Interaction of nanoparticles with the pulmonary surfactant system (2009)
Nano-sized particles (NSPs) have a diameter of less than 100nm. When inhaled, they preferentially deposit in the deeper lung, where pulmonary surfactant covers the thin aqueous lining layer. Thus,...
Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models (2009)
Nassimi, M., Schleh, C., Hussein, R., Lübbers, K., Pohlmann, G., ...
The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) for human lung as a suitable drug delivery system (DDS). Therefore we used a human alveolar...
Schleh, C., Muhlfeld, C., Pulskamp, K., Schmiedl, S., Nassimi, M., Lauenstein, H.D., ...
Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of...
Schleh, C., Muhlfeld, C., Pulskamp, K., Schmiedl, S., Nassimi, M., Lauenstein, H.D., ...
Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of...
Die Interaktion zwischen pulmonalem Surfactant und inhalierbaren Partikeln (2009)
Pulmonary surfactant covers the alveoli and reduces surface tension at the air liquid interface, thus maintaining lung function and preventing alveolar collapse. Furthermore, specific surfactant...
Effect of nanosized particles on pulmonary surfactant function (2007)
Schleh, C., Krug, N., Erpenbeck, V.J., Hohlfeld, J.M.
After inhalation, nanoparticles reach the deeper airways and get into contact with the pulmonary surfactant layer, whose main function is to lower surface tension in the alveoli. The aim of our study...
Nanoparticulate vanadium oxide potentiated vanadium toxicity in human lung cells. (2007)
Wörle-Knirsch, J.M., Kern, K., Schleh, C., Adelhelm, C., Feldmann, C., Krug, H.F.
Environmental Science and Technology, 41(2007) S.331-36
Lipidperoxidation als Endpunkt toxischer Partikelwirkung. (2005)
Diplomarbeit, Universität Karlsruhe 2005