompass parts of HLA and surrounding regions of chromosome 6p. By a combination of Southern blotting, serologic, enzymatic, and...
Lisowska-Grospierre, B, Charron, D J, De Préval, C, Durandy, A, Griscelli, C, Mach, B
Patients with an autosomal recessive combined immunodeficiency are characterized by an HLA negative phenotype of activated T and B lymphocytes. To determine the molecular basis of this syndrome we...
Two approaches have been explored for the synthesis of double-stranded DNA from single-stranded DNA template complementary to rabbit 9S globin mRNA (cDNA). (i) cDNA was elongated with dCMP or dTMP...
Mach, B., Faust, C., Vassalli, P.
Polysomes released from microsomes of MOPC 41 mouse myeloma were used to prepare a poly(A)-containing fraction of RNA by chromatography on poly-(dT)-cellulose. From that fraction, a 14S RNA species...
Enzymatic Synthesis of DNA Complementary to Purified 14S Messenger RNA of Immunoglobulin Light Chain
Diggelmann, H., Faust, C. H., Mach, B.
The 14S messenger RNA, which contains poly(adenylic acid), of MOPC 41 (mouse plasmocytoma) immunoglobulin light chain, purified to a single peak as shown by polyacrylamide gel electrophoresis, was...
Analysis of HLA-D micropolymorphism by a simple procedure: RNA oligonucleotide hybridization.
Ucla, C, Van Rood, J J, Gorski, J, Mach, B
Recent progress in the molecular genetics of HLA class II antigens has revealed the existence of multiple loci and of a large degree of polymorphism, with more individual alleles than was expected....
Long, E O, Gross, N, Wake, C T, Mach, J P, Carrel, S, Accolla, R, ...
HLA-DR antigens are polymorphic cell surface glycoproteins, expressed primarily in B lymphocytes and macrophages, which are thought to play an important role in the immune response. Two polypeptide...
Origin of transcription of a mouse immunoglobulin light chain gene.
Although the organization, the structure, and the somatic rearrangement of immunoglobulin genes have been studied in detail, there is no information regarding the precise origin of transcription of...
Long, E O, Wake, C T, Gorski, J, Mach, B
At least three polymorphic class II antigens are encoded in the human major histocompatibility complex (HLA): DR, DC and SB. cDNA clones encoding beta chains of HLA-DR antigen, derived from mRNA of a...
Strubin, M, Mach, B, Long, E O
A non-polymorphic polypeptide is associated intracellularly with the alpha and beta chains of murine Ia antigens and of human HLA-DR antigens. The exact role and the structure of this invariant chain...
Néel, D, Merlu, B, Turpin, E, Rabourdin-Combe, C, Mach, B, Goussault, Y, ...
In order to determine the factors that influence the glycosylation of an integral membrane protein, we investigated the N-glycosylation of a molecule of the human major histocompatibility complex...
The Ia antigen-associated invariant chain (In) exists in humans as four related polypeptides, p33, p35, p41 and p43, all associated with HLA-class II antigens. As described previously, two of these...
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
Durand, B, Sperisen, P, Emery, P, Barras, E, Zufferey, M, Mach, B, ...
Major Histocompatibility Complex class II (MHC-II) deficiency is a disease of gene regulation that provides a unique opportunity for the genetic dissection of the molecular mechanisms controlling...
Muhlethaler-Mottet, A, Otten, L A, Steimle, V, Mach, B
The highly complex pattern of expression of major histocompatibility complex class II (MHC-II) molecules determines both the immune repertoire during development and subsequently the triggering and...
Tiercy, J M, Sanchez-Mazas, A, Excoffier, L, Shi-Isaac, X, Jeannet, M, Mach, B, ...
HLA class II loci are useful markers in human population genetics, because they are extremely variable and because new molecular techniques allow large-scale analysis of DNA allele frequencies....
Ulevitch, R. J., Kline, L., Schreiber, R. D., Pingel, J., Amaldi, I., Reith, W., ...
Class I and class II major histocompatibility complex (MHC) gene products are key recognition units in the induction and regulation of the immune response. Expression of class I and class II may be...