Wireless capsule endoscopy in the investigation of intestinal Behcet's syndrome (2008)
Hamdulay, S. S., Cheent, K., Ghosh, C., Stocks, J., Ghosh, S., Haskard, D. O.
Objective. Intestinal Behçet's Syndrome (BS) is a difficult diagnosis to establish. We describe the use of wireless capsule endoscopy (WCE) in the investigation of 11 patients with suspected...
Planning your research training (2005)
Cope, A. P., Brennan, F. M., Hill Gaston, J. S., Haskard, D. O.
OP20. IMAGING ENDOTHELIAL ACTIVATION IN INFLAMMATION (2005)
Despite the important role that endothelial activation plays during inflammatory responses, molecular changes in endothelium are relatively inaccessible to clinical investigation. E-selectin (CD62E,...
Planning your research training (2005)
Cope, A. P., Brennan, F. M., Hill Gaston, J. S., Haskard, D. O.
Planning your research training (2005)
Cope, A. P., Brennan, F. M., Hill Gaston, J. S., Haskard, D. O.
Ahmad,S.R., Lidington,E.A., Ohta,R., Okada,N., Robson,M.G., Davies,K., ...
Marshall, D., Dangerfield, J. P., Bhatia, V. K., Larbi, K. Y., Nourshargh, S., Haskard, D. O.
Objective. Endothelial activation and dysfunctional leucocyte-endothelial interactions are thought to play key roles in the pathogenesis of systemic lupus erythematosus (SLE). The object of this...
Marshall, D., Dangerfield, J. P., Bhatia, V. K., Larbi, K. Y., Nourshargh, S., Haskard, D. O.
Objective. Endothelial activation and dysfunctional leucocyte–endothelial interactions are thought to play key roles in the pathogenesis of systemic lupus erythematosus (SLE). The object...
Marshall, D., Dangerfield, J. P., Bhatia, V. K., Larbi, K. Y., Nourshargh, S., Haskard, D. O.
Objective. Endothelial activation and dysfunctional leucocyte-endothelial interactions are thought to play key roles in the pathogenesis of systemic lupus erythematosus (SLE). The object of this...
Jamar, F., Houssiau, F. A., Devogelaer, J.-P., Chapman, P. T., Haskard, D. O., Beaujean, V., ...
Objective. We previously described a novel radiolabelled monoclonal antibody (1.2B6), which reacts with porcine E‐selectin, for targeting activated endothelium as a means of...
Limited endothelial E- and P-selectin expression in MRL/lpr lupus-prone mice (2001)
Harari, O. A., Marshall, D., McHale, J. F., Ahmed, S., Haskard, D. O.
Objective. Inflammation in MRL/lpr mice may involve dysfunctional leucocyte–endothelial cell (EC) interactions. Previously, we have shown that intercellular adhesion molecule 1...
CHAPMAN, P. T., JAMAR, F., HARRISON, A. A., SCHOFIELD, J. B., PETERS, A. M., BINNS, R. M., ...
The self-limiting response to urate crystals allows the exploration of events involved in both the onset and resolution of gout. Using i.v. injected radiolabelled anti-E-selectin monoclonal antibody...
SERIAL CIRCULATING ADHESION MOLECULE LEVELS REFLECT DISEASE SEVERITY IN SYSTEMIC SCLEROSIS (1995)
DENTON, C. P., BICKERSTAFF, M. C. M., SHIWEN, X., CARULLI, M. T., HASKARD, D. O., DUBOIS, R. M., ...
Microvascular damage occurs in systemic sclerosis (SSc) and is associated with increased expression of endothelial adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular...
Leukocyte adhesion molecules (1995)
The last few years have seen an enormous expansion of knowledge regarding the role of cell surface adhesion molecules in biological processes. This article discusses the contribution that adhesion...
Expression of VCAM-1 in the Normal and Diseased Kidney (1991)
Seron, D., Cameron, J. S., Haskard, D. O.
We have conducted an immunocytochemical analysis to investigate the presence of the recently described vascular cell adhesion molecule-1 (VCAM-1) in human kidney, using the anti-VCAM-1 monoclonal...
A patient with typical diffuse idiopathic skeletal hyperostosis and characteristic new bone formation around the elbows exhibited bilateral ulnar nerve entrapment at these sites as well as median...
KIRWAN, J. R., HASKARD, D. O., HIGGENS, C. S.
Twenty-seven patients requiring bilateral knee aspiration showed no overall preference for or against the use of subcutaneous lignocaine during knee aspiration. The trial result attained a predefined...
Montefort, S, Gratziou, C, Goulding, D, Polosa, R, Haskard, D O, Howarth, P H, ...
We have examined the mucosal changes occurring in bronchial biopsies from six atopic asthmatics 5-6 h after local endobronchial allergen challenge and compared them with biopsies from...
Vessel associated adhesion molecules in normal skin and acute graft-versus-host disease.
Norton, J, Sloane, J P, Al-Saffar, N, Haskard, D O
Immunohistological staining of skin from normal donors and bone marrow transplant recipients was undertaken using antibodies to two vessel associated adhesion molecules, endothelial leucocyte...
Burrows, N P, Molina, F A, Terenghi, G, Clark, P K, Haskard, D O, Polak, J M, ...
AIMS--To compare the expression of the cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), ELAM-1 (E-selectin), and vascular cell adhesion molecule-1 (VCAM-1) in cutaneous...
Montefort, S, Gratziou, C, Goulding, D, Polosa, R, Haskard, D O, Howarth, P H, ...
We have examined the mucosal changes occurring in bronchial biopsies from six atopic asthmatics 5-6 h after local endobronchial allergen challenge and compared them with biopsies from...
Vessel associated adhesion molecules in normal skin and acute graft-versus-host disease.
Norton, J, Sloane, J P, Al-Saffar, N, Haskard, D O
Immunohistological staining of skin from normal donors and bone marrow transplant recipients was undertaken using antibodies to two vessel associated adhesion molecules, endothelial leucocyte...
Burrows, N P, Molina, F A, Terenghi, G, Clark, P K, Haskard, D O, Polak, J M, ...
AIMS--To compare the expression of the cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), ELAM-1 (E-selectin), and vascular cell adhesion molecule-1 (VCAM-1) in cutaneous...
Porcine E-selectin: cloning and functional characterization.
Tsang, Y T, Stephens, P E, Licence, S T, Haskard, D O, Binns, R M, Robinson, M K
E-selectin, a member of the selectin family, is believed to play an important role in mediating the initial adhesive events between leucocytes and the endothelium during inflammation. A monoclonal...
Mechanisms of lymphocyte adhesion to endothelial cells: studies using a LFA-1-deficient cell line.
Haskard, D O, Strobel, S, Thornhill, M, Pitzalis, C, Levinsky, R J
In order to investigate the role of lymphocyte function-associated antigen 1 (LFA-1) in lymphocyte adhesion to endothelial cells (EC), we have studied the adhesion of a LFA-1-deficient lymphoblastoid...
T cells and neutrophils exhibit differential adhesion to cytokine-stimulated endothelial cells.
Thornhill, M H, Kyan-Aung, U, Lee, T H, Haskard, D O
In vitro adhesion assays were used to directly compare the adhesion of polymorphonuclear leucocytes (PMN) and T cells to endothelial cells (EC). PMN exhibited lower binding to unstimulated EC than T...
Woolley, S T, Whyte, A, Licence, S T, Haskard, D O, Wooding, F B, Binns, R M
We have developed a novel subcutaneous sponge matrix model in major histocompatibility complex (MHC) homozygous SLAb/b inbred pigs to study lymphocyte-endothelial cell interactions during...
Spontaneous rupture of the spleen in rheumatoid arthritis.
Haskard, D O, Higgens, C S, Temple, L N, Currey, H L
Two patients with rheumatoid arthritis without splenomegaly or Felty's syndrome developed spontaneous rupture of the spleen. The histological appearance was consistent with involvement of the splenic...
Successful treatment of dermatomyositis complicated by ventilatory failure.
A case is reported in which ventilatory failure complicating dermatomyositis was successfully managed with artificial ventilation for 18 days while remission was achieved with methotrexate and...
Factors associated with joint mobility in an adolescent population.
Silman, A J, Day, S J, Haskard, D O
Fixed torque devices were used to measure joint mobility at three sites in 364 adolescents including 39 families with at least two siblings. Increasing age and being male were associated with reduced...
Pallis, M, Robson, D K, Haskard, D O, Powell, R J
OBJECTIVE--To investigate the pathophysiology of perivascular mononuclear cell infiltrates observed in skeletal muscle from patients with systemic lupus erythematosus (SLE)....
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.
Poston, R. N., Haskard, D. O., Coucher, J. R., Gall, N. P., Johnson-Tidey, R. R.
Immunohistochemistry of human atherosclerotic arteries demonstrates expression of the intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, macrophages, and smooth muscle cells of the...
Day, J R S, Malik, I S, Weerasinghe, A, Poullis, M, Nadra, I, Haskard, D O, ...
Objective: To study the effect of unfractionated heparin (UFH) versus low molecular weight heparin (LMWH) in combination with glycoprotein (Gp) IIb/IIIa blockers on platelet activation and...
Circulating adhesion molecules in tuberculosis.
Lai, C K, Wong, K C, Chan, C H, Ho, S S, Chung, S Y, Haskard, D O, ...
Leucocyte-endothelial adhesion molecules have been implicated in the pathogenesis of inflammatory diseases. To evaluate their role as markers of disease activity in tuberculosis, we have used an...
Differential upregulation of intercellular adhesion molecule-1 in coeliac disease.
Sturgess, R P, Macartney, J C, Makgoba, M W, Hung, C H, Haskard, D O, Ciclitira, P J
The expression of intercellular adhesion molecule-1 (ICAM-1) was studied on peroral jejunal biopsies from patients with coeliac disease. The biopsies from untreated patients exhibited greater...
Expression of adhesion molecules in human intestinal graft-versus-host disease.
Norton, J, Sloane, J P, Al-Saffar, N, Haskard, D O
The distribution of three cellular adhesion molecules, ICAM-1, ELAM-1 and VCAM-1, was studied in normal rectal mucosa and in graft-versus-host disease (GvHD) using immunohistological and morphometric...
Beynon, H L, Haskard, D O, Davies, K A, Haroutunian, R, Walport, M J
The deposition of circulating immune reactants in blood vessels, an important event in the pathogenesis of certain types of vasculitis, requires an increase in permeability in the endothelial...
Wellicome, S M, Kapahi, P, Mason, J C, Lebranchu, Y, Yarwood, H, Haskard, D O
We have developed a panel of MoAbs against four separate but overlapping epitopes on endothelial cell (EC) vascular cell adhesion molecule-1 (VCAM-1). Two of the MoAbs (1G11 and 1E5) inhibited T cell...
Haskard, D O, Gul, V, Morgan, A, Kataaha, P, Staines, N A, Archer, J R
Hybridization of peripheral blood lymphocytes from patients with rheumatoid arthritis has yielded 14 monoclonal antibodies which react with cultured human epithelial cells. Immunofluorescence...
Human gamma interferon increases the binding of T lymphocytes to endothelial cells.
Yu, C L, Haskard, D O, Cavender, D, Johnson, A R, Ziff, M
Binding of lymphocytes to human umbilical vein endothelial cells (EC) was quantitated by measuring adhesion of 51Cr labelled lymphocytes to endothelial cell monolayers and rosette formation between...
Wahid, S, Blades, M C, De Lord, D, Brown, I, Blake, G, Yanni, G, ...
Adhesion mechanisms play a major role in the recruitment of peripheral blood lymphocytes (PBL) which characteristically infiltrate rheumatoid arthritis (RA) synovium and other chronically inflamed...
Hepburn, A L, Mason, J C, Wang, S, Shepherd, C J, Florey, O, Haskard, D O, ...
Abnormal clearance by the mononuclear phagocytic system of immune complexes (IC) is important in the pathogenesis of systemic lupus erythematosus (SLE). We have developed an in vitro model to...