S L Hockley, A Morilla, M Else, C Dearden, D Catovsky, G J Morgan, ...
Catovsky, D., Richards, S., Matutes, E., Oscier, D., Dyer, M.J.S., FBezares, R., ...
Background: Previous studies of patients with chronic lymphocytic leukaemia reported high response rates to fludarabine combined with cyclophosphamide. We aimed to establish whether this treatment...
I Del Giudice, Z Davis, E Matutes, N Osuji, N Parry-Jones, A Morilla, ...
A Carter, K Lin, P D Sherrington, M Atherton, K Pearson, A Douglas, ...
R S Boyd, P J Adam, S Patel, J A Loader, J Berry, N T Redpath, ...
Activity of oral fludarabine phosphate in previously treated chronic lymphocytic leukemia (2001)
Boogaerts, Marc; U0009270 JFA; CORA, Van Hoof, A, Catovsky, D, Kovacs, M, Montillo, M, Zinzani, P L, ...
PURPOSE: A prospective, multicenter, open-label phase II clinical trial was conducted to assess the efficacy and safety of oral fludarabine phosphate. Reference to an historical group of patients...
High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H (2001)
Dearden, C.E., Matutes, E., Cazin, B., Tjonnfjord, G.E., Parreira, A., Nomdedeu, B., ...
Willis, T G ; JFA; CORA, Zalcberg, I R, Coignet, L J, Wlodarska, Iwona; U0009823 ;, Stul, Michel; U0015041 ;, Jadayel, D M, ...
Abnormalities of chromosome 1q21 are common in B-cell malignancies and have been associated with a poor response to therapy. The nature of the involved gene(s) on chromosome 1q21 remains unknown. A...
Conchon, M ; JFA; CORA, McManus, AP, Min, T, Maljaie, SH, Crawford, Alexander; U0045843 ;, BritoBabapulle, V, ...
The translocation t(12;22)(p13;q11) has been consistently described in myeloid malignancies and shown to result from a fusion between the TEL and MN1 genes. Previously described deletions of 12p in...
Expression of TIA-1 and TIA-2 in T cell malignancies and T cell lymphocytosis (1996)
Matutes, E ; JFA; CORA, Coelho, E, Aguado, MJ, Morilla, R, Crawford, Alexander; U0045843 ;, OwusuAnkomah, K, ...
Objective-To investigate the reactivity with TIA-1 and TIA-2, two monoclonal antibodies that recognise, respectively, granular structures in T lymphocyres and the T cell receptor chain in cells from...
Expression of tia-1 and tia-2 in t-cell malignancies and t-lymphocytosis (1994)
Matutes, E ; JFA; CORA, Coelho, E, Aguado, Mj, Morilla, R, Crawford, Alexander; U0045843 ;, Owusuankomah, K, ...
Strohscheer, I., Kleinert, R., Westphal, C., Schüller, J., Werner, K., Anders, O., ...
Peer Reviewed
Britobabapulle, V ; JFA; CORA, Crawford, Alexander; U0045843 ;, Khokhar, T, Laffan, M, Matutes, E, Fairhead, S, ...
Follicular lymphoma is a low grade malignancy characterized by the translocation t(14;18), which involves the putative oncogene bcl-2. We describe a 73-year-old patient presenting with Burkitt acute...
Hypokalaemia and Raised Lysozyme Levels in Acute Myeloid Leukaemia (1973)
PICKERING, T. G., CATOVSKY, D.
In an unselected series of 50 patients with untreated acute myeloid leukaemia (myeloblastic, monocytic, and myelomonocytic) 12 (24 per cent) had a plasma potassium level of less than 3.5 mEq/l;...
Incluye bibliografía
Miedema, F, Van Oostveen, J W, Terpstra, F G, Van Den Wall Bake, A W, Willemze, R, Rauws, E A, ...
The neoplastic T cells of a series of seven patients with chronic T-cell neoplasia were tested for helper activity on pokeweed mitogen (PWM)-induced and interleukin 2 (IL-2)-induced Ig synthesis. The...
Catovsky, D., Galetto, J., Okos, A., Miliani, E., Galton, D. A. G.
The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic...
Immunological studies in a case of T-cell leukaemia
Stathopoulos, G., Papamichail, M., Sheldon, P., Catovsky, D., Davies, A. J. S., Holborow, E. J., ...
The blood lymphocytes from a case of prolymphocytic leukaemia were subjected to a battery of different tests in order to establish as certainly as possible their T or B cell type of origin. The...
Bain, B, Catovsky, D, O'Brien, M, Spiers, A S, Richards, G H
Morphological, cytochemical, and ultrastructural electron microscopic (EM) studies were performed on blood and bone-marrow cells of case of Ph1-positive chronic ganulocytic leukaemia in...
Lysozyme activity and nitroblue-tetrazolium reduction in leukaemic cells
Catovsky, D., Galton, D. A. G.
The cytochemical methods for lysozyme and nitroblue-tetrazolium reduction have been used to study the blast cells of acute myeloid leukaemia. Both proved useful in characterizing the cases with...
Demonstration of cytoplasmic and nuclear antigens in acute leukaemia using flow cytometry.
Farahat, N, Van Der Plas, D, Praxedes, M, Morilla, R, Matutes, E, Catovsky, D
AIMS--To detect cytoplasmic and nuclear antigens using flow cytometry in acute leukaemia and to use this technique for double marker combinations. METHODS--Cytoplasmic staining was carried out in...
Characterisation of normal peripheral blood cells in cycle identified by monoclonal antibody Ki-67.
Cordone, I, Matutes, E, Catovsky, D
AIMS: To investigate the numbers, morphology, and lineage assignment of Ki-67 positive cells in peripheral blood from normal subjects. METHODS: Single and double immunoenzymatic staining procedures,...
Lymphoma-like presentation of acute monocytic leukaemia.
Bain, B, Manoharan, A, Lampert, I, McKenzie, C, Catovsky, D
Four patients in whom a diagnosis of acute monocytic leukaemia (M5) was subsequently made presented with extramedullary disease clinically resembling lymphoma. In all patients histological sections...
Rowe, I F, Worsley, A M, Donnelly, P, Catovsky, D, Goldman, J M, Galton, D, ...
C reactive protein concentration was measured serially in 19 patients with leukaemia after bone marrow transplantation. Six episodes of graft versus host disease occurred in the presence of fever but...
Tavares De Castro, J, San Miguel, J F, Soler, J, Catovsky, D
A method for the simultaneous labelling of terminal deoxynucleotidyl transferase (TdT) and membrane antigens is described. TdT is visualised in the cell nucleus with the peroxidase-antiperoxidase...
Bone marrow fibre content in acute myeloid leukaemia before and after treatment.
Islam, A, Catovsky, D, Goldman, J M, Galton, D A
Bone marrow fibre content was studied in 34 patients with acute myeloid leukaemia at presentation and subsequently after chemotherapy and at complete remission. The findings indicate that: some...
Biphenotypic leukaemia: a case of mixed T lymphoblastic and myeloblastic leukaemia.
Morgan, M A, Scott, C S, Tavares De Castro, J, Limbert, H J, Polli, N, Catovsky, D, ...
A case of mixed acute leukaemia with T lymphoblastic, myeloblastic, and monocytic components is described. The use of immunological markers, ultrastructural morphology, cytochemistry,...
Robinson, D S, Melo, J V, Andrews, C, Schey, S A, Catovsky, D
The intracytoplasmic inclusions seen in most cells from a patient with B prolymphocytic leukaemia were analysed using both light and electron microscopy. They consisted of a dense homogeneous...
Hypercalcaemia in T cell acute lymphoblastic leukaemia: report of two cases.
Laffan, M A, Talavera, J G, Catovsky, D
Two young adults presenting with acute lymphoblastic leukaemia (ALL) associated with hypercalcaemia and osteolytic lesions were both found to have T cell ALL. Hypercalcaemia is a rare feature of ALL...
Expression of TIA-1 and TIA-2 in T cell malignancies and T cell lymphocytosis.
Matutes, E, Coelho, E, Aguado, M J, Morilla, R, Crawford, A, Owusu-Ankomah, K, ...
OBJECTIVE: To investigate the reactivity with TIA-1 and TIA-2, two monoclonal antibodies that recognise, respectively, granular structures in T lymphocytes and the T cell receptor chain in cells from...
Association between sarcoidosis and lymphoma revisited.
Karakantza, M, Matutes, E, MacLennan, K, O'Connor, N T, Srivastava, P C, Catovsky, D
AIMS: To investigate the relation between sarcoidosis and lymphoma. METHODS: The hospital notes of five patients with sarcoidosis and a lymphoproliferative disorder were reviewed. Histological...
Ginaldi, L, Farahat, N, Matutes, E, De Martinis, M, Morilla, R, Catovsky, D
AIMS: To obtain reference values of the level of expression of T cell antigens on normal lymphocyte subsets in order to disclose differences which could reflect their function or maturation stages,...
Levels of expression of CD19 and CD20 in chronic B cell leukaemias.
Ginaldi, L, De Martinis, M, Matutes, E, Farahat, N, Morilla, R, Catovsky, D
AIMS: To investigate whether the antigen levels of the B cell lineage markers CD19 and CD20 can distinguish between normal and neoplastic B cells or characterise distinct expression patterns among...
Immunological and ultrastructural studies in acute biphenotypic leukaemia.
Shetty, V, Chitale, A, Matutes, E, Buccheri, V, Morilla, R, Catovsky, D
AIMS--To compare the sensitivity of the ultrastructural method to detect myeloperoxidase (MPO) with light microscopy and immunocytochemistry using an anti-MPO antibody; to examine the expression of...
Leukaemic phase of mantle zone (intermediate) lymphoma: its characterisation in 11 cases.
De Oliveira, M S, Jaffe, E S, Catovsky, D
Sixteen patients presented with B cell leukaemia (white cell count 26-269 x 10(9)/l) which could not be classified as chronic lymphocytic (CLL), prolymphocytic leukaemia, or follicular lymphoma in...
Circulating Ki67 positive lymphocytes in multiple myeloma and benign monoclonal gammopathy.
Miguel-Garcia, A, Matutes, E, Tarin, F, Garcia-Talavera, J, Miguel-Sosa, A, Carbonell, F, ...
AIMS--To estimate the proportion and nature of the proliferating (Ki67+) circulating lymphocytes in a series of patients with multiple myeloma and monoclonal gammopathy of unknown significance (MGUS)...
Heterogeneity of T-cell beta-chain gene rearrangements in human leukaemias and lymphomas.
Rabbitts, T H, Stinson, A, Forster, A, Foroni, L, Luzzatto, L, Catovsky, D, ...
The state of T-cell receptor beta-chain gene rearrangement in human T-cell leukaemias has been analysed. All forms of leukaemia tested (T-CLL, ALL, PLL, Sezary syndrome and ATL) exhibit...
Haralambidou, S, Melo, J V, Catovsky, D
The reactivity of five monoclonal antibodies J5, OKB-cALLA, Nu-N1, Nu-N2 and VIL-A1 against the common acute lymphoblastic leukaemia (common-ALL) antigen (glycoprotein 100, CD10); was investigated by...
Melo, J V, Hegde, U, Parreira, A, Thompson, I, Lampert, I A, Catovsky, D
The clinical, haematological, morphological and histological features of a series of 22 patients presenting with splenic lymphoma with circulating villous lymphocytes were assessed and compared with...
Pombo De Oliveira, M S, Gregory, C, Matutes, E, Parreira, A, Catovsky, D
A cytochemical study using: Sudan black B; alpha-naphthyl acetate (ANAE) staining; estimation of alpha-naphthyl butyrate (ANBE) esterase activity; acid phosphatase activity; and 5' nucleotidase...
Yamaguchi, K, Matutes, E, Kiyokawa, T, Nishimura, Y, Ishii, T, Takatsuki, K, ...
Serum antibodies against human T cell leukaemia virus type I (HTLV-I) were investigated in 12 patients by four methods: indirect immunoperoxidase staining, indirect immunofluorescence, enzyme linked...
Morphology and immunology of circulating cells in leukaemic phase of follicular lymphoma.
Melo, J V, Robinson, D S, De Oliveira, M P, Thompson, I W, Lampert, I A, Ng, J P, ...
Ten patients with follicular lymphoma presented with a high white cell count (45-220 x 10(9)/l) which resembled chronic lymphocytic leukaemia (CCL): all had pronounced splenomegaly and, except one,...
Bennett, J M, Catovsky, D, Daniel, M T, Flandrin, G, Galton, D A, Gralnick, H R, ...
Peripheral blood, bone marrow films, and bone marrow biopsy specimens from 110 patients, well characterised by clinical and laboratory studies, including electron microscopy, were reviewed, to...
Significance of Phi bodies in acute leukaemia.
Cardullo, L De S, Morilla, R, Catovsky, D
Material from 39 patients with acute leukaemia was investigated with the peroxidase cytochemical reaction using 3,3'diaminobenzidine (DAB) and other substrates in order to test their sensitivity in...
Membrane phenotype and response to deoxycoformycin in mature T cell malignancies.
Dearden, C E, Matutes, E, Hoffbrand, A V, Ganeshaguru, K, Brozovic, M, Williams, H J, ...
The adenosine deaminase inhibitor deoxycoformycin was used in low doses to treat 19 patients with clinically aggressive T cell malignancy with a mature membrane phenotype. The patients comprised...
Immunoreactive calcitonin in leukaemia.
Hillyard, C J, Oscier, D G, Foa, R, Catovsky, D, Goldman, J M
A radioimmunoassay was used to measure concentrations of immunoreactive human calcitonin (HCT) in plasma and leucocytes from patients with various leukaemic and myeloproliferative disorders. Plasma...
Goldman, J M, Catovsky, D, Hows, J, Spiers, A S, Galton, D A
Six patients with chronic granulocytic leukaemia (CGL) in transformation were treated with cytotoxic drugs or cytotoxic drugs plus total body irradiation, followed by infusion of reconstituted...
Chronic Granulocytic Leukaemia: Multiple-drug Chemotherapy for Acute Transformation
Spiers, A. D. S., Costello, Christine, Catovsky, D., Galton, D. A. G., Goldman, J. M.
The response to 60 trials of therapy in 50 patients with chronic granulocytic leukaemia (C.G.L.) in acute transformation is reported. None of the 13 patients who received single-agent chemotherapy...
T-lymphoblastic Leukaemia: A Distinct Variant of Acute Leukaemia
Catovsky, D., Goldman, J. M., Okos, A., Frisch, B., Galton, D. A. G.
Two cases of acute lymphoblastic leukaemia (A.L.L.) of T-cell type are reported. Clinically they were characterized by very high peripheral blood blast cell counts at presentation, the early...
Prolonged remission maintenance in acute myeloid leukaemia.
Spiers, A S, Goldman, J M, Catovsky, D, Costello, C, Galton, D A, Pitcher, C S
Twenty-five patients with acute myeloid leukaemia were treated with three quadruple drug combinations in predetermined rotation: TRAP (thioguanine, daunorubicin, cytarabine, prednisolone); COAP...
Chronic Granulocytic Leukaemia: Effect of Elective Splenectomy on the Course of Disease
Spiers, A. S. D., Baikie, A. G., Galton, D. A. G., Richards, H. G. H., Wiltshaw, E., Goldman, J. M., ...
Conventional treatment by drugs or irradiation produces little prolongation of life in patients with chronic granulocytic leukaemia (C.G.L.) because the onset of metamorphosis of the disease from a...
Thromboembolic Complications in Myelomatosis
Catovsky, D., Ikoku, N. B., Pitney, W. R., Galton, D. A. G.
Fourteen cases of myelomatosis associated with major thromboembolic complications are reported. Six patients died of pulmonary embolism, seven had deep-vein thrombosis as a presenting symptom, and...
Miedema, F, Van Oostveen, J W, Terpstra, F G, Van Den Wall Bake, A W, Willemze, R, Rauws, E A, ...
The neoplastic T cells of a series of seven patients with chronic T-cell neoplasia were tested for helper activity on pokeweed mitogen (PWM)-induced and interleukin 2 (IL-2)-induced Ig synthesis. The...
Catovsky, D., Galetto, J., Okos, A., Miliani, E., Galton, D. A. G.
The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic...
Immunological studies in a case of T-cell leukaemia
Stathopoulos, G., Papamichail, M., Sheldon, P., Catovsky, D., Davies, A. J. S., Holborow, E. J., ...
The blood lymphocytes from a case of prolymphocytic leukaemia were subjected to a battery of different tests in order to establish as certainly as possible their T or B cell type of origin. The...
Bain, B, Catovsky, D, O'Brien, M, Spiers, A S, Richards, G H
Morphological, cytochemical, and ultrastructural electron microscopic (EM) studies were performed on blood and bone-marrow cells of case of Ph1-positive chronic ganulocytic leukaemia in...
Lysozyme activity and nitroblue-tetrazolium reduction in leukaemic cells
Catovsky, D., Galton, D. A. G.
The cytochemical methods for lysozyme and nitroblue-tetrazolium reduction have been used to study the blast cells of acute myeloid leukaemia. Both proved useful in characterizing the cases with...
Demonstration of cytoplasmic and nuclear antigens in acute leukaemia using flow cytometry.
Farahat, N, Van Der Plas, D, Praxedes, M, Morilla, R, Matutes, E, Catovsky, D
AIMS--To detect cytoplasmic and nuclear antigens using flow cytometry in acute leukaemia and to use this technique for double marker combinations. METHODS--Cytoplasmic staining was carried out in...
Characterisation of normal peripheral blood cells in cycle identified by monoclonal antibody Ki-67.
Cordone, I., Matutes, E., Catovsky, D.
AIMS: To investigate the numbers, morphology, and lineage assignment of Ki-67 positive cells in peripheral blood from normal subjects. METHODS: Single and double immunoenzymatic staining procedures,...
Lymphoma-like presentation of acute monocytic leukaemia.
Bain, B, Manoharan, A, Lampert, I, McKenzie, C, Catovsky, D
Four patients in whom a diagnosis of acute monocytic leukaemia (M5) was subsequently made presented with extramedullary disease clinically resembling lymphoma. In all patients histological sections...
Rowe, I F, Worsley, A M, Donnelly, P, Catovsky, D, Goldman, J M, Galton, D, ...
C reactive protein concentration was measured serially in 19 patients with leukaemia after bone marrow transplantation. Six episodes of graft versus host disease occurred in the presence of fever but...
Tavares De Castro, J, San Miguel, J F, Soler, J, Catovsky, D
A method for the simultaneous labelling of terminal deoxynucleotidyl transferase (TdT) and membrane antigens is described. TdT is visualised in the cell nucleus with the peroxidase-antiperoxidase...
Bone marrow fibre content in acute myeloid leukaemia before and after treatment.
Islam, A, Catovsky, D, Goldman, J M, Galton, D A
Bone marrow fibre content was studied in 34 patients with acute myeloid leukaemia at presentation and subsequently after chemotherapy and at complete remission. The findings indicate that: some...
Biphenotypic leukaemia: a case of mixed T lymphoblastic and myeloblastic leukaemia.
Morgan, M A, Scott, C S, Tavares De Castro, J, Limbert, H J, Polli, N, Catovsky, D, ...
A case of mixed acute leukaemia with T lymphoblastic, myeloblastic, and monocytic components is described. The use of immunological markers, ultrastructural morphology, cytochemistry,...
Robinson, D S, Melo, J V, Andrews, C, Schey, S A, Catovsky, D
The intracytoplasmic inclusions seen in most cells from a patient with B prolymphocytic leukaemia were analysed using both light and electron microscopy. They consisted of a dense homogeneous...
Hypercalcaemia in T cell acute lymphoblastic leukaemia: report of two cases.
Laffan, M A, Talavera, J G, Catovsky, D
Two young adults presenting with acute lymphoblastic leukaemia (ALL) associated with hypercalcaemia and osteolytic lesions were both found to have T cell ALL. Hypercalcaemia is a rare feature of ALL...
Expression of TIA-1 and TIA-2 in T cell malignancies and T cell lymphocytosis.
Matutes, E, Coelho, E, Aguado, M J, Morilla, R, Crawford, A, Owusu-Ankomah, K, ...
OBJECTIVE: To investigate the reactivity with TIA-1 and TIA-2, two monoclonal antibodies that recognise, respectively, granular structures in T lymphocytes and the T cell receptor chain in cells from...
Association between sarcoidosis and lymphoma revisited.
Karakantza, M, Matutes, E, MacLennan, K, O'Connor, N T, Srivastava, P C, Catovsky, D
AIMS: To investigate the relation between sarcoidosis and lymphoma. METHODS: The hospital notes of five patients with sarcoidosis and a lymphoproliferative disorder were reviewed. Histological...
Ginaldi, L, Farahat, N, Matutes, E, De Martinis, M, Morilla, R, Catovsky, D
AIMS: To obtain reference values of the level of expression of T cell antigens on normal lymphocyte subsets in order to disclose differences which could reflect their function or maturation stages,...
Levels of expression of CD19 and CD20 in chronic B cell leukaemias.
Ginaldi, L, De Martinis, M, Matutes, E, Farahat, N, Morilla, R, Catovsky, D
AIMS: To investigate whether the antigen levels of the B cell lineage markers CD19 and CD20 can distinguish between normal and neoplastic B cells or characterise distinct expression patterns among...
Immunological and ultrastructural studies in acute biphenotypic leukaemia.
Shetty, V, Chitale, A, Matutes, E, Buccheri, V, Morilla, R, Catovsky, D
AIMS--To compare the sensitivity of the ultrastructural method to detect myeloperoxidase (MPO) with light microscopy and immunocytochemistry using an anti-MPO antibody; to examine the expression of...
Leukaemic phase of mantle zone (intermediate) lymphoma: its characterisation in 11 cases.
De Oliveira, M S, Jaffe, E S, Catovsky, D
Sixteen patients presented with B cell leukaemia (white cell count 26-269 x 10(9)/l) which could not be classified as chronic lymphocytic (CLL), prolymphocytic leukaemia, or follicular lymphoma in...
Circulating Ki67 positive lymphocytes in multiple myeloma and benign monoclonal gammopathy.
Miguel-Garcia, A, Matutes, E, Tarin, F, Garcia-Talavera, J, Miguel-Sosa, A, Carbonell, F, ...
AIMS--To estimate the proportion and nature of the proliferating (Ki67+) circulating lymphocytes in a series of patients with multiple myeloma and monoclonal gammopathy of unknown significance (MGUS)...
Heterogeneity of T-cell beta-chain gene rearrangements in human leukaemias and lymphomas.
Rabbitts, T H, Stinson, A, Forster, A, Foroni, L, Luzzatto, L, Catovsky, D, ...
The state of T-cell receptor beta-chain gene rearrangement in human T-cell leukaemias has been analysed. All forms of leukaemia tested (T-CLL, ALL, PLL, Sezary syndrome and ATL) exhibit...
Haralambidou, S, Melo, J V, Catovsky, D
The reactivity of five monoclonal antibodies J5, OKB-cALLA, Nu-N1, Nu-N2 and VIL-A1 against the common acute lymphoblastic leukaemia (common-ALL) antigen (glycoprotein 100, CD10); was investigated by...
Melo, J V, Hegde, U, Parreira, A, Thompson, I, Lampert, I A, Catovsky, D
The clinical, haematological, morphological and histological features of a series of 22 patients presenting with splenic lymphoma with circulating villous lymphocytes were assessed and compared with...
Pombo De Oliveira, M S, Gregory, C, Matutes, E, Parreira, A, Catovsky, D
A cytochemical study using: Sudan black B; alpha-naphthyl acetate (ANAE) staining; estimation of alpha-naphthyl butyrate (ANBE) esterase activity; acid phosphatase activity; and 5' nucleotidase...
Yamaguchi, K, Matutes, E, Kiyokawa, T, Nishimura, Y, Ishii, T, Takatsuki, K, ...
Serum antibodies against human T cell leukaemia virus type I (HTLV-I) were investigated in 12 patients by four methods: indirect immunoperoxidase staining, indirect immunofluorescence, enzyme linked...
Morphology and immunology of circulating cells in leukaemic phase of follicular lymphoma.
Melo, J V, Robinson, D S, De Oliveira, M P, Thompson, I W, Lampert, I A, Ng, J P, ...
Ten patients with follicular lymphoma presented with a high white cell count (45-220 x 10(9)/l) which resembled chronic lymphocytic leukaemia (CCL): all had pronounced splenomegaly and, except one,...
Bennett, J M, Catovsky, D, Daniel, M T, Flandrin, G, Galton, D A, Gralnick, H R, ...
Peripheral blood, bone marrow films, and bone marrow biopsy specimens from 110 patients, well characterised by clinical and laboratory studies, including electron microscopy, were reviewed, to...
Significance of Phi bodies in acute leukaemia.
Cardullo, L De S, Morilla, R, Catovsky, D
Material from 39 patients with acute leukaemia was investigated with the peroxidase cytochemical reaction using 3,3'diaminobenzidine (DAB) and other substrates in order to test their sensitivity in...
Membrane phenotype and response to deoxycoformycin in mature T cell malignancies.
Dearden, C E, Matutes, E, Hoffbrand, A V, Ganeshaguru, K, Brozovic, M, Williams, H J, ...
The adenosine deaminase inhibitor deoxycoformycin was used in low doses to treat 19 patients with clinically aggressive T cell malignancy with a mature membrane phenotype. The patients comprised...
Immunoreactive calcitonin in leukaemia.
Hillyard, C J, Oscier, D G, Foa, R, Catovsky, D, Goldman, J M
A radioimmunoassay was used to measure concentrations of immunoreactive human calcitonin (HCT) in plasma and leucocytes from patients with various leukaemic and myeloproliferative disorders. Plasma...
Goldman, J M, Catovsky, D, Hows, J, Spiers, A S, Galton, D A
Six patients with chronic granulocytic leukaemia (CGL) in transformation were treated with cytotoxic drugs or cytotoxic drugs plus total body irradiation, followed by infusion of reconstituted...
Chronic Granulocytic Leukaemia: Multiple-drug Chemotherapy for Acute Transformation
Spiers, A. D. S., Costello, Christine, Catovsky, D., Galton, D. A. G., Goldman, J. M.
The response to 60 trials of therapy in 50 patients with chronic granulocytic leukaemia (C.G.L.) in acute transformation is reported. None of the 13 patients who received single-agent chemotherapy...
T-lymphoblastic Leukaemia: A Distinct Variant of Acute Leukaemia
Catovsky, D., Goldman, J. M., Okos, A., Frisch, B., Galton, D. A. G.
Two cases of acute lymphoblastic leukaemia (A.L.L.) of T-cell type are reported. Clinically they were characterized by very high peripheral blood blast cell counts at presentation, the early...
Prolonged remission maintenance in acute myeloid leukaemia.
Spiers, A S, Goldman, J M, Catovsky, D, Costello, C, Galton, D A, Pitcher, C S
Twenty-five patients with acute myeloid leukaemia were treated with three quadruple drug combinations in predetermined rotation: TRAP (thioguanine, daunorubicin, cytarabine, prednisolone); COAP...
Chronic Granulocytic Leukaemia: Effect of Elective Splenectomy on the Course of Disease
Spiers, A. S. D., Baikie, A. G., Galton, D. A. G., Richards, H. G. H., Wiltshaw, E., Goldman, J. M., ...
Conventional treatment by drugs or irradiation produces little prolongation of life in patients with chronic granulocytic leukaemia (C.G.L.) because the onset of metamorphosis of the disease from a...
Thromboembolic Complications in Myelomatosis
Catovsky, D., Ikoku, N. B., Pitney, W. R., Galton, D. A. G.
Fourteen cases of myelomatosis associated with major thromboembolic complications are reported. Six patients died of pulmonary embolism, seven had deep-vein thrombosis as a presenting symptom, and...
Familial Acute Myeloid Leukaemia with Acquired Pelger-Huët Anomaly and Aneuploidy of C Group
Kaur, Juginder, Catovsky, D., Valdimarsson, H., Jensson, O., Spiers, A. S. D.
All five members of one generation in an Icelandic family were affected by acute myeloid leukaemia or preleukaemia. Two sibs died of acute myeloid leukaemia and another of myelofibrosis associated...
Binucleated blast-cells in lymphocyte cultures from myelomatosis
Catovsky, D., Holt, P. J. L., Galton, D. A. G.
Binucleated blast cells were observed in phytohaemagglutinin (PHA) stimulated lymphocyte cultures of seventeen out of twenty-six cases of myelomatosis, in contrast to six out of sixteen normal...
In vitro activation of leukaemic B cells by interleukin-4 and antibodies to CD40.
Chronic lymphocytic leukaemia (CLL) B cells have the phenotype of mature, partially activated B cells, but are relatively resistant to stimulation through cell-surface receptors with agents such as...
Inhibition of T-lymphocyte colony formation by inhibitors of mitochondrial protein synthesis.
Foa, R, Zafar, M N, Catovsky, D
A double layer technique which requires an underlayer of peripheral blood leucocytes, in addition to phytohaemmagglutinin (PHA) in the overlayer, to obtain good T-lymphocyte colony formation, was...
Detection of cyclin D1 in B cell lymphoproliferative disorders by flow cytometry
Jain, P, Giustolisi, G M, Atkinson, S, Elnenaei, M O, Morilla, R, Owusu-Ankomah, K, ...
Aims: To describe and revise a flow cytometric assay for evaluating cyclin D1 overexpression in B cell lymphoproliferative disorders (B-LPDs).
Sah, S P, Matutes, E, Wotherspoon, A C, Morilla, R, Catovsky, D
Aims: To evaluate the diagnostic value of bone marrow aspirates, trephine biopsies (BMB), and flow cytometry (FC) in the assessment of bone marrow infiltration in chronic lymphoid disorders.
Thien, S L, Catovsky, D, Oscier, D, Goldman, J M, Van Der Reijden, H J, Melief, C J, ...
A 63 year old man with late onset hypogammaglobulinaemia is described. Splenectomy, carried out because of marked splenomegaly and pancytopenia, demonstrated marked T lymphocytic infiltration in the...
The ultrastructural characteristics of normal lymphocyte subpopulations, identified by monoclonal antibodies and visualized by a colloidal gold labelled anti-mouse IgG were analysed. Our study...
Evidence that T colony formation is a property of T mu (helper) lymphocytes.
Foa, R, Lauria, F, Catovsky, D
The T-colony-forming capacity of different T lymphocyte subsets was studied in normal peripheral blood. Unfractionated lymphocytes (after 'Lymphoprep' separation) gave rise to a mean of 150 +/- 27 ....
Zafar, M N, Pittman, S, Cherchi, M, Catovsky, D
CLL lymphocytes gave a low response upon stimulation with PHA or PWM in 3-day cultures. However, after treatment with neuraminidase-galactose oxidase (NGO), in the presence of PWM, CLL lymphocytes...
The effect of cyclosporin A on the formation of T lymphocyte colonies from human peripheral blood and bone marrow was tested using a double-layer technique. A moderate inhibition (27%) was observed...
T-lymphocyte colonies in normal blood, bone marrow and lymphoproliferative disorders.
The formation of T-lymphocyte colonies was studied in normal individuals and in different lymphoproliferative disorders, using the double layer technique of Lowenberg & de Zeeuw (1977). All normal...
Mouse RBC rosettes in chronic lymphocytic leukaemia: different expression in blood and tissues.
Mouse RBC (M) rosettes were investigated on lymphocytes from peripheral blood (PB) and various tissues in twenty patients with chronic lymphocytic leukaemia and one with follicular lymphoma. In all...
Melo, J V, Foroni, L, Brito-Babapulle, V, Luzzatto, L, Catovsky, D
We have studied the capacity of peripheral blood cells from 26 chronic B cell leukaemias to proliferate continuously in culture; 72 attempts to establish cell lines were made. The cells were treated...
Immunological reconstitution after bone marrow transplant with Campath-1 treated bone marrow.
Parreira, A, Smith, J, Hows, J M, Smithers, S A, Apperley, J, Rombos, Y, ...
Immunological reconstitution after allogeneic bone marrow transplant (BMT) was studied in 20 patients who received Campath-1 treated bone marrow. The peripheral blood lymphocyte phenotype was...
Polli, N, Matutes, E, Robinson, D, Catovsky, D
The morphological features of normal peripheral blood lymphocytes reactive with three monoclonal antibodies (MoAb) against natural killer (NK) cells, Leu7, OKM1 (CD11b) and Leu11 (CD16) and with two...
An unusual variant of T-CLL: evidence for the existence of a hitherto unrecognized T cell subset.
Moss, V E, Miedema, F, Matutes, E, Terpstra, F, Brownell, A, Brozovic, M, ...
A case of T-cell chronic lymphocytic leukaemia (T-CLL) with an unusual mature membrane phenotype: E+, CD3+, CD4+, CD8-, M1+, Leu-15+, Fc gamma+, is described. The cells were large granular...
Surface structure of normal and leukaemic lymphocytes. I. Effect of mitogens
Holt, P. J. L., Pal, S. G., Catovsky, D., Lewis, S. M.
Scanning electron microscopy has been used to examine the surface structure of normal and leukaemic lymphocytes and the effect of specific and non-specific mitogens on them. Both types of mitogens...
Airways obstruction associated with graft versus host disease after bone marrow transplantation.
Wyatt, S E, Nunn, P, Hows, J M, Yin, J, Hayes, M C, Catovsky, D, ...
Eight patients, five with chronic granulocytic leukaemia and three with severe aplastic anaemia, developed moderately severe airflow obstruction after allogeneic bone marrow transplantation. All...
Incomplete Reiter's syndrome following chemotherapy of acute myeloid leukaemia.
Dharmasena, F., Englert, H., Catovsky, D., Galton, D. A., Drysdale, H. C.
Reiter's syndrome and other reactive arthritides have been described following infection with various organisms although they can occur in unusual circumstances without an obvious infectious...
EPIC: an effective low toxicity regimen for relapsing lymphoma.
Hickish, T., Roldan, A., Cunningham, D., Mansi, J., Ashley, S., Nicolson, V., ...
We have treated 40 patients was relapsed or resistant lymphoma with the combination of Etoposide, Prednisolone, Ifosfamide and Cisplatin (EPIC). Complete response was obtained in 11 patients (28%)...
Fludarabine phosphate for the treatment of low grade lymphoid malignancy.
Whelan, J. S., Davis, C. L., Rule, S., Ranson, M., Smith, O. P., Mehta, A. B., ...
Thirty-four patients with previously treated, advanced, low grade NHL were treated with Fludarabine, a deamination-resistant analogue of adenosine arabinoside, at a dose of 25 mg m-2 intravenously,...
Deoxycoformycin in the treatment of mature T-cell leukaemias.
Dearden, C., Matutes, E., Catovsky, D.
We describe the results of treatment with 2'-deoxycoformycin (DCF) in 68 patients with post-thymic (mature) T-cell malignancies. These included: prolymphocytic leukaemia (T-PLL), 31, HTLV-1 + adult...
Marcus, R. E., Catovsky, D., Johnson, S. A., Gregory, W. M., Talavera, J. G., Goldman, J. M., ...
Between 1974 and 1984 69 adults with acute lymphoblastic leukaemia (ALL) were treated with two different protocols. Fifty-four (78%) of the patients entered complete remission (CR); 27 of these then...
Lymphocyte Transformation in Immunoproliferative Disorders
Catovsky, D., Holt, P. J. L., Galton, D. A. G.
Lymphocyte transformation with phytohaemagglutinin (PHA) was studied in 30 patients with immunoproliferative disorders (lymphoproliferative and plasma cell disorders).
Ng, M, Waters, J, Cunningham, D, Chau, I, Horwich, A, Hill, M, ...
There is currently no standard salvage chemotherapy regimen in relapsed and refractory lymphoma. Gemcitabine is a novel nucleoside analogue, which acts synergistically with cisplatin both in vitro...