ORFcurator: molecular curation of genes and gene clusters in prokaryotic organisms (2004)
Rosenfeld, Jeffrey A., Sarkar, Indra N., Planet, Paul J., Figurski, David H., DeSalle, Rob
Summary: The ability to detect clusters of functionally related genes in multiple microbial genomes has enormous potential for enhancing studies on gene function and microbial evolution. The...
ORFcurator: molecular curation of genes and gene clusters in prokaryotic organisms (2004)
Rosenfeld, Jeffrey A., Sarkar, Indra N., Planet, Paul J., Figurski, David H., DeSalle, Rob
The ability to detect clusters of functionally related genes in multiple microbial genomes has enormous potential for enhancing studies on gene function and microbial evolution. The staggering amount...
ORFcurator: molecular curation of genes and gene clusters in prokaryotic organisms (2004)
Rosenfeld, Jeffrey A., Sarkar, Indra N., Planet, Paul J., Figurski, David H., DeSalle, Rob
The ability to detect clusters of functionally related genes in multiple microbial genomes has enormous potential for enhancing studies on gene function and microbial evolution. The staggering amount...
Scott C. Kachlany, Paul J. Planet, Mrinal K. Bhattacharjee, Evyenia Kollia, Rob Desalle, Daniel H. Fine, ...
The gram-negative coccobacillus, Actinobacillus actinomycetemcomitans, is the putative agent for localized juvenile periodontitis, a particularly destructive form of periodontal disease in...
Bechhofer, David H., Figurski, David H.
From our earlier work, we know that the korA gene of broad host range plasmid RK2 is located within the 50.4'-56.4' region. By additional sub-cloning of this region, we have mapped korA to the...
Planet, Paul J., Kachlany, Scott C., DeSalle, Rob, Figurski, David H.
Macromolecular transport systems in bacteria currently are classified by function and sequence comparisons into five basic types. In this classification system, type II and type IV secretion systems...
Rosche, Thomas M., Siddique, Azeem, Larsen, Michelle H., Figurski, David H.
Replication of the broad-host-range, IncPα plasmid RK2 requires two plasmid loci: trfA, the replication initiator gene, and oriV, the origin of replication. While these determinants are sufficient...
Kachlany, Scott C., Planet, Paul J., Bhattacharjee, Mrinal K., Kollia, Evyenia, DeSalle, Rob, Fine, Daniel H., ...
The gram-negative coccobacillus, Actinobacillus actinomycetemcomitans, is the putative agent for localized juvenile periodontitis, a particularly destructive form of periodontal disease in...
Secretion of RTX Leukotoxin by Actinobacillus actinomycetemcomitans
Kachlany, Scott C., Fine, Daniel H., Figurski, David H.
Actinobacillus actinomycetemcomitans, the etiologic agent for localized juvenile periodontitis and certain other human infections, such as endocarditis, expresses a leukotoxin that acts on...
Bhattacharjee, Mrinal K., Kachlany, Scott C., Fine, Daniel H., Figurski, David H.
Cells of Actinobacillus actinomycetemcomitans, a gram-negative pathogen responsible for an aggressive form of juvenile periodontitis, form tenaciously adherent biofilms on solid surfaces. The...
Thomson, Valeri J., Bhattacharjee, Mrinal K., Fine, Daniel H., Derbyshire, Keith M., Figurski, David H.
Transposon mutagenesis in bacteria generally requires efficient delivery of a transposon suicide vector to allow the selection of relatively infrequent transposition events. We have developed an...
Siddique, Azeem, Figurski, David H.
Plasmids of incompatibility group P (IncP) are capable of replication and stable inheritance in a wide variety of gram-negative bacteria. Three determinants of IncP plasmids are components of an...
Schreiner, Helen C., Sinatra, Kathy, Kaplan, Jeffrey B., Furgang, David, Kachlany, Scott C., Planet, Paul J., ...
Actinobacillus actinomycetemcomitans is a Gram-negative coccobacillus that has been associated with localized aggressive periodontitis and infections of the heart, brain, and urinary tract. Wild-type...
Figurski, David H., Helinski, Donald R.
pRK212.2, a derivative of the broad host range plasmid RK2, contains two EcoRI cleavage fragments, A and B, neither of which can replicate by itself in Escherichia coli. Fragment A (41.7 kilobases),...
Planet, Paul J., Kachlany, Scott C., DeSalle, Rob, Figurski, David H.
Macromolecular transport systems in bacteria currently are classified by function and sequence comparisons into five basic types. In this classification system, type II and type IV secretion systems...
Rosche, Thomas M., Siddique, Azeem, Larsen, Michelle H., Figurski, David H.
Replication of the broad-host-range, IncPα plasmid RK2 requires two plasmid loci: trfA, the replication initiator gene, and oriV, the origin of replication. While these determinants are sufficient...
Kachlany, Scott C., Planet, Paul J., Bhattacharjee, Mrinal K., Kollia, Evyenia, DeSalle, Rob, Fine, Daniel H., ...
The gram-negative coccobacillus, Actinobacillus actinomycetemcomitans, is the putative agent for localized juvenile periodontitis, a particularly destructive form of periodontal disease in...
Secretion of RTX Leukotoxin by Actinobacillus actinomycetemcomitans
Kachlany, Scott C., Fine, Daniel H., Figurski, David H.
Actinobacillus actinomycetemcomitans, the etiologic agent for localized juvenile periodontitis and certain other human infections, such as endocarditis, expresses a leukotoxin that acts on...
Bhattacharjee, Mrinal K., Kachlany, Scott C., Fine, Daniel H., Figurski, David H.
Cells of Actinobacillus actinomycetemcomitans, a gram-negative pathogen responsible for an aggressive form of juvenile periodontitis, form tenaciously adherent biofilms on solid surfaces. The...
Thomson, Valeri J., Bhattacharjee, Mrinal K., Fine, Daniel H., Derbyshire, Keith M., Figurski, David H.
Transposon mutagenesis in bacteria generally requires efficient delivery of a transposon suicide vector to allow the selection of relatively infrequent transposition events. We have developed an...
Siddique, Azeem, Figurski, David H.
Plasmids of incompatibility group P (IncP) are capable of replication and stable inheritance in a wide variety of gram-negative bacteria. Three determinants of IncP plasmids are components of an...
Schreiner, Helen C., Sinatra, Kathy, Kaplan, Jeffrey B., Furgang, David, Kachlany, Scott C., Planet, Paul J., ...
Actinobacillus actinomycetemcomitans is a Gram-negative coccobacillus that has been associated with localized aggressive periodontitis and infections of the heart, brain, and urinary tract. Wild-type...
Figurski, David H., Helinski, Donald R.
pRK212.2, a derivative of the broad host range plasmid RK2, contains two EcoRI cleavage fragments, A and B, neither of which can replicate by itself in Escherichia coli. Fragment A (41.7 kilobases),...
Tomich, Mladen, Fine, Daniel H., Figurski, David H.
The tad locus of Actinobacillus actinomycetemcomitans encodes genes for the biogenesis of Flp pili, which allow the bacterium to adhere tenaciously to surfaces and form strong biofilms. Although tad...
Balashova, Nataliya V., Park, Diane H., Patel, Jigna K., Figurski, David H., Kachlany, Scott C.
Aggregatibacter (Actinobacillus) actinomycetemcomitans is a gram-negative oral pathogen that is the etiologic agent of localized aggressive periodontitis and systemic infections. A....
Clock, Sarah A., Planet, Paul J., Perez, Brenda A., Figurski, David H.
Prokaryotic secretion relies on proteins that are widely conserved, including NTPases and secretins, and on proteins that are system specific. The Tad secretion system in Aggregatibacter...
Kram, Karin E., Hovel-Miner, Galadriel A., Tomich, Mladen, Figurski, David H.
The tad (tight adherence) locus of Aggregatibacter actinomycetemcomitans includes genes for the biogenesis of Flp pili, which are necessary for bacterial adhesion to surfaces, biofilm formation, and...
Knowledge Aggregation from Organized Sets (KAOS) Applied to Clinical Data
Sarkar, Indra Neil, Planet, Paul J., DeSalle, Rob, Figurski, David H.
Bacterial Conjugation in the Cytoplasm of Mouse Cells▿
Lim, Yin Mei, Bhattacharjee, Mrinal K., Figurski, David H., Schon, Eric A.
Intracellular pathogenic organisms such as salmonellae and shigellae are able to evade the effects of many antibiotics because the drugs are not able to penetrate the plasma membrane. In addition,...