Hipsley, Christy A, Himmelmann, Lin, Metzler, Dirk, Müller, Johannes
Abstract Background Although current molecular clock methods offer greater flexibility in modelling evolutionary events, calibration of the clock with dates from the fossil record is still...
Rody, Achim, Holtrich, Uwe, Pusztai, Laos, Liedtke, Cornelia, Gaetje, Regine, Ruckhaeberle, Eugen, ...
Abstract Introduction Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2)...
Multidimensional patterns of neuronal activity: how do we see them? (2008)
Jurjut, Ovidiu F, Nikolić, Danko, Singer, Wolf, Metzler, Dirk, Mureşan, Raul C
No abstract available.
Simultaneous Statistical Multiple Alignment and Phylogeny Reconstruction (2005)
Fleissner, Roland, Metzler, Dirk, Von Haeseler, Arndt
Although the reconstruction of phylogenetic trees and the computation of multiple sequence alignments are highly interdependent, these two areas of research lead quite separate lives, the former...
Statistical alignment based on fragment insertion and deletion models (2003)
Motivation: The topic of this paper is the estimation of alignments and mutation rates based on stochastic sequence–evolution models that allow insertions and deletions of subsequences...
Functional genomics in the chimpanzee (2002)
Enard, Wolfgang, Ebersberger, Ingo, Fischer, Anne, Heissig, Florian, Hellmann, Ines, Höffner, Barbara, ...
Poisson-Approximationen für genetische Fingerabdrücke / (1999)
Frankfurt (Main), Universiẗat, Diss., 1999.
Mikroreprod. eines Ms. 84 Bl. : graph. Darst.
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees
Ebersberger, Ingo, Metzler, Dirk, Schwarz, Carsten, Pääbo, Svante
A total of 8,859 DNA sequences encompassing ∼1.9 million base pairs of the chimpanzee genome were sequenced and compared to corresponding human DNA sequences. Although the average sequence...
Löwer, Martin, Weydig, Christiane, Metzler, Dirk, Reuter, Andreas, Starzinski-Powitz, Anna, Wessler, Silja, ...
Exported proteases of Helicobacter pylori (H. pylori) are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening of...
A Poisson model for gapped local alignments
Metzler, Dirk, Grossmann, Steffen, Wakolbinger, Anton
High score alignments of DNA sequences give evidence of a common ancestry or function. It is therefore natural to ask whether an observed high score could have arisen by pure chance, and to explore...
Brune, Verena, Tiacci, Enrico, Pfeil, Ines, Döring, Claudia, Eckerle, Susan, ...
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of...