Christian Mawrin

EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy (2008)

Holtkamp, Nikola, Malzer, Elke, Zietsch, Jan, Okuducu, Ali Fuat, Mucha, Jana, Mawrin, Christian, ...

Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas with poor prognosis and limited treatment options. Evidence for a role of epidermal growth factor receptor (EGFR) and receptor tyrosine...

Evidence for a wide extra-astrocytic distribution of S100B in human brain (2007)

Steiner, Johann, Bernstein, Hans-Gert, Bielau, Hendrik, Berndt, Annika, Brisch, Ralf, Mawrin, Christian, ...

Abstract Background S100B is considered an astrocytic in-situ marker and protein levels in cerebrospinal fluid (CSF) or serum are often used as biomarker for astrocytic damage or dysfunction....

Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity (2006)

Holtkamp, Nikola, Okuducu, Ali Fuat, Mucha, Jana, Afanasieva, Anastasia, Hartmann, Christian, Atallah, Isis, ...

Platelet-derived growth factor receptor alpha (PDGFRα) and c-Kit are receptor tyrosine kinases. Both are targets of the tyrosine kinase inhibitor imatinib mesylate which is approved for treatment of...

The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells (2006)

Eljaschewitsch, Eva, Witting, Anke, Mawrin, Christian, Lee, Thomas, Schmidt, Peter, Wolf, Susanne, ...

The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells (2006)

Eljaschewitsch, Eva, Witting, Anke, Mawrin, Christian, Lee, Thomas, Schmidt, Peter, Wolf, Susanne, ...

PDGFRA and KIT dysregulation and mutation in malignant peripheral nerve sheath tumours (2005)

Holtkamp, Nikola, Okuducu, Ali Fuat, Mucha, Jana, Afanasieva, Anastasia, Hartmann, Christian, Atallah, Isis, ...

Platelet-derived growth factor receptor alpha (PDGFRα) and c-Kit are receptor tyrosine kinases. Both are targets of the tyrosine kinase inhibitor imatinib mesylate which is approved for treatment of...

Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis (2003)

Machner, Andreas, Baier, Anja, Wille, Aline, Drynda, Susanne, Pap, Géza, Drynda, Andreas, ...

Abstract The aim of the present study was to investigate the expression of Fas in periarticular tenocytes of patients with osteoarthritis (OA) and to study their susceptibility to Fas ligand-mediated...

Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis

Machner, Andreas, Baier, Anja, Wille, Aline, Drynda, Susanne, Pap, Géza, Drynda, Andreas, ...

The aim of the present study was to investigate the expression of Fas in periarticular tenocytes of patients with osteoarthritis (OA) and to study their susceptibility to Fas ligand-mediated...

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

Juang, Yuang-Taung, Wang, Ying, Solomou, Elena E., Li, Yansong, Mawrin, Christian, Tenbrock, Klaus, ...

Systemic lupus erythematosus (SLE) T cells express high levels of cAMP response element modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 gene. This study...

Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis

Machner, Andreas, Baier, Anja, Wille, Aline, Drynda, Susanne, Pap, Géza, Drynda, Andreas, ...

The aim of the present study was to investigate the expression of Fas in periarticular tenocytes of patients with osteoarthritis (OA) and to study their susceptibility to Fas ligand-mediated...

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

Juang, Yuang-Taung, Wang, Ying, Solomou, Elena E., Li, Yansong, Mawrin, Christian, Tenbrock, Klaus, ...

Systemic lupus erythematosus (SLE) T cells express high levels of cAMP response element modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 gene. This study...

Evidence for a wide extra-astrocytic distribution of S100B in human brain

Steiner, Johann, Bernstein, Hans-Gert, Bielau, Hendrik, Berndt, Annika, Brisch, Ralf, Mawrin, Christian, ...

Retention of the Arginine Allele in Codon 72 of the p53 Gene Correlates with Poor Apoptosis in Head and Neck Cancer

Schneider-Stock, Regine, Mawrin, Christian, Motsch, Christiane, Boltze, Carsten, Peters, Brigitte, Hartig, Roland, ...

The allele constitution at codon 72 of the p53 gene (CGC-arginine or CCC-proline) plays a major role in inducing apoptosis in p53 mutant cells. To verify this, we determined GC-status, p53-mutations,...

MMP-13 and p53 in the Progression of Malignant Peripheral Nerve Sheath Tumors1

Holtkamp, Nikola, Atallah, Isis, Okuducu, Ali-Fuat, Mucha, Jana, Hartmann, Christian, Mautner, Victor-F, ...

Malignant peripheral nerve sheath tumors (MPNST) are sarcomas with poor prognosis and limited treatment options. Factors contributing to tumor progression are largely unknown. We therefore examined...

EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy

Holtkamp, Nikola, Malzer, Elke, Zietsch, Jan, Okuducu, Ali Fuat, Mucha, Jana, Mawrin, Christian, ...

Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas with poor prognosis and limited treatment options. Evidence for a role of epidermal growth factor receptor (EGFR) and receptor tyrosine...