D. Brenner

Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes (2007)

Brenner, D., Golks, A., Becker, M., Muller, W., Frey, C. R., Novak, R., ...

Life and death of peripheral lymphocytes is strictly controlled to maintain physiologic levels of T and B cells. Activation-induced cell death (AICD) is one mechanism to delete superfluous...

Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation (2007)

Arnold, R., Frey, C. R., Muller, W., Brenner, D., Krammer, P. H., Kiefer, F.

We studied monocytic differentiation of primary mouse progenitor cells to understand molecular mechanisms of differentiation. We found a tightly controlled non-apoptotic activation of caspase-3 that...