Deborah L. Gumucio

Functional DNA in Humans and Chimpanzees Shows They Are More Similar to Each Other Than Either is to Other Apes (2009)

Robert Boyd, Roger S. Fouts, Morris Goodman, Lawrence I. Grossman, Deborah L. Gumucio, Mary Lee, ...

ISBN#: 0-87724-032-9 These essays are the result of an interdisciplinary study program organized by the American Academy of Arts and Sciences and supported by the National Science Foundation under...

Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways (2008)

Charlie W. Lees, William J. Zacharias, Mark Tremelling, Colin L. Noble, Elaine R. Nimmo, Albert Tenesa, ...

BackgroundUlcerative colitis (UC) and Crohn's disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with considerable morbidity. The hedgehog...

Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: A prominent splice isoform lacks the C-terminal domain that is highly mutated in familial mediterranean fever (2004)

Diaz, Arturo, Hu, Chunbo, Kastner, Daniel L., Schaner, Philip, Reginato, Anthony M., Richards, Neil, ...

Objective To investigate the expression of the familial Mediterranean fever (FMF) gene ( MEFV ) in human synovial fibroblasts. Methods MEFV messenger RNA in synovial fibroblasts, chondrocytes, and...

Villin: A marker for development of the epithelial pyloric border (2002)

Braunstein, Evan M., Qiao, Xiaotan T., Madison, Blair, Pinson, Kathleen I., Dunbar, Laura, Gumucio, Deborah L.

In the adult gastrointestinal tract, the morphologic borders between esophagus and stomach and between stomach and small intestine are literally one cell thick. The patterning mechanisms that...

Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli (1998)

Pinson, Kathleen I., Dunbar, Laura, Samuelson, Linda C., Gumucio, Deborah L.

The small intestine is functionally dependent on the presence of the brush border, a tightly packed array of microvilli that forms the amplified apical surface of absorptive cells. In the core of...

High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human {beta} globin cluster (1995)

Yant, Stephen R., Zhu, Wei, Millinoff, David, Slightom, Jerry L., Goodman, Morris, Gumucio, Deborah L.

PCR-assisted binding site selection was used to define the sequence characteristics of high affinity YY1 binding sites. Compilation of the sequences of 189 selected oligonucleotides containing high...

Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene (1988)

Samuelson, Linda C., Wiebauer, Karin, Gumucio, Deborah L., Meisler, Miriam H.

The human genes encoding salivary amylase (AMY1) and pancreatic amylase (AMY2) are nearly identical in structure and sequence. We have used ribonuclease protection studies to identify the functional...

Interstrain Variation in Amylase Gene Copy Number and mRNA Abundance in Three Mouse Tissues

Meisler, Miriam H., Antonucci, Tammy K., Treisman, Laurelee O., Gumucio, Deborah L., Samuelson, Linda C.

Amylase expression in strain YBR differs in several respects from the standard mouse phenotype. The synthesis of salivary amylase is elevated twofold in YBR mice and the synthesis of pancreatic...

Interstrain Variation in Amylase Gene Copy Number and mRNA Abundance in Three Mouse Tissues

Meisler, Miriam H., Antonucci, Tammy K., Treisman, Laurelee O., Gumucio, Deborah L., Samuelson, Linda C.

Amylase expression in strain YBR differs in several respects from the standard mouse phenotype. The synthesis of salivary amylase is elevated twofold in YBR mice and the synthesis of pancreatic...

Conditional deletion of β1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality

Jones, Robert G., Li, Xiufen, Gray, Phillip D., Kuang, Jinqiu, Clayton, Frederic, Samowitz, Wade S., ...

Conditional deletion of β1 integrins in the intestinal epithelium, unlike in epidermal and mammary epithelia, of mice does not result in decreased cell adhesion and proliferation, but instead causes...

Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways

Lees, Charlie W, Zacharias, William J, Tremelling, Mark, Noble, Colin L, Nimmo, Elaine R, Tenesa, Albert, ...

Charlie Lees and colleagues identify a reduced-function variant of the hedgehog signaling pathway protein GLI1 that associates with inflammatory bowel disease, and investigate its role in a mouse...

Pyrin Modulates the Intracellular Distribution of PSTPIP1

Waite, Andrea L., Schaner, Philip, Richards, Neil, Balci-Peynircioglu, Banu, Masters, Seth L., Brydges, Susannah D., ...

PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum,...

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment

Chae, Jae Jin, Wood, Geryl, Richard, Katharina, Jaffe, Howard, Colburn, Nona T., Masters, Seth L., ...

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV, which encodes a 781–amino acid protein denoted pyrin. We have previously shown that pyrin regulates...