David E. Nelson

Cigarette Smoking Status and the Association between Media Use and Overweight and Obesity (2007)

Yore, Michelle M., Fulton, Janet E., Nelson, David E., Kohl, Harold W.

For biologic and behavioral reasons, cigarette smokers weigh less than nonsmokers. Thus, cigarette smoking may modify the association between media use and obesity. The authors examined whether the...

Are Smokers Only Using Cigarettes? Exploring Current Polytobacco Use Among an Adult Population (2007)

Bombard, Jennifer M., Pederson, Linda L., Nelson, David E., Malarcher, Ann M.

Background: The primary focus of tobacco prevention and cessation interventions has been on cigarette smoking. Polytobacco use (the concurrent use of cigarettes and one or more other tobacco...

Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage (2006)

Barker, Catherine R., McNamara, Anne V., Rackstraw, Stephen A., Nelson, David E., White, Mike R., Watson, Alastair J. M., ...

Topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and meiosis and is a highly attractive target for chemotherapeutic agents. We have identified...

Confirmation, Explanation, and Logical Strength (1996)

Nelson, David E.

Van Fraassen argues that explanatory power cannot be a conformational virtue. In this paper I will show that informational features of scientific theories can be positively relevant to their levels...

Escherichia coli Mutants Lacking All Possible Combinations of Eight Penicillin Binding Proteins: Viability, Characteristics, and Implications for Peptidoglycan Synthesis

Denome, Sylvia A., Elf, Pamela K., Henderson, Thomas A., Nelson, David E., Young, Kevin D.

The penicillin binding proteins (PBPs) synthesize and remodel peptidoglycan, the structural component of the bacterial cell wall. Much is known about the biochemistry of these proteins, but little is...

Penicillin Binding Protein 5 Affects Cell Diameter, Contour, and Morphology of Escherichia coli

Nelson, David E., Young, Kevin D.

Although general physiological functions have been ascribed to the high-molecular-weight penicillin binding proteins (PBPs) of Escherichia coli, the low-molecular-weight PBPs have no well-defined...

Contributions of PBP 5 and dd-Carboxypeptidase Penicillin Binding Proteins to Maintenance of Cell Shape in Escherichia coli

Nelson, David E., Young, Kevin D.

Escherichia coli has 12 recognized penicillin binding proteins (PBPs), four of which (PBPs 4, 5, and 6 and DacD) have dd-carboxypeptidase activity. Although the enzymology of the dd-carboxypeptidases...

Reconstruction of Escherichia coli mrcA (PBP 1a) Mutants Lacking Multiple Combinations of Penicillin Binding Proteins

Meberg, Bernadette M., Sailer, Frances C., Nelson, David E., Young, Kevin D.

Previously, we constructed a set of mutants from which eight penicillin binding protein (PBP) genes were deleted in 192 combinations from Escherichia coli (S. A. Denome, P. K. Elf, T. A. Henderson,...

Contribution of Membrane-Binding and Enzymatic Domains of Penicillin Binding Protein 5 to Maintenance of Uniform Cellular Morphology of Escherichia coli

Nelson, David E., Ghosh, Anindya S., Paulson, Avery L., Young, Kevin D.

Four low-molecular-weight penicillin binding proteins (LMW PBPs) of Escherichia coli are closely related and have similar dd-carboxypeptidase activities (PBPs 4, 5, and 6 and DacD). However, only...

Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation

Belland, Robert J., Nelson, David E., Virok, Dezso, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, ...

Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role...

Chlamydial Infection Induces Pathobiotype-Specific Protein Tyrosine Phosphorylation in Epithelial Cells

Virok, Dezso P., Nelson, David E., Whitmire, William M., Crane, Deborah D., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are strict obligate intracellular pathogens that exhibit marked differences in host range and tissue tropism despite sharing a remarkable level of genomic synteny....

Chlamydial IFN-γ immune evasion is linked to host infection tropism

Nelson, David E., Virok, Dezso P., Wood, Heidi, Roshick, Christine, Johnson, Raymond M., Whitmire, William M., ...

Chlamydiae are obligate intracellular pathogens that can exhibit a broad host range in infection tropism despite maintaining near genomic identity. Here, we have investigated the molecular basis for...

Inhibition of Chlamydiae by Primary Alcohols Correlates with the Strain-Specific Complement of Plasticity Zone Phospholipase D Genes

Nelson, David E., Crane, Deborah D., Taylor, Lacey D., Dorward, David W., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are obligate intracellular pathogens that have a unique biphasic developmental cycle and interactions with host cells. Many genes that dictate host infection tropism...

Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage

Barker, Catherine R., McNamara, Anne V., Rackstraw, Stephen A., Nelson, David E., White, Mike R., Watson, Alastair J. M., ...

Topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and meiosis and is a highly attractive target for chemotherapeutic agents. We have identified...

A Comparison of National Estimates From the National Health Interview Survey and the Behavioral Risk Factor Surveillance System

Nelson, David E., Powell-Griner, Eve, Town, Machell, Kovar, Mary Grace

Objectives. The purpose of this study was to compare national estimates from the National Health Interview Survey (NHIS) and the Behavioral Risk Factor Surveillance System (BRFSS).

Escherichia coli Mutants Lacking All Possible Combinations of Eight Penicillin Binding Proteins: Viability, Characteristics, and Implications for Peptidoglycan Synthesis

Denome, Sylvia A., Elf, Pamela K., Henderson, Thomas A., Nelson, David E., Young, Kevin D.

The penicillin binding proteins (PBPs) synthesize and remodel peptidoglycan, the structural component of the bacterial cell wall. Much is known about the biochemistry of these proteins, but little is...

Penicillin Binding Protein 5 Affects Cell Diameter, Contour, and Morphology of Escherichia coli

Nelson, David E., Young, Kevin D.

Although general physiological functions have been ascribed to the high-molecular-weight penicillin binding proteins (PBPs) of Escherichia coli, the low-molecular-weight PBPs have no well-defined...

Contributions of PBP 5 and dd-Carboxypeptidase Penicillin Binding Proteins to Maintenance of Cell Shape in Escherichia coli

Nelson, David E., Young, Kevin D.

Escherichia coli has 12 recognized penicillin binding proteins (PBPs), four of which (PBPs 4, 5, and 6 and DacD) have dd-carboxypeptidase activity. Although the enzymology of the dd-carboxypeptidases...

Reconstruction of Escherichia coli mrcA (PBP 1a) Mutants Lacking Multiple Combinations of Penicillin Binding Proteins

Meberg, Bernadette M., Sailer, Frances C., Nelson, David E., Young, Kevin D.

Previously, we constructed a set of mutants from which eight penicillin binding protein (PBP) genes were deleted in 192 combinations from Escherichia coli (S. A. Denome, P. K. Elf, T. A. Henderson,...

Contribution of Membrane-Binding and Enzymatic Domains of Penicillin Binding Protein 5 to Maintenance of Uniform Cellular Morphology of Escherichia coli

Nelson, David E., Ghosh, Anindya S., Paulson, Avery L., Young, Kevin D.

Four low-molecular-weight penicillin binding proteins (LMW PBPs) of Escherichia coli are closely related and have similar dd-carboxypeptidase activities (PBPs 4, 5, and 6 and DacD). However, only...

Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation

Belland, Robert J., Nelson, David E., Virok, Dezso, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, ...

Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role...

Chlamydial Infection Induces Pathobiotype-Specific Protein Tyrosine Phosphorylation in Epithelial Cells

Virok, Dezso P., Nelson, David E., Whitmire, William M., Crane, Deborah D., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are strict obligate intracellular pathogens that exhibit marked differences in host range and tissue tropism despite sharing a remarkable level of genomic synteny....

Chlamydial IFN-γ immune evasion is linked to host infection tropism

Nelson, David E., Virok, Dezso P., Wood, Heidi, Roshick, Christine, Johnson, Raymond M., Whitmire, William M., ...

Chlamydiae are obligate intracellular pathogens that can exhibit a broad host range in infection tropism despite maintaining near genomic identity. Here, we have investigated the molecular basis for...

Inhibition of Chlamydiae by Primary Alcohols Correlates with the Strain-Specific Complement of Plasticity Zone Phospholipase D Genes

Nelson, David E., Crane, Deborah D., Taylor, Lacey D., Dorward, David W., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are obligate intracellular pathogens that have a unique biphasic developmental cycle and interactions with host cells. Many genes that dictate host infection tropism...

Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage

Barker, Catherine R., McNamara, Anne V., Rackstraw, Stephen A., Nelson, David E., White, Mike R., Watson, Alastair J. M., ...

Topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and meiosis and is a highly attractive target for chemotherapeutic agents. We have identified...

A Comparison of National Estimates From the National Health Interview Survey and the Behavioral Risk Factor Surveillance System

Nelson, David E., Powell-Griner, Eve, Town, Machell, Kovar, Mary Grace

Objectives. The purpose of this study was to compare national estimates from the National Health Interview Survey (NHIS) and the Behavioral Risk Factor Surveillance System (BRFSS).

Automated tracking of gene expression in individual cells and cell compartments

Shen, Hailin, Nelson, Glyn, Nelson, David E, Kennedy, Stephnie, Spiller, David G, Griffiths, Tony, ...

Many intracellular signal transduction processes involve the reversible translocation from the cytoplasm to the nucleus of transcription factors. The advent of fluorescently tagged protein...

Trends in Smokeless Tobacco Use Among Adults and Adolescents in the United States

Nelson, David E., Mowery, Paul, Tomar, Scott, Marcus, Stephen, Giovino, Gary, Zhao, Luhua

Objectives. Smokeless tobacco has many adverse health effects. We analyzed long-term national trends in smokeless tobacco use.

Embryo fossilization is a biological process mediated by microbial biofilms

Raff, Elizabeth C., Schollaert, Kaila L., Nelson, David E., Donoghue, Philip C. J., Thomas, Ceri-Wyn, Turner, F. Rudolf, ...

Fossilized embryos with extraordinary cellular preservation appear in the Late Neoproterozoic and Cambrian, coincident with the appearance of animal body fossils. It has been hypothesized that...