David A. Lathrop

Prevention of some hypothermia induced electromechanical changes by calcium channel blockade (1994)

Bjørnstad, Hanne, Lathrop, David A, Refsum, Helge

Objective: Cooling induces electromechanical changes in the heart. The aim of the study was to examine how the calcium channel blocker, nisoldipine (NIS), altered these changes compared to those...

Effects of temperature on cycle length dependent changes and restitution of action potential duration in guinea pig ventricular muscle (1993)

Bjørnstad, Hanne, Tande, Pål M, Lathrop, David A, Refsum, Helge

Objective: The aim was to investigate the effects of temperature on cycle length dependent changes of action potential duration and on restitution of action potential duration. Methods: Guinea pig...

Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes (1992)

Yang, Tao, Tande, Pål M, Lathrop, David A, Refsum, Helge

Objective: The aim was to examine the electromechanical effects of dofetilide, a new class III antiarrhythmic agent, in isolated guinea pig ventricular muscle during hypoxia. Methods: Hypoxia was...

Pharmacological block of the slow component of the outward delayed rectifier current (IKs) fails to lengthen rabbit ventricular muscle QTc and action potential duration

Lengyel, Csaba, Iost, Norbert, Virág, László, Varró, András, Lathrop, David A, Papp, Julius Gy

The effects of IKs block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to those of E-4031, a recognized IKr blocker....

The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization

Varró, András, Baláti, Beáta, Iost, Norbert, Takács, János, Virág, László, Lathrop, David A, ...

The relative contributions of the rapid and slow components of the delayed rectifier potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration were compared in...