Claus Bachert

Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue (2009)

Patou, Joke, Holtappels, Gabriele, Affleck, Karen, Gevaert, Philippe, Perez-Novo, Claudina, Van Cauwenberge, Paul, ...

Abstract Background The mast cell is a crucial effector cell in allergic rhinitis and other inflammatory diseases. During the acute allergic reaction preformed mediators such as histamine, but also...

HUMAN MAST CELLS EXPRESS LEPTIN AND LEPTIN RECEPTORS (2009)

Taildeman, Jasmien, Perez Novo, Claudina, Rottiers, Isabelle, Ferdinande, Liesbeth, Waeytens, Anouk, De Colvenaer, Veerle, ...

Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic,...

Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients (2009)

Gevaert, Philippe, Hellman, C., Lundblad, L., Lundahl, J., Holtappels, Gabriële, Van Cauwenberge, Paul, ...

Given the key role of interleukin-5 (IL-5) in eosinophil function, we investigated the regulated expression of the membrane-anchored (TM-IL-5R alpha) isoform, or a secreted (SOL IL-5R alpha) isoform,...

Decreased FOXP3 protein expression in patients with asthma (2009)

Provoost, Sharen, Maes, Tania, Van Durme, Yannick, Gevaert, Philippe, Bachert, Claus, Schmidt-Weber, C.B., ...

Background: T-regulatory cells (T(reg)) are important in balancing immune responses and maintaining peripheral tolerance. Current evidence suggests that asthma is characterized by a relative...

Chronic rhinosinusitis with and without nasal polyps: what is the difference? (2009)

Huvenne, Wouter, Van Bruaene, Nicholas, Zhang, Nan, VAN ZELE, THIBAUT, Patou, Joke, Gevaert, Philippe, ...

Chronic rhinosinusitis is a heterogeneous group of chronic sinus diseases that may consist of clearly different disease entities. Further investigation of the pathomechanisms of chronic...

Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts (2008)

Perez Novo, Claudina, Waeytens, Anouk, Claeys, Cindy, Van Cauwenberge, Paul, Bachert, Claus

Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin...

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA(2)LEN paper (2008)

Bousquet, J, Fokkens, W, Burney, P, Durham, SR, Bachert, Claus, Akdis, CA, ...

Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people...

Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps (2008)

Patou, Joke, Gevaert, Philippe, VAN ZELE, THIBAUT, Holtappels, Gabriële, Van Cauwenberge, Paul, Bachert, Claus

Background: Increasing evidence points toward a modifying role of Staphylococcus aureus and its products in the pathogenesis of nasal polyposis. Objective: The aim of this study was to investigate...

Role of staphylococcal superantigens in upper airway disease (2008)

Bachert, Claus, Zhang, Nan, Patou, Joke, VAN ZELE, THIBAUT, Gevaert, Philippe

Purpose of review Chronic rhinosinusitis with nasal polyps often represents a chronic severe inflammatory disease of the upper airways and may serve as a model for lower airway diseases such as...

Rupatadine in allergic rhinitis and chronic urticaria (2008)

Mullo, J., Bousquet, J., Bachert, Claus, Canonica, W. G., Gimenez-Arnau, A., Kowalski, M. L., ...

Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H-1-receptor antagonists have in the...

Long-term treatment of persistent allergic rhinitis with levocetirizine (2007)

Klimek, Ludger, Bachert, Claus, Canonica, G. Walter, Durham, Stephen R., Mullol, Joaquim, Van Cauwenberge, Paul, ...

Background: The impact of treatment on specific aspects of health-related quality of life (HRQOL), including limitations in particular activities and quality of sleep, has not been clarified in...

Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis (2006)

Scadding, Glenis K, Badia, Lydia, Mullol, Joaquim, ...

BACKGROUND: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. Recently, it has been suggested that an exaggerated immune response to fungi is crucial in the pathogenesis of the...

Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin B (2006)

Gevaert, Philippe, ...

BACKGROUND: The role of bacterial enterotoxins like Staphylococcus aureus enterotoxin B (SEB) in allergic asthma remains unknown. We used a mouse model of airway allergy to study the effects of nasal...

Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis (2006)

Pérez-Novo, Claudina, Claeys, Cindy, Van Cauwenberge, Paul, Bachert, Claus

Abstract Background Eicosanoid receptors are G-protein-coupled receptors playing an important immunomodulatory role in airway diseases. However, there is little information on the expression of these...

Quantitative Real Time Polymerase Chain Reaction for measurement of human Interleukin – 5 receptor alpha spliced isoforms mRNA (2003)

Pérez, Claudina, Vandesompele, Jo, Vandenbroucke, Ina, Holtappels, Gabriele, Speleman, Frank, Gevaert, Philippe, ...

Abstract Background Expression of human Interleukin-5 receptor alpha (hIL-5Rα) is controlled by alternative splicing, which generates two different transcripts encoding a membrane-anchored and a...

Surgery of inverted papillomas under endoscopic control (2000)

Eloy, Philippe, Rombaux, Philippe, Daele, Jacques, Boniver, Vincent, ...

Six centers cooperated in a retrospective study on endoscopic surgical resection of Papillomas of the nose and paranasal sinuses in order to assess both the efficiency and the safety of this kind of...

Endoscopic sinus surgery for juvenile nasopharyngeal angiofibroma (2000)

Eloy, Philippe, Rombaux, Philippe, Bachert, Claus, Daele, Jacques

Juvenile nasopharyngeal angiofibroma is a rare tumour of the head and neck with very specific characteristics: adolescent males, choana-nasopharynx, pterygomaxillary fossa widening, specific and...

Management of persistent allergic rhinitis: evidence-based treatment with levocetirizine

Mullol, Joaquim, Bachert, Claus, Bousquet, Jean

Allergic rhinitis (AR) is a major health problem that can significantly impair quality of life (QoL). The former classification of AR comprises seasonal allergic rhinitis (SAR) and perennial allergic...