D. Fasshauer

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis. (2010)

Walter, A. M., Wiederhold, K., Bruns, D., Fasshauer, D., Soerensen, J. B.

Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi. (2009)

Kienle, N., Kloepper, T. H., Fasshauer, D.

Is assembly of the SNARE complex enough to fuel membrane fusion? (2009)

Wiederhold, K., Fasshauer, D.

Differences in the SNARE evolution of fungi and metazoa. (2009)

Kienle, N., Kloepper, T. H., Fasshauer, D.

A Conserved Membrane Attachment Site in alpha-SNAP Facilitates N-Ethylmaleimide-sensitive Factor (NSF)-driven SNARE Complex Disassembly. (2009)

Winter, U., Chen, X., Fasshauer, D.

Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion. (2009)

Domanska, M. K., Kiessling, V., Stein, A., Fasshauer, D., Tamm, L. K.

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. (2009)

Radhakrishnan, A., Stein, A., Jahn, R., Fasshauer, D.

A novel site of action for α -SNAP in the SNARE conformational cycle controlling membrane fusion. (2008)

Barszczewski, M., Chua, J., Stein, A., Winter, U., Heintzmann, R., Zilly, F. E., ...

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. (2008)

Burkhardt, P., Hattendorf, D. A., Weis, W. I., Fasshauer, D.

Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes. (2008)

Bar-On, D., Winter, U., Nachliel, E., Gutman, M., Fasshauer, D., Lang, T., ...

SNAREing the basis of multicellularity: consequences of protein family expansion during evolution. (2008)

Kloepper, T. H., Kienle, N., Fasshauer, D.

Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies (2007)

Zwilling, D., Cypionka, A., Pohl, W., Fasshauer, D., Walla, P. J., Wahl, M. C., ...

Budding insights on cell polarity (2007)

Fasshauer, D., Jahn, R.

Determinants of synaptobrevin regulation in membranes (2007)

Siddiqui, T. J., Vites, O., Stein, A., Heintzmann, R., Jahn, R., Fasshauer, D.

An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system (2007)

Kloepper, T. H., Kienle, N., Fasshauer, D.

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids (2007)

Stein, A., Radhakrishnan, A., Riedel, D., Fasshauer, D., Jahn, R.

Thermodynamic studies on SNARE complex assembly. (2007)

Fasshauer, D., Wiederhold, K.

Disrupting SNARE complexity - biophysical investigations of NSF/SNAP-mediated SNARE complex disassembly. (2007)

Winter, U., Fasshauer, D.

Studies on the molecular mechanism of the acceleration of SNARE-mediated membrane fusion by synaptotagmin 1. (2007)

Stein, A., Radhakrishnan, A., Fasshauer, D.

A common binding mode for Sec1/munc18 proteins. (2007)

Burghardt, P., Fasshauer, D.

Sequential N-to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. (2006)

Soerensen, J. B., Wiederhold, K., Mueller, E. M., Milosevic, I., Nagy, G., De Groot, B. L., ...

Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. (2006)

Holt, M., Varoqueaux, F., Wiederhold, K., Takamori, S., Urlaub, H., Fasshauer, D., ...

N- to C-terminal SNARE complex assembly promotes rapid membrane fusion (2006)

Pobbati, A., Stein, A., Fasshauer, D.

Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain (2005)

Nagy, G., Milosevic, I., Fasshauer, D., Mueller, E. M., De Groot, B. L., Lang, T., ...

A transient syntaxin/SNAP-25 interaction serves as ready-available binding site for synaptobrevin (2005)

Fasshauer, D.

Biophysical investigations of synaptotagmin-SNARE interaction (2005)

Radhakrishnan, A., Fasshauer, D., Wiederhold, K., Jahn, R.

A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly (2004)

Fasshauer, D., Margittai, M.

Structural basis for the inhibitory role of tomosyn in exocytosis (2004)

Pobbati, A., Razeto, A., Boeddener, M., Becker, S., Fasshauer, D.

Structural insights into the SNARE mechanism (2003)

Fasshauer, D.

The Habc domain and the SNARE core complex are connected by a highly flexible linker (2003)

Margittai, M., Fasshauer, D., Jahn, R., Langen, R.

The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis (2003)

Hatsuzawa, K., Lang, T., Fasshauer, D., Bruns, D., Jahn, R.

Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1 (2003)

Margittai, M., Widengren, J., Schweinberger, E., Schroder, G., Felekyan, S., Haustein, E., ...

Crystal Structure of a Complex Between Human Spliceosomal Cyclophilin H and a U4/U6 snRNP-60K Peptide (2003)

Reidt, U., Wahl, M. C., Fasshauer, D., Horowitz, D., Luehrmann, R., Ficner, R.

SNARE assembly and disassembly exhibit a pronounced hysteresis (2002)

Fasshauer, D., Antonin, W., Subramaniam, V., Jahn, R.

SNARE proteins are essential for intracellular membrane fusion of eukaryotes. Their assembly into stable four-helix bundles bridges membranes and may provide the energy for initiating membrane...

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs (2002)

Antonin, W., Fasshauer, D., Becker, S., Jahn, R., Schneider, T. R.

SNARE proteins are crucial for intracellular membrane fusion in all eukaryotes. These proteins assemble into tight complexes that connect membranes and may induce fusion. The crystal structure of the...

Single molecule FRET reveals an equilibrium between a closed and an open conformation of syntaxin 1 (2002)

Margittai, M., Schweinberger, E., Widengren, J., Fasshauer, D., Jahn, R., Schroeder, G., ...

Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis (2002)

Pabst, S., Margittai, M., Vainius, D., Langen, R., Jahn, R., Fasshauer, D.

The Ca2+ -triggered release of neurotransmitters is mediated by fusion of synaptic vesicles with the plasma membrane. The molecular machinery that translates the Ca2+ signal into exocytosis is only...

Mechanisms of membrane fusion. (2001)

Fasshauer, D., Schuette, C. G., Jahn, R.

Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling. (2001)

Margittai, M., Fasshauer, D., Pabst, S., Jahn, R., Langen, R.

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. (2000)

Antonin, W., Holroyd, C., Fasshauer, D., Pabst, S., Fischer Von Mollard, G., Jahn, R.

Mechanismen intrazellulärer Membranfusion. (2000)

Fasshauer, D., Jahn, R.

Selective interaction of complexin with the neuronal SNARE complex: Determination of the binding regions. (2000)

Pabst, S., Hazzard, J. W., Antonin, W., Suedhof, T. C., Jahn, R., Rizo, J., ...

Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. (1999)

Fasshauer, D., Antonin, W., Margittai, M., Pabst, S., Jahn, R.

Identification of a minimal core of the synaptic SNARE-complex sufficient for reversible assembly and disassembly. (1998)

Fasshauer, D., Eliason, W. K., Bruenger, A. T., Jahn, R.

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. (1998)

Fasshauer, D., Sutton, B., Bruenger, A. T., Jahn, R.

Crystal structure of a core synaptic fusion complex at 2.4 Å resolution. (1998)

Sutton, B., Fasshauer, D., Jahn, R., Bruenger, A. T.

Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1

Margittai, M., Widengren, J., Schweinberger, E., Schröder, G. F., Felekyan, S., Haustein, E., ...

Protein conformational transitions form the molecular basis of many cellular processes, such as signal transduction and membrane traffic. However, in many cases, little is known about their...

Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1

Margittai, M., Widengren, J., Schweinberger, E., Schröder, G. F., Felekyan, S., Haustein, E., ...

Protein conformational transitions form the molecular basis of many cellular processes, such as signal transduction and membrane traffic. However, in many cases, little is known about their...