Nef, H. M., Mollmann, H., Troidl, C., Kostin, S., Bottger, T., Voss, S., ...
Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction, but its specific pathomechanism remains unknown. Thus, we performed a systematic expression profiling of genes...
Negative inotropic effect of rapamycin on isolated human cardiomyocytes (2008)
Mollmann, H., Nef, H.M., Kahlert, P., Kostin, S., Mollmann, S., Weber, M., ...
Rapamycin is an increasingly important immunosuppressive drug and reduces restenosis after coronary stenting, but its effects on cardiac contractility are largely unknown. We investigated the acute...
Nef, H.M., Mollmann, H., Troidl, C., Kostin, S., Bottger, T., Voss, S., ...
Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction, but its specific pathomechanism remains unknown. Thus, we performed a systematic expression profiling of genes...
Impact of spontaneous reperfusion in diabetics with acute myocardial infarction (2007)
Bainey, K. R, Fu, Y, Granger, C. B, Hamm, C. W, Holmes, D. R, O'Neill, W. W, ...
Nef, H. M., Mollmann, H., Kostin, S., Troidl, C., Voss, S., Weber, M., ...
AIMS: To gain more insight into the phenomenon of Tako-Tsubo cardiomyopathy (TTC), the purpose of the present study was to investigate the myocardial structure in the acute phase of TTC and after...
Temporary third-degree atrioventricular block in a case of apical ballooning syndrome (2006)
Nef, H. M., Mollmann, H., Sperzel, J., Weber, M., Bruck, H., Hamm, C. W., ...
Apical ballooning is characterized by severe but reversible contractile dysfunction. The causative factor and the pathomechanism remain unknown. Several arrhythmias are reported to occur in...
Bone marrow-derived cells contribute to infarct remodelling (2006)
Mollmann, H., Nef, H. M., Kostin, S., Von Kalle, C., Pilz, I., Weber, M., ...
OBJECTIVE: The paradigm that cardiac myocytes are non-proliferating and terminally differentiated cells has recently been challenged by several studies reporting the ability of bone marrow-derived...
Nef, H. M., Mollmann, H., Vogt, A., Weber, M., Deetjen, A., Dill, T., ...
A new cardiac syndrome with transient left ventricular dysfunction has been recently reported and is referred to as Tako-Tsubo cardiomyopathy, which is characterized by a transient akinesia of the...
Acute Coronary Syndrome with and without ST Elevation. (2006)
Mollmann, H., Elsasser, A., Nef, H. M., Weber, M., Hamm, C. W.
Coronary artery disease accounts for most deaths in western communities. The acute coronary syndrome subsidizes ST elevation myocardial infarction, non-ST elevation myocardial infarction, and...
How to revascularize patients with diabetes mellitus-: Bypass or stents and drugs? (2006)
Elsasser, A., Mollmann, H., Nef, H. M., Hamm, C. W.
The diabetic patient is at high risk for coronary artery disease. Incidence as well as severity of the disease is highly increased in comparison to non-diabetic patients. The revascularization of the...
Tako-Tsubo cardiomyopathy -a novel cardiac entity? (2006)
Nef, H. M., Mollmann, H., Hamm, C. W., Elsasser, A.
In recent years, a new cardiac syndrome with transient left ventricular dysfunction has been widely reported in Japan. This new entity has been referred to as "tako-tsubo cardiomyopathy" or "apical...
Prognostic value of placental growth factor in patients with acute chest pain (2004)
Heeschen, C., Dimmeler, S., Fichtlcherer, S., Hamm, C.W., Berger, J., Simoons, M.L., ...
CONTEXT: Experimental data suggest that placental growth factor (PlGF), a member of the vascular endothelial growth factor family, acts as a primary inflammatory instigator of atherosclerotic plaque...
Soluble CD40 ligand in acute coronary syndromes (2003)
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., ...
BACKGROUND: CD40 ligand is expressed on platelets and released from them on activation. We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the...
Prognostic significance growth factor serum levels in patients with acute coronary syndromes (2003)
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., Simoons, M.L.
BACKGROUND: In patients with acute coronary syndromes, compensatory processes are initiated, including angiogenesis and endothelial regeneration of ruptured or eroded plaques. Angiogenic growth...
Soluble CD40 ligand in acute coronary syndromes (2003)
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., ...
BACKGROUND: CD40 ligand is expressed on platelets and released from them on activation. We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the...
Lenderink, T., Boersma, E., Heeschen, C., Vahanian, A., Boer, M.J. De, Umans, V., ...
AIMS: Treatment with the glycoprotein IIb/IIIa receptor antagonist abciximab before and during coronary intervention in refractory unstable angina improves early outcome. We collected 4-year...
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., Simoons, M.L.
BACKGROUND: In patients with acute coronary syndromes, compensatory processes are initiated, including angiogenesis and endothelial regeneration of ruptured or eroded plaques. Angiogenic growth...
Lenderink, T, Boersma, E, Heeschen, C, Vahanian, A, Umans, V, ...
Aims Treatment with the glycoprotein IIb/IIIa receptor antagonist abciximab before and during coronary intervention in refractory unstable angina improves early outcome. We collected 4-year follow-up...
548 Contractile response and mitral regurgitation after withdrawl of biventricular pacing (2003)
Brandt, R. R., Reiner, R., Sperzel, J., Pitschner, H. F., Hamm, C. W.
Roffi, M., Chew, D.P., Mukherjee, D., Bhatt, D.L., White, J.A., Moliterno, D.J., ...
Aims To assess the efficacy of platelet glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndromes primarily medically managed. Methods and Results We performed a meta-analysis of the...
Piek, J.J., Mudra, H., Hamm, C.W., Schofer, J., Bertrand, M., ...
Heeschen, C., Hamm, C.W., Bruemmer, J., Simoons, M.L.
OBJECTIVES: We evaluated C-reactive protein (CRP) and troponin T (TnT) for predicting six-month cardiac risk in patients with unstable angina. BACKGROUND: Troponin T is predictive of cardiac risk in...
Heeschen, C., Goldmann, B.U., Terres, W., Hamm, C.W.
Aims Elevation of troponin T in patients with unstable angina is predictive of adverse outcomes. Since no advanced therapeutic concept for such high-risk patients has been established, we...
Dill, T, Dietz, U, Hamm, C.W, Küchler, R, Haude, M, ...
Aims Rotablation is a widely used technique for the treatment of complex coronary artery lesions but is so far only poorly supported by controlled studies. The Comparison of Balloon-Angioplasty...
Hamm, C.W., Heeschen, C., Goldmann, B., Vahanian, A., Adgey, J., Macaya, M., ...
BACKGROUND: In patients with refractory unstable angina, the platelet glycoprotein IIb/IIIa-receptor antibody abciximab reduces the incidence of cardiac events before and during coronary angioplasty....
Heeschen, C., Hamm, C.W., Simoons, M.L.
BACKGROUND: The CAPTURE (C7E3 fab AntiPlatelet Therapy in Unstable REfactory angina) trial enrolled patients with refractory unstable angina and documented a therapeutic benefit for abciximab, a...
Hamm, C.W., Heeschen, C., Goldmann, B., Vahanian, A., Adgey, J., Miguel, C.M., ...
BACKGROUND: In patients with refractory unstable angina, the platelet glycoprotein IIb/IIIa-receptor antibody abciximab reduces the incidence of cardiac events before and during coronary angioplasty....
Heeschen, C., Hamm, C.W., Simoons, M.L.
BACKGROUND: The CAPTURE (C7E3 fab AntiPlatelet Therapy in Unstable REfactory angina) trial enrolled patients with refractory unstable angina and documented a therapeutic benefit for abciximab, a...
Coronary angioplasty in octogenarians. Quality of life and costs (1999)
Kähler, J., Lütke, M., Weckmüller, J., Köster, R., Meinertz, T., Hamm, C.W.
Background Improvement in quality of life is the major motivation for angioplasty in very elderly patients. The alleviation of symptoms with this method is therefore of particular interest. However,...
Maseri, A, Armstrong, P W, Califf, R M, Gibler, W B, Hamm, C W, ...
Platelet glycoprotein (GP) IIb/IIIa blockade has the potential to advance treatment of acute coronary syndromes, both as a primary pharmacologic approach and an adjunct to interventional treatment...
Maseri, A, Armstrong, P W, Califf, R M, Gibler, W B, Hamm, C W, ...
Platelet glycoprotein (GP) IIb/IIIa blockade has the potential to advance treatment of acute coronary syndromes, both as a primary pharmacologic approach and an adjunct to interventional treatment...
Coronary angiography with synchrotron radiation (1994)
Dix, W R, Graeff, W, Illing, G, Menk, R H, Reime, B, Schwildwächter, L, ...
Peptide sequencing program (1986)
Hamm, C. W., Wilson, W. E., Harvan, D. J.
A computer program has been devised to automate rationalization of peptide fragmentation patterns. The program systematically generates all possible linear amino acid sequences which might be...
Opie, L. H., Thandroyen, F. T., Hamm, C. W., Muller, C. A., Lloyd, E. A., Gordon, D.
To investigate and to compare the protective action of verapamil, nifedipine and diltiazem on the acutely infarcting myocardium, we studied effects on cellular damage and mechanical function in the...
KUPPER, W., SCHÜTT, M., HAMM, C. W., KUCK, K. H., HANRATH, P., BLEIFELD, W.
Prenalterol, a β1 selective agonist, exerts a positive inotropic action in animal studies as well as in human volunteers and is effective when administered orally. To assess its immediate...
Kupper, W, Hamm, C W, Bleifeld, W
1 The study was designed to elucidate further the mechanism by which beta-adrenoceptor antagonism with pindolol relieves the symptoms of angina pectoris in patients with coronary heart disease. 2...