Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice (2009)
Hao, Jing, Liu, Ba, Yang, Chung S, Chen, Xiaoxin
Abstract Background Esophago-gastroduodenal anastomosis with rats mimics the development of human Barrett's esophagus and esophageal adenocarcinoma by introducing mixed reflux of gastric and duodenal...
Ju, Jihyeung, Nolan, Bonnie, Cheh, Michelle, Bose, Mousumi, Lin, Yong, Wagner, George C, ...
Abstract Background Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study...
Chen, Xiaoxin, Qin, Rong, Liu, Ba, Ma, Yan, Su, Yinghao, Yang, Chung S, ...
Abstract Background In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical carcinogen treatment leads to gastroesophageal reflux disease, multilayered epithelium (MLE, a...
Xiao, Hang, Hao, Xingpei, Simi, Barbara, Ju, Jihyeung, Jiang, Heyuan, Reddy, Bandaru S., ...
Green tea and its constituents have shown cancer-preventive activities in many animal models. In order to prepare for a human trial on the inhibition of colon carcinogenesis, we conducted a study...
Lambert, Joshua D., Kwon, Seok-Joo, Ju, Jihyeung, Bose, Mousumi, Lee, Mao-Jung, Hong, Jungil, ...
The green tea (Camellia sinensis) catechin, (-)-epigallocatechin-3-gallate (EGCG), has shown cancer-preventive activity in animal models. Previously, we have reported the bioavailability of EGCG in...
Advance and Briefs Mechanisms of Inactivation of p14 ARF, p15 INK4b, and p16 INK4a Genes (2007)
Eric Poe Xing, Yan Nie, Yunlong Song, Guang-yu Yang, Yuyang Christine Cai, Li-dong Wang, ...
The 9p21 gene cluster, harboring growth suppressive genes p14 ARF, p15 INK4b, and p16 INK4a, is one of the major aberration hotspots in human cancers. It was shown that p14 ARF and p16 INK4a play...
Carcinogenesis Vol.20 No.1 Pp.77--84, 1999 (2007)
Aberrant Methylation Of, Eric Poe Xing, Yan Nie, Li-dong Wang, Guang-yu Yang, Chung S. Yang
nuous homozygous deletion spanning both p15 . Six cases were exclusively deleted at p16 and 17 exclusively deleted at p15 . LOH at D9S942 and D9S171 was also found to be mutually exclusive. Our...
Liu, Tong, Zhang, Xinyan, So, Chi-Kwong, Wang, Su, Wang, Peng, Yan, Liying, ...
Caudal-related homeobox 2 (Cdx2) has been suggested as an early marker of Barrett's esophagus (BE), which is the premalignant lesion of esophageal adenocarcinoma (EAC). However, the mechanism of...
Sun, Zheng, Sood, Sandeep, Li, Ning, Ramji, Divya, Yang, Peiying, Newman, Robert A., ...
Previous studies have shown that aberrant arachidonic acid (AA) metabolism, especially cyclooxygenase-2 (Cox-2) and 5-lipoxygenase (5-Lox) pathways, are activated during oral carcinogenesis, and can...
Liu, Tong, Zhang, Xinyan, So, Chi-Kwong, Wang, Su, Wang, Peng, Yan, Liying, ...
Caudal-related homeobox 2 (Cdx2) has been suggested as an early marker of Barrett's esophagus (BE), which is the premalignant lesion of esophageal adenocarcinoma (EAC). However, the mechanism of...
Sun, Zheng, Sood, Sandeep, Li, Ning, Ramji, Divya, Yang, Peiying, Newman, Robert A., ...
Previous studies have shown that aberrant arachidonic acid (AA) metabolism, especially cyclooxygenase-2 (Cox-2) and 5-lipoxygenase (5-Lox) pathways, are activated during oral carcinogenesis, and can...
Lu, Yao-Ping, Lou, You-Rong, Liao, Jie, Xie, Jian-Guo, Peng, Qing-Yun, Yang, Chung S., ...
Irradiation of female SKH-1 hairless mice with UVB (30 mJ/cm2) twice a week for 10–20 weeks resulted in the formation of a large number of cellular patches (>8 adjacent cells/patch) that...
Lu, Yao-Ping, Lou, You-Rong, Liao, Jie, Xie, Jian-Guo, Peng, Qing-Yun, Yang, Chung S., ...
Irradiation of female SKH-1 hairless mice with UVB (30 mJ/cm2) twice a week for 10-20 weeks resulted in the formation of a large number of cellular patches (>8 adjacent cells/patch) that are...
Hong, Jungil, Sang, Shengmin, Park, Hye-Jin, Kwon, Seok Joo, Suh, Nanjoo, Huang, Mou-Tuan, ...
Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anti-carcinogenic activities. To study its mechanism of action, we...
Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas (2004)
Fang, Ming Zhu, Liu, Changgong, Song, Yunlong, Yang, Guang-Yu, Nie, Yan, Liao, Jie, ...
Gastrin-releasing peptide (GRP) is known as an autocrine growth factor for a number of gastrointestinal cancers. There is, however, little information on the expression of GRP in the squamous...
Overexpression of gastrin-releasing peptide in human esophageal squamous cell carcinomas (2004)
Fang, Ming Zhu, Liu, Changgong, Song, Yunlong, Yang, Guang-Yu, Nie, Yan, Liao, Jie, ...
Gastrin-releasing peptide (GRP) is known as an autocrine growth factor for a number of gastrointestinal cancers. There is, however, little information on the expression of GRP in the squamous...
Hong, Jungil, Bose, Mousumi, Ju, Jihyeung, Ryu, Jae-Ha, Chen, Xiaoxin, Sang, Shengmin, ...
Aberrant arachidonic acid metabolism is involved in the inflammatory and carcinogenic processes. In this study, we investigated the effects of curcumin, a naturally occurring chemopreventive agent,...
Hong, Jungil, Bose, Mousumi, Ju, Jihyeung, Ryu, Jae-Ha, Chen, Xiaoxin, Sang, Shengmin, ...
Aberrant arachidonic acid metabolism is involved in the inflammatory and carcinogenic processes. In this study, we investigated the effects of curcumin, a naturally occurring chemopreventive agent,...
Chen, Xiaoxin, Li, Ning, Wang, Su, Wu, Nan, Hong, Jungil, Jiao, Xiaolong, ...
Background: Esophageal adenocarcinoma (EAC) is increasing at the most rapid rate of any cancer in the United States. An esophagogastroduodenal anastomosis (EGDA) surgical model in rats mimics human...
Seril, Darren N., Liao, Jie, Yang, Guang-Yu, Yang, Chung S.
The chronic inflammatory bowel disease ulcerative colitis (UC) occurs commonly in the US and other Western countries, but its etiology is unknown. An association between UC and an elevated risk for...
Prospective Study of Serum Vitamin E Levels and Esophageal and Gastric Cancers (2003)
Taylor, Philip R., Qiao, You-Lin, Abnet, Christian C., Dawsey, Sanford M., Yang, Chung S., Gunter, Elaine W., ...
Participants in the General Population Trial, a randomized nutrition intervention trial in Linxian, China, who received a combination of selenium, β-carotene, and vitamin E supplements, had...
Li, Ning, Chen, Xiaoxin, Liao, Jie, Yang, Guangyu, Wang, Su, Josephson, Youssef, ...
Tea is one of the most popular beverages consumed in the world. Curcumin, the major yellow pigment in turmeric, is used widely as a spice and food-coloring agent. In this study, we studied the...
Chen, Xiaoxin, Ding, Yu, Liu, Chang-Gong, Mikhail, Samer, Yang, Chung S.
A rat surgical esophageal adenocarcinoma (EAC) model induced by esophagogastroduodenal anastomosis was recently established in our laboratory. This model mimics mixed reflux of gastric and duodenal...
Nie, Yan, Liao, Jie, Zhao, Xin, Song, Yunlong, Yang, Guang-yu, Wang, Li-Dong, ...
Abnormal hypermethylation of CpG islands associated with tumor suppressor genes can lead to repression of gene expression and contribute significantly to tumorigenesis. Esophageal squamous cell...
Sun, Can-Lan, Yuan, Jian-Min, Lee, Mao-Jung, Yang, Chung S., Gao, Yu-Tang, Ross, Ronald K., ...
Experimental studies have shown that tea and tea polyphenols have anticarcinogenic properties. There have been no prospective investigations examining the relationship between tea polyphenols and...
Seril, Darren N., Liao, Jie, Ho, Kwok-Lam K., Yang, Chung S., Yang, Guang-Yu
Long-term ulcerative colitis (UC) patients are at increased risk for developing colorectal cancer. In order to develop strategies for preventing UC-associated carcinogenesis, we studied the effect of...
The incidence rate of esophageal adenocarcinoma (EAC) has increased sharply in the past 30 years. Many risk factors have been identified and gastroesophageal reflux disease (GERD) is the most...
Nie, Yan, Yang, Guang-yu, Song, Yunlong, Zhao, Xin, So, Chi, Liao, Jie, ...
The three human leukocyte antigen (HLA) class I antigens, HLA-A, HLA-B and HLA-C, play important roles in the elimination of transformed cells by cytotoxic T cells. Frequent loss of expression of...
Cai, Yuyang Christine, Yang, Guang-yu, Nie, Yan, Wang, Li-Dong, Zhao, Xin, Song, Yun-long, ...
p73 is structurally and functionally related to p53 and is possibly a tumor suppressor gene. Using 15 surgically resected frozen esophageal specimens containing both squamous cell carcinomas (ESCC)...
Yang, Guang-Yu, Liao, Jie, Li, Chengchung, Chung, Jee, Yurkow, Edward J., Ho, Chi-Tang, ...
The biological activities of theaflavin (TF), theaflavin gallate (TFG) and theaflavin digallate (TFdiG) from black tea and (–)-epigallocatechin 3-gallate (EGCG) and (–)-epigallocatechin (EGC)...
Chen, Xiaoxin, Mikhail, Samer S., Ding, Yu Wei, Yang, Guang-yu, Bondoc, Floredeliza, Yang, Chung S.
Two well-known antioxidative nutrients, vitamin E and selenium, were used in this study to investigate possible inhibitory action against the formation of esophageal adenocarcinoma (EAC) in rats. In...
Oxidative damage in an esophageal adenocarcinoma model with rats (2000)
Chen, Xiaoxin, Ding, Yu Wei, Yang, Guang-yu, Bondoc, Flordeliza, Lee, Mao-Jun, Yang, Chung S.
Oxidative damage has long been related to carcinogenesis in human cancers and animal cancer models. Recently a rat esophageal adenocarcinoma (EAC) model was established in our laboratory by using...
Eric Poe Xing, Guang-Yu Yang, Li-dong Wang, Stephanie Tao Shi, Chung S. Yang
To understand the alterations of Rb tumor suppressor gene and the relationship between defects in the Rb and p53 pathways in human esophageal carcinogenesis, we examined the loss of heterozygosity...
Shi, Stephanie T., Yang, Guang-Yu, Wang, Li-Dong, Xue, Zhihong, Feng, Bo, Ding, Wei, ...
In order to characterize p53 alterations in esophageal cancer and to study their roles in carcinogenesis, we performed gene mutation and immunohistochemical analysis on 43 surgically resected human...
Chen, Xiaoxin, Yang, Guang-yu, Ding, Wei Yu, Bondoc, Flordeliza, Curtis, Stephen K., Yang, Chung S.
The aim of this study is to establish a good animal model for esophageal adenocarcinoma (EAC) and to test the hypothesis that iron over-nutrition enhances EAC formation. With rats,...
Xing, Eric Poe, Nie, Yan, Wang, Li-Dong, Yang, Guang-Yu, Yang, Chung S.
p16INK4a and p15INK4b genes, which encode two functionally related CDK inhibitors, recently emerged as candidate tumor suppressor genes since they were both localized to 9p21, which frequently...
Hong, Jun-Yan, Wang, Yong-Yu, Flordeliza, Y. Bondoc, Yang, Chung S., Lee, Maojung, Huang, Wei-Qun
Methyl tert-butyl ether (MTBE) is a widely used gasoline oxygenate. Two other ethers, ethyl tert-butyl ether (ETBE) and tert-amyl methyl ether (TAME), are also used in reformulated gasoline....
Shi, Stephanie T., Feng, Bo, Yang, Guang-Yu, Wang, Li-Dong, Yang, Chung S.
Accumulation of p53 protein occurs in human oesophageal precancerous lesions and even in near-normal oesophageal epithelium. In some instances, p53 gene mutations have been detected. In many of the...
Jiao, Ding, Smith, Theresa J., Kim, Sungbin, Yang, Chung S., Desai, Dhimant, Amin, Shantu, ...
The importance of the isothiocyanate group in alkyl isothiocyanate for inhibition of tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis was...
Smith, Theresa J., Guo, Zuyu, Guengerich, F.Peter, Yang, Chung S.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent tobacco-specific nitrosamine in animals and has been suggested to play a role in human tobacco-related cancers. Our previous study...
Wang, Zhi Yuan, Wan, Li-Dong, Lee, Mao-Jung, Ho, Chi-Tang, Huang, Mou-Tuan, Conney, Allan H., ...
In this study, we investigated the effects of green tea and black tea, when given either during or after carcinogen treatment, on esophageal tumorigenesis in male Sprague—Dawley rats. Rats were...
Blot, William J., Li, Jun-Yao, Taylor, Philip R., Guo, Wande, Dawsey, Sanford, Wang, Guo-Qing, ...
Background Epidemiologic evidence indicates that diets high in fruits and vegetables are associated with a reduced risk of several cancers, including cancers of the esophagus and stomach. Vitamins...
Li, Jun-Yao, Taylor, Philip R., Li, Bing, Dawsey, Sanford, Wang, Guo-Qing, Ershow, Abby G., ...
Background A number of vitamins and minerals have been shown to influence carcinogenesis in experimental animals. In humans, epidemiologic evidence suggests that intake of fruits and vegetables may...
Hong, Jun-Yan, Ding, Xinxin, Smith, Theresa J., Minor, J. Coon, Yang, Chung S.
The publishers would like to apologise for mis-printing the last paragraph to the Introduction of die above paper. The corrected paragraph follows: Recently two novel forms of P450 (P450NMa and -NMb)...
Yang, Chung S., Wang, Zhi-Yuan
Tea is one of the most popular beverages consumed worldwide. The relationship between tea consumption and human cancer incidence is an important concern. This topic has been studied in different...
Guo, Zuyu, Smith, Theresa J., Wang, Erjia, Eklind, Karin I., Chung, Fung-Lung, Yang, Chung S.
Many arylalkyl isothiocyanates are potent inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in rats and mice. In the mouse, 4-phenylbutyl isothiocyanate...
Hong, Jun-Yan, Ding, Xinxin, Smith, Theresa J., Coon, Minor J., Yang, Chung S.
Rabbit nasal olfactory and respiratory microsomes were found to catalyze the α-hydroxylation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with specific activities of 262 and 136...
Huang, Mou-Tuan, Ho, Chi-Tang, Wang, Zhi Yuan, Ferraro, Thomas, Finnegan-Olive, Tara, Lou, You-Rong, ...
A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycydlic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical...
Guo, Zuyu, Smith, Theresa J., Wang, Erjia, Sadrieh, Nakissa, Ma, Qiang, Thomas, Paul E, ...
Phenethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables, has been shown to inhibit chemical carcinogenesis, possibly due to its ability to block the activation or to enhance the...
Hong, Jun-Yan, Wang, Zhi Yuan, Smith, Theresa J., Zhou, Shiqi, Shi, Stephanie, Pan, Jinmei, ...
Diallyl sulfide (DAS), a component of garlic oil, has been shown to inhibit tumorigenesis by several chemical carcinogens. Our previous work demonstrated that DAS inhibited the metabolic activation...
Smith, Theresa J., Guo, Zuyu, Jun-Hong, Yan, Ning, Shu M., Thomas, Paul E., Yang, Chung S.
The rat lung and nasal cavity are two target organs for carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In order to characterize further the enzymes involved in the...
Sohn, Ock Soon, Ishizaki, Hiroyuki, Yang, Chung S., Fiala, Emerich S.
The metabolism of azoxymethane (AOM), methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA) by liver microsomes from acetone-induced rats as well as by a reconstituted system containing...
Guo, Zuyu, Smith, Theresa J., Ishizaki, Hiroyuki, Yang, Chung S.
Several previous studies have suggested that cytochrome P450IIB1 is involved in the bioactivation of the tobaccospecific carcinogen, 4-(methylnitrosamino)-1-(3-pyridy1)-1-butanone (NNK), in rat as...
Yoo, Jeong-Sook H., Ishizaki, Hiroyuki, Yang, Chung S.
N-Nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) are widely occurring nitrosamines and require enzyme-catalyzed activation for their carcinogenic actions. The low Km forms of the enzyme...
Yang, Chung S., Koop, Dennis R., Wang, Tianyuan, Coon, Minor J.
The ethanol-induced rabbit liver microsomal cytochrome P-450, P-450LM3a, has been shown previously to efficiently catalyze the demethylation of N-nitrosodimethylamine (NDMA) with a Km of 2.9 mM....
The subcellular localization of N-nitrosodimethylamine (NDMA) demethylase in rat liver cells and the role of this enzyme in the activation of NDMA were studied. The enzyme activity was predominantly...
Peng, Renxiu, Tennant, Patrick, Lorr, Nancy A., Yang, Chung S.
The effects of diabetes on the liver microsomai monooxy-genase enzymes and carcinogen metabolism have been studied in rats. Treatment with streptozotocin causes a marked enhancement in microsomai...
Regioselective inhibition of benzo[a]pyrene metabolism by butylated hydroxyanisole (1983)
Sydor, Wasyl, Chou, Ming W., Yang, Shen K., Yang, Chung S.
The effects of butylated hydroxyanisole (BHA) on the metabolism of benzo[a]pyrene (BP) were investigated with mouse hepatic microsomes. Microsomes from BHA-fed mice showed a higher activity in...
Ping, Renxiu, Tu, Yityoong Yong, Yang, Chung S.
The effects of ethanol on the metabolism of nitrosamines by rat liver microsomes have been studied. Treatment of rats with 10 or 15% ethanol in drinking water for 3 days causes a 4- to 5-fold...
The nature of nitrosamine denitrosation by rat liver microsomes (1982)
Lorr, Nancy A., Tu, Yityoong Y., Yang, Chung S.
The nature of the denitrosation of nitrosamines by rat liver microsomes was investigated. The rates of NADPH-dependent nitrosamine demethylation and denitrosation were compared in the same incubation...
Lu, Yao-Ping, Lou, You-Rong, Xie, Jian-Guo, Peng, Qing-Yun, Liao, Jie, Yang, Chung S., ...
SKH-1 hairless mice were irradiated with ultraviolet B (UVB) twice weekly for 20 weeks. These tumor-free mice, which had a high risk of developing skin tumors during the next several months, were...
Rapid conformational changes of cytochrome P-450: Effect of dimyristoyl lecithin
Tsong, Tian Yow, Yang, Chung S.
Binding of benzphetamine to purified microsomal cytochrome P-450 from rat liver causes a shift in the heme spin state of the protein to favor the high-spin form. This shift is strongly temperature...
Lu, Yao-Ping, Lou, You-Rong, Xie, Jian-Guo, Peng, Qing-Yun, Liao, Jie, Yang, Chung S., ...
SKH-1 hairless mice were irradiated with ultraviolet B (UVB) twice weekly for 20 weeks. These tumor-free mice, which had a high risk of developing skin tumors during the next several months, were...
Rapid conformational changes of cytochrome P-450: Effect of dimyristoyl lecithin
Tsong, Tian Yow, Yang, Chung S.
Binding of benzphetamine to purified microsomal cytochrome P-450 from rat liver causes a shift in the heme spin state of the protein to favor the high-spin form. This shift is strongly temperature...
Chen, Xiaoxin, Qin, Rong, Liu, Ba, Ma, Yan, Su, Yinghao, Yang, Chung S, ...
Lambert, Joshua D., Kwon, Seok-Joo, Ju, Jihyeung, Bose, Mousumi, Lee, Mao-Jung, Hong, Jungil, ...
The green tea (Camellia sinensis) catechin, (-)-epigallocatechin-3-gallate (EGCG), has shown cancer-preventive activity in animal models. Previously, we have reported the bioavailability of EGCG in...