Can Zhong

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex (2008)

Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.

It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid...

Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.

Zhong, Can, Chen, Chin, Kilberg, Michael S

Transcription from the human asparagine synthetase (A.S.) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation....

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, Stela S., Thiaville, Michelle M., Pan, Yuan-Xiang, Zhong, Can, Kilberg, Michael S.

The neutral amino acid transport activity, System A, is enhanced by amino acid limitation of mammalian cells. Of the three gene products that encode System A activity, the one that exhibits this...

Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.

Zhong, Can, Chen, Chin, Kilberg, Michael S

Transcription from the human asparagine synthetase (A.S.) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation....

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, Stela S., Thiaville, Michelle M., Pan, Yuan-Xiang, Zhong, Can, Kilberg, Michael S.

The neutral amino acid transport activity, System A, is enhanced by amino acid limitation of mammalian cells. Of the three gene products that encode System A activity, the one that exhibits this...

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.

It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid...

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells*

Thiaville, Michelle M., Pan, Yuan-Xiang, Gjymishka, Altin, Zhong, Can, Kaufman, Randal J., Kilberg, Michael S.

The mammalian amino acid response (AAR) pathway is up-regulated by protein or amino acid depletion. This pathway involves detection of uncharged tRNA by the GCN2 kinase, phosphorylation of the...