Klempa, Boris, Gajdusek, D Carleton, Krüger, Detlev H, ...
Hantaviruses, members of the family Bunyaviridae, are the causative agents of hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. Hantaviruses are currently demarcated into...
Klempa,Boris, Schmidt,Heiko A., Ulrich,Rainer, Kaluz,Stefan, Labuda,Milan, Meisel,Helga, ...
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa...
Klempa, Boris, Schmidt, Heiko A., Ulrich, Rainer, Kaluz, Stefan, Labuda, Milan, Meisel, Helga, ...
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa...
Klempa, Boris, Ulrich, Rainer, Meisel, Helga, Krüger, Detlev H., Schmidt, Heiko A., Kaluz, Stefan, ...
Roberts, Richard J., Belfort, Marlene, Bestor, Timothy, Bhagwat, Ashok S., Bickle, Thomas A., Bitinaite, Jurate, ...
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different...
Möncke-Buchner,Elisabeth, Reich,Stefanie, Mücke,Merlind, Reuter,Monika, Messer,Walter, Wanker,Erich, ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first exon of...
Möncke-Buchner,Elisabeth, Reich,Stefanie, Mücke,Merlind, Reuter,Monika, Messer,Walter, Wanker,Erich, ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first exon of...
Möncke-Buchner, Elisabeth, Reich, Stefanie, Mücke, Merlind, Reuter, Monika, Messer, Walter, Wanker, Erich, ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first exon of...
Möncke-Buchner, Elisabeth, Reich, Stefanie, Mücke, Merlind, Reuter, Monika, Messer, Walter, Wanker, Erich, ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first exon of...
Möncke-Buchner, Elisabeth, Reich, Stefanie, Mücke, Merlind, Reuter, Monika, Messer, Walter, Wanker, Erich E., ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal‐dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first...
Pein, Claus-Dietmar, Reuter, Monika, Meisel, Andreas, Cech, Dieter, Krüger, Detlev H.
The restriction endonuclease EcoRII Is unable to cleave DNA molecules when recognition sites are very far apart. The enzyme, however can be activated In the presence of DNA molecules with a high...
Recombination in Tula Hantavirus Evolution: Analysis of Genetic Lineages from Slovakia
Sibold, Claus, Meisel, Helga, Krüger, Detlev H., Labuda, Milan, Lysy, Jan, Kozuch, Oto, ...
To examine the evolution of Tula hantavirus (TUL), carried by the European common vole (Microtus arvalis and M. rossiaemeridionalis), we have analyzed genetic variants from Slovakia, the country...
Prösch, Susanna, Schielke, Eva, Reip, Angela, Meisel, Helga, Volk, Hans-Dieter, Einhäupl, Karl M., ...
Human cytomegalovirus (HCMV) encephalitis in adult nonimmunosuppressed patients has rarely been reported. We have diagnosed HCMV encephalitis in an anti-HCMV immunoglobulin G-negative,...
EcoRII: a restriction enzyme evolving recombination functions?
Mücke, Merlind, Grelle, Gerlinde, Behlke, Joachim, Kraft, Regine, Krüger, Detlev H., Reuter, Monika
The restriction endonuclease EcoRII requires the cooperative interaction with two copies of the sequence 5′CCWGG for DNA cleavage. We found by limited proteolysis that EcoRII has a two-domain...
Counting CAG repeats in the Huntington’s disease gene by restriction endonuclease EcoP15I cleavage
Möncke-Buchner, Elisabeth, Reich, Stefanie, Mücke, Merlind, Reuter, Monika, Messer, Walter, Wanker, Erich E., ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first exon of...
Hantavirus Infection of Dendritic Cells
Raftery, Martin J., Kraus, Annette A., Ulrich, Rainer, Krüger, Detlev H., Schönrich, Günther
Dendritic cells (DCs) play a pivotal role as antigen-presenting cells in the antiviral immune response. Here we show that Hantaan virus (HTNV), which belongs to the Bunyaviridae family (genus...
Klempa, Boris, Schmidt, Heiko A., Ulrich, Rainer, Kaluz, Stefan, Labuda, Milan, Meisel, Helga, ...
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa...
Roberts, Richard J., Belfort, Marlene, Bestor, Timothy, Bhagwat, Ashok S., Bickle, Thomas A., Bitinaite, Jurate, ...
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different...
Klempa, Boris, Meisel, Helga, Räth, Silvana, Bartel, Jan, Ulrich, Rainer, Krüger, Detlev H.
Hantavirus species Tula (TULV) is carried by European common voles (Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became...
Krüger, Detlev H., Hansen, Sigrid, Chernin, Leonid S.
Phage T7 infects male (F-plasmid-carrying) Escherichia coli cells abortively, whereas the closely related phage T3 grows normally. The inability or ability of phage to replicate in male host cells...
Krüger, Detlev H., Hansen, Sigrid, Reuter, Monika
In host cells containing the Salmonella typhimurium DNA restriction-modification systems SA+ and SB+, replication of the ocr+ bacteriophages T3 and T7 is not impaired. However, ocr (gene 0.3) mutants...
Gene expression analysis of plant host–pathogen interactions by SuperSAGE
Matsumura, Hideo, Reich, Stefanie, Ito, Akiko, Saitoh, Hiromasa, Kamoun, Sophien, Winter, Peter, ...
The type III restriction endonuclease EcoP15I was used in isolating fragments of 26 bp from defined positions of cDNAs. We call this substantially improved variant to the conventional serial analysis...
First Molecular Identification of Human Dobrava Virus Infection in Central Europe
Klempa, Boris, Schütt, Morten, Auste, Brita, Labuda, Milan, Ulrich, Rainer, Meisel, Helga, ...
Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava...
Kraus, Annette A., Raftery, Martin J., Giese, Thomas, Ulrich, Rainer, Zawatzky, Rainer, Hippenstiel, Stefan, ...
Hantaviruses represent important human pathogens and can induce hemorrhagic fever with renal syndrome (HFRS), which is characterized by endothelial dysfunction. Both pathogenic and nonpathogenic...
Meier, Johannes, Lienicke, Uta, Tschirch, Edda, Krüger, Detlev H., Wauer, Roland R., Prösch, Susanna
In a clinical trial, the incidence of cytomegalovirus reactivation in breastfeeding mothers and transmission to their preterm infants were studied. Breast milk from 73 mothers as well as urine and...
Central European Dobrava Hantavirus Isolate from a Striped Field Mouse (Apodemus agrarius)
Klempa, Boris, Stanko, Michal, Labuda, Milan, Ulrich, Rainer, Meisel, Helga, Krüger, Detlev H.
Dobrava virus (DOBV) is a hantavirus that causes hemorrhagic fever with renal syndrome (HFRS) in Europe. It is hosted by at least two rodent species, Apodemus flavicollis and A. agrarius. According...
Recombination in Tula Hantavirus Evolution: Analysis of Genetic Lineages from Slovakia
Sibold, Claus, Meisel, Helga, Krüger, Detlev H., Labuda, Milan, Lysy, Jan, Kozuch, Oto, ...
To examine the evolution of Tula hantavirus (TUL), carried by the European common vole (Microtus arvalis and M. rossiaemeridionalis), we have analyzed genetic variants from Slovakia, the country...
Prösch, Susanna, Schielke, Eva, Reip, Angela, Meisel, Helga, Volk, Hans-Dieter, Einhäupl, Karl M., ...
Human cytomegalovirus (HCMV) encephalitis in adult nonimmunosuppressed patients has rarely been reported. We have diagnosed HCMV encephalitis in an anti-HCMV immunoglobulin G-negative,...
EcoRII: a restriction enzyme evolving recombination functions?
Mücke, Merlind, Grelle, Gerlinde, Behlke, Joachim, Kraft, Regine, Krüger, Detlev H., Reuter, Monika
The restriction endonuclease EcoRII requires the cooperative interaction with two copies of the sequence 5′CCWGG for DNA cleavage. We found by limited proteolysis that EcoRII has a two-domain...
Counting CAG repeats in the Huntington’s disease gene by restriction endonuclease EcoP15I cleavage
Möncke-Buchner, Elisabeth, Reich, Stefanie, Mücke, Merlind, Reuter, Monika, Messer, Walter, Wanker, Erich E., ...
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant inheritance. The disease is caused by a CAG trinucleotide repeat expansion located in the first exon of...
Hantavirus Infection of Dendritic Cells
Raftery, Martin J., Kraus, Annette A., Ulrich, Rainer, Krüger, Detlev H., Schönrich, Günther
Dendritic cells (DCs) play a pivotal role as antigen-presenting cells in the antiviral immune response. Here we show that Hantaan virus (HTNV), which belongs to the Bunyaviridae family (genus...
Klempa, Boris, Schmidt, Heiko A., Ulrich, Rainer, Kaluz, Stefan, Labuda, Milan, Meisel, Helga, ...
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa...
Roberts, Richard J., Belfort, Marlene, Bestor, Timothy, Bhagwat, Ashok S., Bickle, Thomas A., Bitinaite, Jurate, ...
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different...
Klempa, Boris, Meisel, Helga, Räth, Silvana, Bartel, Jan, Ulrich, Rainer, Krüger, Detlev H.
Hantavirus species Tula (TULV) is carried by European common voles (Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became...
Krüger, Detlev H., Hansen, Sigrid, Chernin, Leonid S.
Phage T7 infects male (F-plasmid-carrying) Escherichia coli cells abortively, whereas the closely related phage T3 grows normally. The inability or ability of phage to replicate in male host cells...
Krüger, Detlev H., Hansen, Sigrid, Reuter, Monika
In host cells containing the Salmonella typhimurium DNA restriction-modification systems SA+ and SB+, replication of the ocr+ bacteriophages T3 and T7 is not impaired. However, ocr (gene 0.3) mutants...
Gene expression analysis of plant host–pathogen interactions by SuperSAGE
Matsumura, Hideo, Reich, Stefanie, Ito, Akiko, Saitoh, Hiromasa, Kamoun, Sophien, Winter, Peter, ...
The type III restriction endonuclease EcoP15I was used in isolating fragments of 26 bp from defined positions of cDNAs. We call this substantially improved variant to the conventional serial analysis...
First Molecular Identification of Human Dobrava Virus Infection in Central Europe
Klempa, Boris, Schütt, Morten, Auste, Brita, Labuda, Milan, Ulrich, Rainer, Meisel, Helga, ...
Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava...
Kraus, Annette A., Raftery, Martin J., Giese, Thomas, Ulrich, Rainer, Zawatzky, Rainer, Hippenstiel, Stefan, ...
Hantaviruses represent important human pathogens and can induce hemorrhagic fever with renal syndrome (HFRS), which is characterized by endothelial dysfunction. Both pathogenic and nonpathogenic...
Meier, Johannes, Lienicke, Uta, Tschirch, Edda, Krüger, Detlev H., Wauer, Roland R., Prösch, Susanna
In a clinical trial, the incidence of cytomegalovirus reactivation in breastfeeding mothers and transmission to their preterm infants were studied. Breast milk from 73 mothers as well as urine and...
Central European Dobrava Hantavirus Isolate from a Striped Field Mouse (Apodemus agrarius)
Klempa, Boris, Stanko, Michal, Labuda, Milan, Ulrich, Rainer, Meisel, Helga, Krüger, Detlev H.
Dobrava virus (DOBV) is a hantavirus that causes hemorrhagic fever with renal syndrome (HFRS) in Europe. It is hosted by at least two rodent species, Apodemus flavicollis and A. agrarius. According...
Meisel, Helga, Wolbert, Anne, Razanskiene, Ausra, Marg, Andreas, Kazaks, Andris, Sasnauskas, Kestutis, ...
Human infections with Asian and European hantaviruses can result in hemorrhagic fever with renal syndromes of differing severities characterized by renal dysfunction and sometimes by pulmonary...
Schilling, Stefan, Emmerich, Petra, Klempa, Boris, Auste, Brita, Schnaith, Ebbo, Schmitz, Herbert, ...
In Europe, hemorrhagic fever with renal syndrome results mainly from infection with Puumala virus (PUUV) or Dobrava virus. For 31 patients from a hantavirus disease outbreak in Lower Bavaria, a...
Oltmann, Anke, Kämper, Stephanie, Staeck, Oliver, Schmidt-Chanasit, Jonas, Günther, Stephan, Berg, Thomas, ...
Hepatitis A virus (HAV) infection is rarely fatal except in patients with chronic liver disease. In the case reported here, an elderly women died of HAV infection 12 years after incomplete HAV...