Ormandy, CJ, Camus, A, Barra, J, Damotte, D, Lucas, B, Buteau, H, ...
Linkage mapping of murine homolog of the yeast SPT6 gene to MMU11B1 (1996)
Ramamoorthy, S., Morahan, G., Babinet, C., King, E., Blackburn, C.C., ...
Peer Reviewed
Transgenic mice carrying an Xist-containing YAC (1996)
Heard, E, Kress, C, Mongelard, F, Courtier, B, Rougeulle, C, Ashworth, A, ...
Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., ...
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of...
Lavenu, A, Pistoi, S, Pournin, S, Babinet, C, Morello, D
In vivo, the steady-state level of c-myc mRNA is mainly controlled by posttranscriptional mechanisms. Using a panel of transgenic mice in which various versions of the human c-myc proto-oncogene were...
Exon 2-mediated c-myc mRNA decay in vivo is independent of its translation.
Pistoi, S, Roland, J, Babinet, C, Morello, D
We have previously shown that the steady-state level of c-myc mRNA in vivo is primarily controlled by posttranscriptional regulatory mechanisms. To identify the sequences involved in this process, we...
Negative regulation of early polyomavirus expression in mouse embryonal carcinoma cells.
Embryonal carcinoma cells are resistant to infection by polyomavirus (Py). We showed that this block was partially removed by inhibiting protein synthesis temporarily. The block was also partially...
Farza, H, Hadchouel, M, Scotto, J, Tiollais, P, Babinet, C, Pourcel, C
We have sought to address the problem of the host and tissue specificity of the hepatitis B virus (HBV) by using transgenic mice obtained after injection of head-to-tail dimers of the HBV genome....
Farza, H, Salmon, A M, Hadchouel, M, Moreau, J L, Babinet, C, Tiollais, P, ...
We have investigated the basis for liver-specific and sex-linked expression of hepatitis B surface antigen (HBsAg) gene in transgenic mice by monitoring the level of liver HBsAg mRNA and serum HBsAg...
Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice.
Goodhardt, M, Cavelier, P, Akimenko, M A, Lutfalla, G, Babinet, C, Rougeon, F
To determine whether a foreign unrearranged immunoglobulin gene can be functionally rearranged and expressed in vivo, a rabbit b9 kappa light chain gene construct containing a single germ-line kappa...
Goodhardt, M, Babinet, C, Lutfalla, G, Kallenbach, S, Cavelier, P, Rougeon, F
We have produced transgenic mice which synthesize chimeric mouse-rabbit immunoglobulin (Ig) kappa light chains following in vivo recombination of an injected unrearranged kappa gene. The exogenous...
Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation.
Brûlet, P, Babinet, C, Kemler, R, Jacob, F
Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm...
Morello, D, Fitzgerald, M J, Babinet, C, Fausto, N
We investigated the mechanisms of regulation of c-myc, c-fos, and c-jun at the early stages of liver regeneration in mice. We show that the transient increase in steady-state levels of c-myc mRNA at...
Altered expression of heat shock proteins in embryonal carcinoma and mouse early embryonic cells.
Morange, M, Diu, A, Bensaude, O, Babinet, C
In a previous paper, we have shown that in the absence of stress, mouse embryonal carcinoma cells, like mouse early embryo multipotent cells, synthesize high levels of 89- and 70-kilodalton heat...
Identification of a paternal developmental effect on the cytoplasm of one-cell-stage mouse embryos.
Matings of female DDK mice with males of the BALB/c strain are sterile, whereas reciprocal crosses are normally fertile. We used nuclear transplantation between the hybrid eggs of these two strains...
Expression of the cytokeratin endo A gene during early mouse embryogenesis.
Duprey, P, Morello, D, Vasseur, M, Babinet, C, Condamine, H, Brûlet, P, ...
Expression of cytokeratin endo A has been analyzed during mouse blastocyst formation and embryonal carcinoma cell differentiation. To study the regulation of endo A expression, nuclease S1 mapping...
Embryonal carcinoma antigen and the T/t locus of the mouse.
Kemler, R, Babinet, C, Condamine, H, Gachelin, G, Guenet, J L, Jacob, F
The presence of the F9 antigen and of four other antigens related to the T/t locus of the mouse was investigated by immunofluorescence on preimplantation embryos. In morulae heterozygous for any of...
Surface antigen in early differentiation.
Kemler, R, Babinet, C, Eisen, H, Jacob, F
Addition of Fab fragments from rabbit antiserum to surface antigen F9 to 2-cell stage mouse embryos in culture does not alter cleavage; however, the addition prevents culture does not alter cleavage;...
Klarsfeld, A, Bessereau, J L, Salmon, A M, Triller, A, Babinet, C, Changeux, J P
We have obtained transgenic mice expressing nuclearly targeted beta-galactosidase (nls-beta-gal) under the control of a chicken acetylcholine receptor alpha-subunit promoter. The expression of the...
Terzi, F, Henrion, D, Colucci-Guyon, E, Federici, P, Babinet, C, Levy, B I, ...
Modulation of vascular tone by chemical and mechanical stimuli is a crucial adaptive phenomenon which involves cytoskeleton elements. Disruption, by homologous recombination, of the gene encoding...
Impaired flow-induced dilation in mesenteric resistance arteries from mice lacking vimentin.
Henrion, D, Terzi, F, Matrougui, K, Duriez, M, Boulanger, C M, Colucci-Guyon, E, ...
The intermediate filament vimentin might play a key role in vascular resistance to mechanical stress. We investigated the responses to pressure (tensile stress) and flow (shear stress) of mesenteric...
Tronik, D, Dreyfus, M, Babinet, C, Rougeon, F
The Ren-2 gene encoding the mouse submaxillary gland (SMG) renin was microinjected into the pronuclei of fertilized eggs from mice carrying only the Ren-1 gene. In addition to the whole transcription...
Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice.
Morello, D, Moore, G, Salmon, A M, Yaniv, M, Babinet, C
Transgenic mice carrying the H-2K/human growth hormone (hGH) fusion gene were produced by microinjecting into the pronucleus of fertilized eggs DNA molecules containing 2 kb of the 5' flanking...
Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).
Reyes, J C, Barra, J, Muchardt, C, Camus, A, Babinet, C, Yaniv, M
The mammalian SWI-SNF complex is an evolutionarily conserved, multi-subunit machine, involved in chromatin remodelling during transcriptional activation. Within this complex, the BRM (SNF2alpha) and...
BALB/c alleles at modifier loci increase the severity of the maternal effect of the "DDK syndrome".
Le Bras, S, Cohen-Tannoudji, M, Kress, C, Vandormael-Pournin, S, Babinet, C, Baldacci, P
The Om locus was first described in the DDK inbred mouse strain: DDK mice carry a mutation at Om resulting in a parental effect lethality of F(1) embryos. When DDK females are mated with males of...
Lavenu, A, Pistoi, S, Pournin, S, Babinet, C, Morello, D
In vivo, the steady-state level of c-myc mRNA is mainly controlled by posttranscriptional mechanisms. Using a panel of transgenic mice in which various versions of the human c-myc proto-oncogene were...
Exon 2-mediated c-myc mRNA decay in vivo is independent of its translation.
Pistoi, S, Roland, J, Babinet, C, Morello, D
We have previously shown that the steady-state level of c-myc mRNA in vivo is primarily controlled by posttranscriptional regulatory mechanisms. To identify the sequences involved in this process, we...
Negative regulation of early polyomavirus expression in mouse embryonal carcinoma cells.
Embryonal carcinoma cells are resistant to infection by polyomavirus (Py). We showed that this block was partially removed by inhibiting protein synthesis temporarily. The block was also partially...
Farza, H, Hadchouel, M, Scotto, J, Tiollais, P, Babinet, C, Pourcel, C
We have sought to address the problem of the host and tissue specificity of the hepatitis B virus (HBV) by using transgenic mice obtained after injection of head-to-tail dimers of the HBV genome....
Farza, H, Salmon, A M, Hadchouel, M, Moreau, J L, Babinet, C, Tiollais, P, ...
We have investigated the basis for liver-specific and sex-linked expression of hepatitis B surface antigen (HBsAg) gene in transgenic mice by monitoring the level of liver HBsAg mRNA and serum HBsAg...
Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice.
Goodhardt, M, Cavelier, P, Akimenko, M A, Lutfalla, G, Babinet, C, Rougeon, F
To determine whether a foreign unrearranged immunoglobulin gene can be functionally rearranged and expressed in vivo, a rabbit b9 kappa light chain gene construct containing a single germ-line kappa...
Goodhardt, M, Babinet, C, Lutfalla, G, Kallenbach, S, Cavelier, P, Rougeon, F
We have produced transgenic mice which synthesize chimeric mouse-rabbit immunoglobulin (Ig) kappa light chains following in vivo recombination of an injected unrearranged kappa gene. The exogenous...
Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation.
Brûlet, P, Babinet, C, Kemler, R, Jacob, F
Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm...
Morello, D, Fitzgerald, M J, Babinet, C, Fausto, N
We investigated the mechanisms of regulation of c-myc, c-fos, and c-jun at the early stages of liver regeneration in mice. We show that the transient increase in steady-state levels of c-myc mRNA at...
Altered expression of heat shock proteins in embryonal carcinoma and mouse early embryonic cells.
Morange, M, Diu, A, Bensaude, O, Babinet, C
In a previous paper, we have shown that in the absence of stress, mouse embryonal carcinoma cells, like mouse early embryo multipotent cells, synthesize high levels of 89- and 70-kilodalton heat...
Identification of a paternal developmental effect on the cytoplasm of one-cell-stage mouse embryos.
Matings of female DDK mice with males of the BALB/c strain are sterile, whereas reciprocal crosses are normally fertile. We used nuclear transplantation between the hybrid eggs of these two strains...
Expression of the cytokeratin endo A gene during early mouse embryogenesis.
Duprey, P, Morello, D, Vasseur, M, Babinet, C, Condamine, H, Brûlet, P, ...
Expression of cytokeratin endo A has been analyzed during mouse blastocyst formation and embryonal carcinoma cell differentiation. To study the regulation of endo A expression, nuclease S1 mapping...
Embryonal carcinoma antigen and the T/t locus of the mouse.
Kemler, R, Babinet, C, Condamine, H, Gachelin, G, Guenet, J L, Jacob, F
The presence of the F9 antigen and of four other antigens related to the T/t locus of the mouse was investigated by immunofluorescence on preimplantation embryos. In morulae heterozygous for any of...
Surface antigen in early differentiation.
Kemler, R, Babinet, C, Eisen, H, Jacob, F
Addition of Fab fragments from rabbit antiserum to surface antigen F9 to 2-cell stage mouse embryos in culture does not alter cleavage; however, the addition prevents culture does not alter cleavage;...
Klarsfeld, A, Bessereau, J L, Salmon, A M, Triller, A, Babinet, C, Changeux, J P
We have obtained transgenic mice expressing nuclearly targeted beta-galactosidase (nls-beta-gal) under the control of a chicken acetylcholine receptor alpha-subunit promoter. The expression of the...
Terzi, F, Henrion, D, Colucci-Guyon, E, Federici, P, Babinet, C, Levy, B I, ...
Modulation of vascular tone by chemical and mechanical stimuli is a crucial adaptive phenomenon which involves cytoskeleton elements. Disruption, by homologous recombination, of the gene encoding...
Impaired flow-induced dilation in mesenteric resistance arteries from mice lacking vimentin.
Henrion, D, Terzi, F, Matrougui, K, Duriez, M, Boulanger, C M, Colucci-Guyon, E, ...
The intermediate filament vimentin might play a key role in vascular resistance to mechanical stress. We investigated the responses to pressure (tensile stress) and flow (shear stress) of mesenteric...
Tronik, D, Dreyfus, M, Babinet, C, Rougeon, F
The Ren-2 gene encoding the mouse submaxillary gland (SMG) renin was microinjected into the pronuclei of fertilized eggs from mice carrying only the Ren-1 gene. In addition to the whole transcription...
Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice.
Morello, D, Moore, G, Salmon, A M, Yaniv, M, Babinet, C
Transgenic mice carrying the H-2K/human growth hormone (hGH) fusion gene were produced by microinjecting into the pronucleus of fertilized eggs DNA molecules containing 2 kb of the 5' flanking...
Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).
Reyes, J C, Barra, J, Muchardt, C, Camus, A, Babinet, C, Yaniv, M
The mammalian SWI-SNF complex is an evolutionarily conserved, multi-subunit machine, involved in chromatin remodelling during transcriptional activation. Within this complex, the BRM (SNF2alpha) and...
BALB/c alleles at modifier loci increase the severity of the maternal effect of the "DDK syndrome".
Le Bras, S, Cohen-Tannoudji, M, Kress, C, Vandormael-Pournin, S, Babinet, C, Baldacci, P
The Om locus was first described in the DDK inbred mouse strain: DDK mice carry a mutation at Om resulting in a parental effect lethality of F(1) embryos. When DDK females are mated with males of...
Mesbah, K., Camus, A., Babinet, C., Barra, J.
Translocon-associated protein complex (TRAP) is thought to be required for efficient protein-specific translocation across the endoplasmic reticulum membrane. We created a mutation in the Trapα gene...
Terzi, F., Maunoury, R., Colucci-Guyon, E., Babinet, C., Federici, P., Briand, P., ...
Proliferation and dedifferentiation of tubular cells are the hallmark of early regeneration after renal ischemic injury. Vimentin, a class III intermediate filament expressed only in mesenchymal...