Farago, Oded, Ewert, Kai, Ahmad, Ayesha, Evans, Heather M., Gr\onbech-Jensen, Niels, Safinya, Cyrus R.
We use X-ray scattering and molecular simulations to investigate the structural properties of complexes of multivalent cationic lipids and DNA molecules. At low mole fraction of neutral lipids (NLs),...
Lamellar Phase of Stacked Two-Dimensional Rafts of Actin Filaments (2003)
Wong, Gerard C.L., Lin, Alison, Tang, Jay X., Li, Youli, Janmey, Paul, Safinya, Cyrus R
We examined liquid crystalline phases of the cytoskeletal polyelectrolyte filamentous (F-)actin in the presence of multivalent counterions. As a function of increasing ion concentration, the F-actin...
Applications of Self-Assembly (1998)
Mashhood Ishaque, Advisor Diane Souvaine, Committee Judith Stafford, Lenore Cowen, ...
Self-assembly is the
A phase of liposomes with entangled tubular vesicles (1994)
Chiruvolu, Shivkumar, Warriner, Heidi E., Naranjo, Edward, Idziak, Stefan H. J., Rädler, Joachim O., Plano, Robert J., ...
An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble...
DNA condensation in two dimensions
Koltover, Ilya, Wagner, Kathrin, Safinya, Cyrus R.
We have found that divalent electrolyte counterions common in biological cells (Ca2+, Mg2+, and Mn2+ ) can condense anionic DNA molecules confined to two-dimensional cationic surfaces. DNA-condensing...
Higher-order assembly of microtubules by counterions: From hexagonal bundles to living necklaces
Needleman, Daniel J., Ojeda-Lopez, Miguel A., Raviv, Uri, Miller, Herbert P., Wilson, Leslie, Safinya, Cyrus R.
Cellular factors tightly regulate the architecture of bundles of filamentous cytoskeletal proteins, giving rise to assemblies with distinct morphologies and physical properties, and a similar control...
Ordered patterns of liquid crystal toroidal defects by microchannel confinement
Choi, Myung Chul, Pfohl, Thomas, Wen, Zhiyu, Li, Youli, Kim, Mahn Won, Israelachvili, Jacob N., ...
In this article we present experimental results demonstrating an approach to controlling the size and spatial patterning of defect domains in a smectic liquid crystal (LC) by geometric confinement in...
Raviv, Uri, Needleman, Daniel J., Li, Youli, Miller, Herbert P., Wilson, Leslie, Safinya, Cyrus R.
Intermolecular interactions between charged membranes and biological polyelectrolytes, tuned by physical parameters, which include the membrane charge density and bending rigidity, the membrane...
Lin, Alison J., Slack, Nelle L., Ahmad, Ayesha, George, Cyril X., Samuel, Charles E., Safinya, Cyrus R.
Cationic liposomes (CLs) are used worldwide as gene vectors (carriers) in nonviral clinical applications of gene delivery, albeit with unacceptably low transfection efficiencies (TE). We present...
Martin-Herranz, Ana, Ahmad, Ayesha, Evans, Heather M., Ewert, Kai, Schulze, Uwe, Safinya, Cyrus R.
Cationic lipid-DNA (CL-DNA) complexes are abundantly used in nonviral gene therapy clinical applications. Surface functionality is the next step in developing these complexes as competent,...
Radial Compression of Microtubules and the Mechanism of Action of Taxol and Associated Proteins
Needleman, Daniel J., Ojeda-Lopez, Miguel A., Raviv, Uri, Ewert, Kai, Miller, Herbert P., Wilson, Leslie, ...
Microtubules (MTs) are hollow cylindrical polymers composed of αβ-tubulin heterodimers that align head-to-tail in the MT wall, forming linear protofilaments that interact laterally. We introduce a...
DNA condensation in two dimensions
Koltover, Ilya, Wagner, Kathrin, Safinya, Cyrus R.
We have found that divalent electrolyte counterions common in biological cells (Ca2+, Mg2+, and Mn2+ ) can condense anionic DNA molecules confined to two-dimensional cationic surfaces. DNA-condensing...
Higher-order assembly of microtubules by counterions: From hexagonal bundles to living necklaces
Needleman, Daniel J., Ojeda-Lopez, Miguel A., Raviv, Uri, Miller, Herbert P., Wilson, Leslie, Safinya, Cyrus R.
Cellular factors tightly regulate the architecture of bundles of filamentous cytoskeletal proteins, giving rise to assemblies with distinct morphologies and physical properties, and a similar control...
Ordered patterns of liquid crystal toroidal defects by microchannel confinement
Choi, Myung Chul, Pfohl, Thomas, Wen, Zhiyu, Li, Youli, Kim, Mahn Won, Israelachvili, Jacob N., ...
In this article we present experimental results demonstrating an approach to controlling the size and spatial patterning of defect domains in a smectic liquid crystal (LC) by geometric confinement in...
Raviv, Uri, Needleman, Daniel J., Li, Youli, Miller, Herbert P., Wilson, Leslie, Safinya, Cyrus R.
Intermolecular interactions between charged membranes and biological polyelectrolytes, tuned by physical parameters, which include the membrane charge density and bending rigidity, the membrane...
Lin, Alison J., Slack, Nelle L., Ahmad, Ayesha, George, Cyril X., Samuel, Charles E., Safinya, Cyrus R.
Cationic liposomes (CLs) are used worldwide as gene vectors (carriers) in nonviral clinical applications of gene delivery, albeit with unacceptably low transfection efficiencies (TE). We present...
Martin-Herranz, Ana, Ahmad, Ayesha, Evans, Heather M., Ewert, Kai, Schulze, Uwe, Safinya, Cyrus R.
Cationic lipid-DNA (CL-DNA) complexes are abundantly used in nonviral gene therapy clinical applications. Surface functionality is the next step in developing these complexes as competent,...
Radial Compression of Microtubules and the Mechanism of Action of Taxol and Associated Proteins
Needleman, Daniel J., Ojeda-Lopez, Miguel A., Raviv, Uri, Ewert, Kai, Miller, Herbert P., Wilson, Leslie, ...
Microtubules (MTs) are hollow cylindrical polymers composed of αβ-tubulin heterodimers that align head-to-tail in the MT wall, forming linear protofilaments that interact laterally. We introduce a...
Raviv, Uri, Nguyen, Toan, Ghafouri, Rouzbeh, Needleman, Daniel J., Li, Youli, Miller, Herbert P., ...
Microtubules are able to adjust their protofilament (PF) number and, as a consequence, their dynamics and function, to the assembly conditions and presence of cofactors. However, the principle behind...
Transitions between Distinct Compaction Regimes in Complexes of Multivalent Cationic Lipids and DNA
Farago, Oded, Ewert, Kai, Ahmad, Ayesha, Evans, Heather M., Grønbech-Jensen, Niels, Safinya, Cyrus R.
Cationic lipids (CLs) have found widespread use as nonviral gene carriers (vectors), including applications in clinical trials of gene therapy. However, their observed transfection efficiencies (TEs)...
Interplay between Liquid Crystalline and Isotropic Gels in Self-Assembled Neurofilament Networks
Jones, Jayna B., Safinya, Cyrus R.
Neurofilaments (NFs) are a major constituent of nerve cell axons that assemble from three subunit proteins of low (NF-L), medium (NF-M), and high (NF-H) molecular weight into a 10 nm diameter rod...