Westfall, Margaret V., Pasyk, Krystyna A., Yule, David I., Samuelson, Linda C., Metzger, Joseph M.
Differentiation cultures of embryonic stem (ES) cells can be a useful in vitro system for understanding cardiac myocyte development. However, cell morphometry, sarcomere development, and functional...
Yule, David I., Williams, John A.
The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with...
Yule, David I., Wagner, Andreas C. C., Williams, John A.
In individual fura-2 loaded cells of rat pancreatic acini endothelin-1 (ET-1) (10-50 nM) induced sustained oscillations in [Ca2+]i. At higher concentrations a larger, but transient increase in...
Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells (1991)
Yule, David I., Williams, John A.
Microfluorimetry of fura-2 was used to monitor [Ca2+]i in single cells stimulated with the G-protein activating agent mastoparan. Mastoparan induced the generation of [Ca2+]i oscillations, which in...
Mignen, Olivier, Thompson, Jill L, Yule, David I, Shuttleworth, Trevor J
ARC channels (arachidonate-regulated Ca2+-selective channels) are a novel type of highly Ca2+-selective channel that are specifically activated by low concentrations of agonist-induced arachidonic...
Mignen, Olivier, Thompson, Jill L, Yule, David I, Shuttleworth, Trevor J
ARC channels (arachidonate-regulated Ca2+-selective channels) are a novel type of highly Ca2+-selective channel that are specifically activated by low concentrations of agonist-induced arachidonic...
Straub, Stephen V., Giovannucci, David R., Yule, David I.
In pancreatic acinar cells, inositol 1,4,5-trisphosphate (InsP3)–dependent cytosolic calcium ([Ca2+]i) increases resulting from agonist stimulation are initiated in an apical “trigger zone,”...
Giovannucci, David R, Bruce, Jason I. E, Straub, Stephen V, Arreola, Jorge, Sneyd, James, Shuttleworth, Trevor J, ...
The dynamics of Ca2+ release and Ca2+-activated Cl− currents in two related, but functionally distinct exocrine cells, were studied to gain insight into how the molecular specialization of Ca2+...
LeBeau, Andrew P., Yule, David I., Groblewski, Guy E., Sneyd, James
The properties of inositol 1,4,5-trisphosphate (IP3)-dependent intracellular calcium oscillations in pancreatic acinar cells depend crucially on the agonist used to stimulate them. Acetylcholine or...
Betzenhauser, Matthew J., Wagner, Larry E., Iwai, Miwako, Michikawa, Takayuki, Mikoshiba, Katsuhiko, Yule, David I.
ATP enhances Ca2+ release from inositol (1,4,5)-trisphosphate receptors (InsP3R). However, the three isoforms of InsP3R are reported to respond to ATP with differing sensitivities. Ca2+ release...
Wagner II, Larry E, Joseph, Suresh K, Yule, David I
Phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP3R) by PKA represents an important, common route for regulation of Ca2+ release. Following phosphorylation of the S2 splice variant of...
Visualizing form and function in organotypic slices of the adult mouse parotid gland
Warner, Jennifer D., Peters, Christian G., Saunders, Rudel, Won, Jong Hak, Betzenhauser, Matthew J., Gunning, William T., ...
An organotypic slice preparation of the adult mouse parotid salivary gland amenable to a variety of optical assessments of fluid and protein secretion dynamics is described. The semi-intact...
Park, Hyung Seo, Betzenhauser, Matthew J., Won, Jong Hak, Chen, Ju, Yule, David I.
Calcium release through inositol (1,4,5)-trisphosphate receptors (InsP3R) is the primary signal driving digestive enzyme and fluid secretion from pancreatic acinar cells. The type 2 (InsP3R2) and...