Aging of human sebocytes in vitro induced by exposure to a defined hormone environment (2006)
Makrantonaki, E., Adjaye, J., Herwig, R., Brink, T. C., Groth, D., Hultschig, C., ...
Expression of recombinant tissue factor pathway inhibitor in an insect cell system (2006)
Ellery, P, Chandler, D, Paxman, A, Groth, D, Broze, G, Adams, MJ
Hammond, E. L., Lymbery, A. J., Martin, G. B., Groth, D., Wetherall, J. D.
The emu (Dromaius novaehollandiae) occupies most regions of the Australian continent and in recent times has been farmed for meat, oil, and leather. Very little is known about the genetic structure...
Proefschrift Berlijn.
Carlson, G A, Ebeling, C, Yang, S L, Telling, G, Torchia, M, Groth, D, ...
Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To investigate prion diversity, we inoculated...
Hsiao, K K, Groth, D, Scott, M, Yang, S L, Serban, H, Rapp, D, ...
Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from...
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
Prusiner, S B, Groth, D, Serban, A, Stahl, N, Gabizon, R
A wealth of experimental evidence argues that infectious prions are composed largely, if not entirely, of the scrapie isoform of the prion protein. We attempted to restore scrapie infectivity after...
DeArmond, S J, Yang, S L, Lee, A, Bowler, R, Taraboulos, A, Groth, D, ...
To investigate the molecular basis of prion diversity, we inoculated transgenic mice expressing the Syrian hamster prion protein (PrP) with three distinct prion isolates. We compared the three...
Prusiner, S B, Groth, D, Serban, A, Koehler, R, Foster, D, Torchia, M, ...
Mice, homozygous for prion protein (PrP) gene ablation (Prn-p0/0), develop normally and remain well > 500 days after inoculation with murine scrapie prions. In contrast, wild-type mice developed...
Pan, K M, Baldwin, M, Nguyen, J, Gasset, M, Serban, A, Groth, D, ...
Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc from the cellular prion protein (PrPC) is a post-translational process,...
Riesner, D, Kellings, K, Post, K, Wille, H, Serban, H, Groth, D, ...
An abnormal isoform of the prion protein (PrP) designated PrPSc is the major, or possibly the only, component of infectious prions. Structural studies of PrPSc have been impeded by its lack of...
Failure to transmit disease from gray tremor mutant mice.
Carlson, G A, Banks, S, Lund, D, Reichert, C, Groth, D, Torchia, M, ...
Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense...
Propagation of prion strains through specific conformers of the prion protein.
Scott, M R, Groth, D, Tatzelt, J, Torchia, M, Tremblay, P, DeArmond, S J, ...
Two prion strains with identical incubation periods in mice exhibited distinct incubation periods and different neuropathological profiles upon serial transmission to transgenic mice expressing...
Immunoaffinity purification and neutralization of scrapie prion infectivity.
Gabizon, R, McKinley, M P, Groth, D, Prusiner, S B
Prions are unusual infectious pathogens causing scrapie of sheep and goats as well as Creutzfeldt-Jakob disease of humans. Biochemical and genetic studies contend that the scrapie isoform of the...
Carlson, G A, Ebeling, C, Yang, S L, Telling, G, Torchia, M, Groth, D, ...
Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To investigate prion diversity, we inoculated...
Hsiao, K K, Groth, D, Scott, M, Yang, S L, Serban, H, Rapp, D, ...
Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from...
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
Prusiner, S B, Groth, D, Serban, A, Stahl, N, Gabizon, R
A wealth of experimental evidence argues that infectious prions are composed largely, if not entirely, of the scrapie isoform of the prion protein. We attempted to restore scrapie infectivity after...
DeArmond, S J, Yang, S L, Lee, A, Bowler, R, Taraboulos, A, Groth, D, ...
To investigate the molecular basis of prion diversity, we inoculated transgenic mice expressing the Syrian hamster prion protein (PrP) with three distinct prion isolates. We compared the three...
Prusiner, S B, Groth, D, Serban, A, Koehler, R, Foster, D, Torchia, M, ...
Mice, homozygous for prion protein (PrP) gene ablation (Prn-p0/0), develop normally and remain well > 500 days after inoculation with murine scrapie prions. In contrast, wild-type mice developed...
Pan, K M, Baldwin, M, Nguyen, J, Gasset, M, Serban, A, Groth, D, ...
Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc from the cellular prion protein (PrPC) is a post-translational process,...
Riesner, D, Kellings, K, Post, K, Wille, H, Serban, H, Groth, D, ...
An abnormal isoform of the prion protein (PrP) designated PrPSc is the major, or possibly the only, component of infectious prions. Structural studies of PrPSc have been impeded by its lack of...
Failure to transmit disease from gray tremor mutant mice.
Carlson, G A, Banks, S, Lund, D, Reichert, C, Groth, D, Torchia, M, ...
Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense...
Propagation of prion strains through specific conformers of the prion protein.
Scott, M R, Groth, D, Tatzelt, J, Torchia, M, Tremblay, P, DeArmond, S J, ...
Two prion strains with identical incubation periods in mice exhibited distinct incubation periods and different neuropathological profiles upon serial transmission to transgenic mice expressing...
Immunoaffinity purification and neutralization of scrapie prion infectivity.
Gabizon, R, McKinley, M P, Groth, D, Prusiner, S B
Prions are unusual infectious pathogens causing scrapie of sheep and goats as well as Creutzfeldt-Jakob disease of humans. Biochemical and genetic studies contend that the scrapie isoform of the...