The research presented in this thesis contributes to the understanding of the precise fusion mechanism of alphaviruses and possibly other viruses having class II fusion proteins. Although the results...
Smit, Jolanda M., Waarts, Barry-Lee, Kimata, Koji, Klimstra, William B., Bittman, Robert, Wilschut, Jan
Passage of Sindbis virus (SIN) in BHK-21 cells has been shown to select for virus mutants with high affinity for the glycosaminoglycan heparan sulfate (HS). Three loci in the viral spike protein E2...
Reversible Acid-Induced Inactivation of the Membrane Fusion Protein of Semliki Forest Virus
Waarts, Barry-Lee, Smit, Jolanda M., Aneke, Onwuchekwa J. C., McInerney, Gerald M., Liljeström, Peter, Bittman, Robert, ...
Previously, it has been shown that the exposure of Semliki Forest virus (SFV) to a mildly acidic environment induces a rapid and complete loss of the ability of the virus to bind and fuse to target...
Smit, Jolanda M., Waarts, Barry-Lee, Kimata, Koji, Klimstra, William B., Bittman, Robert, Wilschut, Jan
Passage of Sindbis virus (SIN) in BHK-21 cells has been shown to select for virus mutants with high affinity for the glycosaminoglycan heparan sulfate (HS). Three loci in the viral spike protein E2...
Reversible Acid-Induced Inactivation of the Membrane Fusion Protein of Semliki Forest Virus
Waarts, Barry-Lee, Smit, Jolanda M., Aneke, Onwuchekwa J. C., McInerney, Gerald M., Liljeström, Peter, Bittman, Robert, ...
Previously, it has been shown that the exposure of Semliki Forest virus (SFV) to a mildly acidic environment induces a rapid and complete loss of the ability of the virus to bind and fuse to target...
Van Der Schaar, Hilde M., Rust, Michael J., Waarts, Barry-Lee, Van Der Ende-Metselaar, Heidi, Kuhn, Richard J., Wilschut, Jan, ...
In this study, we investigated the cell entry characteristics of dengue virus (DENV) type 2 strain S1 on mosquito, BHK-15, and BS-C-1 cells. The concentration of virus particles measured by...