Deborah D. Crane

The 16-kDa α-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages

Yuan, Ying, Crane, Deborah D., Simpson, R. Mark, Zhu, YaQi, Hickey, Mark J., Sherman, David R., ...

Although the 16-kDa α-crystallin homologue of Mycobacterium tuberculosis (MTB) is the dominant protein produced by stationary phase cultures in vitro, it is undetectable in logarithmically growing...

Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes

Belland, Robert J., Scidmore, Marci A., Crane, Deborah D., Hogan, Daniel M., Whitmire, William, McClarty, Grant, ...

Chlamydia trachomatis is an obligate intracellular human bacterial pathogen that infects epithelial cells of the eye and genital tract. Infection can result in trachoma, the leading cause of...

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

Belland, Robert J., Zhong, Guangming, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, Sharma, Jyotika, ...

Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological agent of debilitating sexually transmitted and ocular diseases in humans. The organism is an obligate...

Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation

Belland, Robert J., Nelson, David E., Virok, Dezso, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, ...

Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role...

Chlamydial Infection Induces Pathobiotype-Specific Protein Tyrosine Phosphorylation in Epithelial Cells

Virok, Dezso P., Nelson, David E., Whitmire, William M., Crane, Deborah D., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are strict obligate intracellular pathogens that exhibit marked differences in host range and tissue tropism despite sharing a remarkable level of genomic synteny....

Bactericidal Activity of First-Choice Antibiotics against Gamma Interferon-Induced Persistent Infection of Human Epithelial Cells by Chlamydia trachomatis

Reveneau, Nathalie, Crane, Deborah D., Fischer, Elizabeth, Caldwell, Harlan D.

Chlamydia trachomatis is responsible for clinically important chronic inflammatory diseases of humans, including trachoma and pelvic inflammatory disease. Persistent infection of mucosal sites may...

Chlamydial IFN-γ immune evasion is linked to host infection tropism

Nelson, David E., Virok, Dezso P., Wood, Heidi, Roshick, Christine, Johnson, Raymond M., Whitmire, William M., ...

Chlamydiae are obligate intracellular pathogens that can exhibit a broad host range in infection tropism despite maintaining near genomic identity. Here, we have investigated the molecular basis for...

Inhibition of Chlamydiae by Primary Alcohols Correlates with the Strain-Specific Complement of Plasticity Zone Phospholipase D Genes

Nelson, David E., Crane, Deborah D., Taylor, Lacey D., Dorward, David W., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are obligate intracellular pathogens that have a unique biphasic developmental cycle and interactions with host cells. Many genes that dictate host infection tropism...

Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen

Crane, Deborah D., Carlson, John H., Fischer, Elizabeth R., Bavoil, Patrik, Hsia, Ru-ching, Tan, Chun, ...

Infections caused by the obligate intracellular pathogen Chlamydia trachomatis have a marked impact on human health. C. trachomatis serovariants are the leading cause of bacterial sexually...

The 16-kDa α-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages

Yuan, Ying, Crane, Deborah D., Simpson, R. Mark, Zhu, YaQi, Hickey, Mark J., Sherman, David R., ...

Although the 16-kDa α-crystallin homologue of Mycobacterium tuberculosis (MTB) is the dominant protein produced by stationary phase cultures in vitro, it is undetectable in logarithmically growing...

Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes

Belland, Robert J., Scidmore, Marci A., Crane, Deborah D., Hogan, Daniel M., Whitmire, William, McClarty, Grant, ...

Chlamydia trachomatis is an obligate intracellular human bacterial pathogen that infects epithelial cells of the eye and genital tract. Infection can result in trachoma, the leading cause of...

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

Belland, Robert J., Zhong, Guangming, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, Sharma, Jyotika, ...

Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological agent of debilitating sexually transmitted and ocular diseases in humans. The organism is an obligate...

Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation

Belland, Robert J., Nelson, David E., Virok, Dezso, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, ...

Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role...

Chlamydial Infection Induces Pathobiotype-Specific Protein Tyrosine Phosphorylation in Epithelial Cells

Virok, Dezso P., Nelson, David E., Whitmire, William M., Crane, Deborah D., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are strict obligate intracellular pathogens that exhibit marked differences in host range and tissue tropism despite sharing a remarkable level of genomic synteny....

Bactericidal Activity of First-Choice Antibiotics against Gamma Interferon-Induced Persistent Infection of Human Epithelial Cells by Chlamydia trachomatis

Reveneau, Nathalie, Crane, Deborah D., Fischer, Elizabeth, Caldwell, Harlan D.

Chlamydia trachomatis is responsible for clinically important chronic inflammatory diseases of humans, including trachoma and pelvic inflammatory disease. Persistent infection of mucosal sites may...

Chlamydial IFN-γ immune evasion is linked to host infection tropism

Nelson, David E., Virok, Dezso P., Wood, Heidi, Roshick, Christine, Johnson, Raymond M., Whitmire, William M., ...

Chlamydiae are obligate intracellular pathogens that can exhibit a broad host range in infection tropism despite maintaining near genomic identity. Here, we have investigated the molecular basis for...

Inhibition of Chlamydiae by Primary Alcohols Correlates with the Strain-Specific Complement of Plasticity Zone Phospholipase D Genes

Nelson, David E., Crane, Deborah D., Taylor, Lacey D., Dorward, David W., Goheen, Morgan M., Caldwell, Harlan D.

Members of the genus Chlamydia are obligate intracellular pathogens that have a unique biphasic developmental cycle and interactions with host cells. Many genes that dictate host infection tropism...

Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen

Crane, Deborah D., Carlson, John H., Fischer, Elizabeth R., Bavoil, Patrik, Hsia, Ru-ching, Tan, Chun, ...

Infections caused by the obligate intracellular pathogen Chlamydia trachomatis have a marked impact on human health. C. trachomatis serovariants are the leading cause of bacterial sexually...

Chlamydia trachomatis Species-Specific Induction of Ezrin Tyrosine Phosphorylation Functions in Pathogen Entry▿

Swanson, Kena A., Crane, Deborah D., Caldwell, Harlan D.

Chlamydia trachomatis is an obligate intracellular pathogen of humans that exhibits species-specific biological characteristics in its early interactions with host cells that are likely important to...

The Chlamydia trachomatis Plasmid Is a Transcriptional Regulator of Chromosomal Genes and a Virulence Factor▿ †

Carlson, John H., Whitmire, William M., Crane, Deborah D., Wicke, Luke, Virtaneva, Kimmo, Sturdevant, Daniel E., ...

Chlamydia trachomatis possesses a cryptic 7.5-kb plasmid of unknown function. Here, we describe a comprehensive molecular and biological characterization of the naturally occurring plasmidless human...