Steinhoff, Christine, Paulsen, Martina, Kielbasa, Szymon, Walter, Jörn, Vingron, Martin
Abstract Background In mammals, imprinted genes are regulated by an epigenetic mechanism that results in parental origin-specific expression. Though allele-specific regulation of imprinted genes has...
147. Gaussian Mixture Density Estimation applied to Microarray Data (2008)
Christine Steinhoff, Tobias Müller, Ulrike Nuber, Martin Vingron
Microarray experiments can be used to determine gene expression profiles of specific cell types. In this way, genes of a given cell type might be categorized into active or not. Typically one would...
Er Schliep, Ivan G. Costa, Christine Steinhoff, Er Schönhuth
Abstract—Measuring gene expression over time can provide important insights into basic cellular processes. Identifying groups of genes with similar expression time-courses is a crucial first step...
Ein zentrales Problem der Tumorgentherapie ist die Selektivität. Eine Möglichkeit, Tumorzellen selektiv zu zerstören, besteht in der Expression eines toxischen Gens mit einem tumorspezifischen...
Methylation of Endogenous Human Retroelements in Health and Disease (2006)
Schulz, W. A., Steinhoff, Christine, Florl, A. R.
Retroelements constitute approximately 45% of the human genome. Long interspersed nuclear element (LINE) autonomous retrotransposons are predominantly represented by LINE-1, nonautonomous small...
Review: Normalization and Quantification of Differential Expression (2006)
Steinhoff, Christine, Vingron, Martin
Array-based gene expression studies frequently serve to identify genes that are expressed differently under two or more conditions. The actual analysis of the data, however, may be hampered by a...
Normalization and quantification of differential expression in gene expression microarrays (2006)
Steinhoff, Christine, Vingron, Martin
Array-based gene expression studies frequently serve to identify genes that are expressed differently under two or more conditions. The actual analysis of the data, however, may be hampered by a...
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome (2005)
Nuber, Ulrike A., Kriaucionis, Skirmantas, Roloff, Tim C., Guy, Jacky, Selfridge, Jim, Steinhoff, Christine, ...
Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently unknown. Mice...
Oostendorp, Robert A.J., Robin, Catherine, Steinhoff, Christine, Marz, Stefanie, Bräuer, Rosalinde, Nuber, Ulrike A., ...
We recently established that two midgestation-derived stromal clones—UG26-1B6, urogenital ridge–derived, and EL08-1D2, embryonic liver–derived—support the maintenance of murine adult bone...
Schliep, Alexander, Costa, Ivan G., Steinhoff, Christine, Schonhuth, Alexander
Measuring gene expression over time can provide important insights into basic cellular processes. Identifying groups of genes with similar expression time-courses is a crucial first step in the...
Oostendorp, Robert A.J., Robin, Catherine, Steinhoff, Christine, Marz, Stefanie, Braeuer, Rosalinde, Nuber, Ulrike A., ...
We recently established that two midgestation-derived stromal clones—UG26-1B6, urogenital ridge–derived, and EL08-1D2, embryonic liver–derived—support the maintenance of murine adult bone...
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome (2005)
Nuber, Ulrike A., Kriaucionis, Skirmantas, Roloff, Tim C., Guy, Jacky, Selfridge, Jim, Steinhoff, Christine, ...
Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently unknown. Mice...
Oostendorp, Robert A.J., Robin, Catherine, Steinhoff, Christine, Marz, Stefanie, Braeuer, Rosalinde, Nuber, Ulrike A., ...
We recently established that two midgestation-derived stromal clones—UG26-1B6, urogenital ridge–derived, and EL08-1D2, embryonic liver–derived—support the maintenance of murine adult bone...
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome (2005)
Nuber, Ulrike A., Kriaucionis, Skirmantas, Roloff, Tim C., Guy, Jacky, Selfridge, Jim, Steinhoff, Christine, ...
Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently unknown. Mice...
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome (2005)
Nuber, Ulrike A., Kriaucionis, Skirmantas, Roloff, Tim C., Guy, Jacky, Selfridge, Jim, Steinhoff, Christine, ...
Rett syndrome (RTT) is a severe form of mental retardation in girls, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently...
Gene expression changes in the course of neural progenitor cell differentiation (2004)
Gurok,Ulf, Steinhoff,Christine, Lipkowitz,Bettina, Ropers,Hans-Hilger, Scharff,Constance, Nuber,Ulrike A.
The molecular changes underlying neural progenitor differentiation are essentially unknown. We applied cDNA microarrays with 13,627 clones to measure dynamic gene expression changes during the in...
Gene expression changes in the course of neural progenitor cell differentiation (2004)
Gurok,Ulf, Steinhoff,Christine, Lipkowitz,Bettina, Ropers,Hans-Hilger, Scharff,Constance, Nuber,Ulrike A.
The molecular changes underlying neural progenitor differentiation are essentially unknown. We applied cDNA microarrays with 13,627 clones to measure dynamic gene expression changes during the in...
Singh,Umashankar, Fohn,Laurel E., Wakayama,Teruhiko, Ohgane,Jun, Steinhoff,Christine, Lipkowitz,Bettina, ...
To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia...
Singh,Umashankar, Fohn,Laurel E., Wakayama,Teruhiko, Ohgane,Jun, Steinhoff,Christine, Lipkowitz,Bettina, ...
To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia...
Robust inference of groups in gene expression time-courses using mixtures of HMMs (2004)
Schliep,Alexander, Steinhoff,Christine, Schoenhuth,Alexander
Motivation: Genetic regulation of cellular processes is frequently investigated using large-scale gene expression experiments to observe changes in expression over time. This temporal data poses a...
Transcriptional regulation of the human LINE-1 retrotransposon L1.2B (2004)
Steinhoff,Christine, Schulz,W. A.
Although LINE-1 (L1) sequences constitute the most important family of retrotransposons in the human genome, their transcriptional regulation is poorly understood. Specifically, their unusual...
Transcriptional regulation of the human LINE-1 retrotransposon L1.2B (2004)
Steinhoff, Christine, Schulz, W. A.
Although LINE-1 (L1) sequences constitute the most important family of retrotransposons in the human genome, their transcriptional regulation is poorly understood. Specifically, their unusual...
Gene expression changes in the course of neural progenitor cell differentiation (2004)
Gurok, Ulf, Steinhoff, Christine, Lipkowitz, Bettina, Ropers, Hans-Hilger, Scharff, Constance, Nuber, Ulrike A.
The molecular changes underlying neural progenitor differentiation are essentially unknown. We applied cDNA microarrays with 13,627 clones to measure dynamic gene expression changes during the in...
Singh, Umashankar, Fohn, Laurel E., Wakayama, Teruhiko, Ohgane, Jun, Steinhoff, Christine, Lipkowitz, Bettina, ...
To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia...
Robust inference of groups in gene expression time-courses using mixtures of HMMs (2004)
Schliep, Alexander, Steinhoff, Christine, Schoenhuth, Alexander
Motivation: Genetic regulation of cellular processes is frequently investigated using large-scale gene expression experiments to observe changes in expression over time. This temporal data poses a...
Singh, Umashankar, Fohn, Laurel E., Wakayama, Teruhiko, Ohgane, Jun, Steinhoff, Christine, Lipkowitz, Bettina, ...
To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia...
Gene expression changes in the course of neural progenitor cell differentiation (2004)
Gurok, Ulf, Steinhoff, Christine, Lipkowitz, Bettina, Ropers, Hans-Hilger, Scharff, Constance, Nuber, Ulrike A.
The molecular changes underlying neural progenitor differentiation are essentially unknown. We applied cDNA microarrays with 13,627 clones to measure dynamic gene expression changes during the in...
Robust inference of groups in gene expression time-courses using mixtures of HMMs (2004)
Schliep, Alexander, Steinhoff, Christine, Schönhuth, Alexander
Motivation: Genetic regulation of cellular processes is frequently investigated using large-scale gene expression experiments to observe changes in expression over time. This temporal data poses a...
Grimm,Marc-Oliver, Steinhoff,Christine, Simon,Xenia, Spiegelhalder,Philipp, Ackermann,Rolf, Vogeli,Thomas Alexander
Purpose: We determined the long-term outcome in patients with superficial bladder cancer (Ta and T1) undergoing routine second transurethral bladder tumor resection (ReTURB) in regard to recurrence...
Using hidden Markov models to analyze gene expression time course data (2003)
Schliep,Alexander, Schönhuth,Alexander, Steinhoff,Christine
Motivation: Cellular processes cause changes over time. Observing and measuring those changes over time allows insights into the how and why of regulation. The experimental platform for doing the...
Wieczorek,Georg, Steinhoff,Christine, Schulz,Ralph, Scheller,Marina, Vingron,Martin, Ropers,Hans-Hilger, ...
Bone marrow stromal cells (BMSC) have gained increased attention because of their multipotency and adult stem cell character. They have been shown to differentiate into other cell types of the...
Gaussian mixture density estimation applied to microarray data (2003)
Steinhoff,Christine, Müller,Tobias, Nuber,Ulrike A., Vingron,Martin
Several publications have focused on fitting a specific distribution to overall microarray data. Due to a number of biological features the distribution of overall spot intensities can take various...
Wieczorek, Georg, Steinhoff, Christine, Schulz, Ralph, Scheller, Marina, Vingron, Martin, Ropers, Hans-Hilger, ...
Bone marrow stromal cells (BMSC) have gained increased attention because of their multipotency and adult stem cell character. They have been shown to differentiate into other cell types of the...
Grimm, Marc-Oliver, Steinhoff, Christine, Simon, Xenia, Spiegelhalder, Philipp, Ackermann, Rolf, Vogeli, Thomas Alexander
Purpose: We determined the long-term outcome in patients with superficial bladder cancer (Ta and T1) undergoing routine second transurethral bladder tumor resection (ReTURB) in regard to recurrence...
Using hidden Markov models to analyze gene expression time course data (2003)
Schliep, Alexander, Schönhuth, Alexander, Steinhoff, Christine
Motivation: Cellular processes cause changes over time. Observing and measuring those changes over time allows insights into the how and why of regulation. The experimental platform for doing the...
Gaussian mixture density estimation applied to microarray data (2003)
Steinhoff, Christine, Müller, Tobias, Nuber, Ulrike A., Vingron, Martin
Several publications have focused on fitting a specific distribution to overall microarray data. Due to a number of biological features the distribution of overall spot intensities can take various...
Using hidden Markov models to analyze gene expression time course data (2003)
Alexander Schliep, Alexander Schönhuth, Christine Steinhoff
Vol. 19 Suppl. 1 2003, pages i255–i263
Using hidden Markov models to analyze gene expression time course data (2003)
Schliep, Alexander, Schönhuth, Alexander, Steinhoff, Christine
Motivation: Cellular processes cause changes over time. Observing and measuring those changes over time allows insights into the how and why of regulation. The experimental platform for doing the...
Steinhoff,Christine, Prior,Andrea, Reichmann,Gabi, Seifert,Hans-Helge, Schulz,Wolfgang A.
Abstract. Inactivation of P53 and RB functions are crucial changes in bladder cancer (TCC). High-level re-expression of P53 elicits apoptosis in TCC cell lines, but also - as shown here - in normal...
Steinhoff, Christine, Prior, Andrea, Reichmann, Gabi, Seifert, Hans-Helge, Schulz, Wolfgang A.
Abstract. Inactivation of P53 and RB functions are crucial changes in bladder cancer (TCC). High-level re-expression of P53 elicits apoptosis in TCC cell lines, but also - as shown here - in normal...
Hamburg, Med. F., Diss. v. 26. Febr. 1966.
Thesis (doctoral)--Universität Hamburg, 1966.
Genome-wide distribution and localization of putative functional human LINE-1 retrotransposons
Steinhoff,Christine, Schulz,Wolfgang A.
Three human LINE families comprise 20.4% of the human genome. LINE-1 sequences with 55 subfamilies account for 16.9% and contain all retrotransposons for which autonomous retrotransposition has been...
Genome-wide distribution and localization of putative functional human LINE-1 retrotransposons
Steinhoff, Christine, Schulz, Wolfgang A.
Three human LINE families comprise 20.4% of the human genome. LINE-1 sequences with 55 subfamilies account for 16.9% and contain all retrotransposons for which autonomous retrotransposition has been...