Douglas J. Taatjes

Deleterious effects of lack of cardiac PAI-1 after coronary occlusion in mice and their pathophysiologic determinants (2007)

Fujii, Satoshi, Schneider, David J, Taatjes, Douglas J, Sobel, Burton E

We sought to delineate mechanisms through which the lack of plasminogen activator inhibitor (PAI)-1 in the heart affects remodeling of the heart early after myocardial infarction (MI). MI was induced...

Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. (2003)

Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Chen, Pojen P., McCrae, Keith R., Bovill, Edwin G., ...

The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have antibodies against...

Paradoxical inhibition of fibrinogen binding and potentiation of {alpha}-granule release by specific types of inhibitors of glycoprotein IIb-IIIa (2000)

Schneider, David J, Taatjes, Douglas J, Sobel, Burton E

Objective: To determine whether glycoprotein (GP) IIb–IIIa inhibitors can paradoxically augment activation of platelets, activation of GP IIb–IIIa, α-granule degranulation, and lysosome release...

Immunocytochemical localization of {beta}1,4 galactosyltransferase in epithelial cells from bovine tissues using monoclonal antibodies (1992)

Taatjes, Douglas J., Roth, Jürgen, Shaper, Nancy L., Shaper, Joel H.

Post-embedding immunocytochemistry was employed to investigate the distribution of UDP-galactose:N-acetylglucosamine galactosyltransferase (β1,4-GT) in epithelial cells from various bovine organs....

Studies on the subcellular site(s) of sialylation in rat hepatocytes and enterocytes : immunocytochemical localization of sialyltransferase and cytochemical detection of sialic acid residues with a lectin from the slug limax flavus / (1987)

Taatjes, Douglas J.

Microfiche in UB Basel vorhanden

Light deprivation and presumed photoreceptor cells in Hydra littoralis /--by Douglas J. Taatjes. (1982)

Taatjes, Douglas J.

Typescript (photocopy).

Laser Scanning Cytometer-based Assays for Measuring Host Cell Attachment and Invasion by the Human Pathogen, Toxoplasma gondii

Mital, Jeffrey, Schwarz, Janet, Taatjes, Douglas J., Ward, Gary E.

Gene Expression Profiles Reveal Increased mClca3 (Gob5) Expression and Mucin Production in a Murine Model of Asbestos-Induced Fibrogenesis

Sabo-Attwood, Tara, Ramos-Nino, Maria, Bond, Jeffrey, Butnor, Kelly J., Heintz, Nicholas, Gruber, Achim D., ...

To elucidate genes important in development or repair of asbestos-induced lung diseases, gene expression was examined in mice after inhalation of chrysotile asbestos for 3, 9, and 40 days. We...

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Robledo, Raymond F., Buder-Hoffmann, Sylke A., Cummins, Andrew B., Walsh, Eric S., Taatjes, Douglas J., Mossman, Brooke T.

Activation of extracellular signal-regulated kinases (ERK) has been associated with the advent of asbestos-associated apoptosis and proliferation in mesothelial and alveolar epithelial cells and may...

Persistent Localization of Activated Extracellular Signal-Regulated Kinases (ERK1/2) Is Epithelial Cell-Specific in an Inhalation Model of Asbestosis

Cummins, Andrew B., Palmer, Cathy, Mossman, Brooke T., Taatjes, Douglas J.

Asbestos fibers up-regulate the extracellular signal-regulated kinase (ERK1/2) pathway in mesothelial and pulmonary epithelial cells in vitro, but the cell-type expression patterns and intracellular...

Human Monoclonal Antiphospholipid Antibodies Disrupt the Annexin A5 Anticoagulant Crystal Shield on Phospholipid Bilayers: Evidence from Atomic Force Microscopy and Functional Assay

Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Chen, Pojen P., McCrae, Keith R., Bovill, Edwin G., ...

The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have antibodies against...

Asbestos-Induced Peribronchiolar Cell Proliferation and Cytokine Production Are Attenuated in Lungs of Protein Kinase C-δ Knockout Mice

Shukla, Arti, Lounsbury, Karen M., Barrett, Trisha F., Gell, Joanna, Rincon, Mercedes, Butnor, Kelly J., ...

The signaling pathways leading to the development of asbestos-associated diseases are poorly understood. Here we used normal and protein kinase C (PKC)-δ knockout (PKCδ−/−) mice to demonstrate...

Morphological and cytochemical determination of cell death by apoptosis

Taatjes, Douglas J., Sobel, Burton E., Budd, Ralph C.

Several modes of cell death are now recognized, including necrosis, apoptosis, and autophagy. Oftentimes the distinctions between these various modes may not be apparent, although the precise mode...

Unique Uptake of Acid-Prepared Mesoporous Spheres by Lung Epithelial and Mesothelioma Cells

Blumen, Steven R., Cheng, Kai, Ramos-Nino, Maria E., Taatjes, Douglas J., Weiss, Daniel J., Landry, Christopher C., ...

Lung cancers, malignant mesotheliomas (MM), and fibrosis are devastating diseases with limited treatment strategies, in part due to poorly-effective drug delivery to affected areas of lung. We...

Imaging aspects of cardiovascular disease at the cell and molecular level

Taatjes, Douglas J., Wadsworth, Marilyn P., Quinn, Anthony S., Rand, Jacob H., Bovill, Edwin G., Sobel, Burton E.

Cell and molecular imaging has a long and distinguished history. Erythrocytes were visualized microscopically by van Leeuwenhoek in 1674, and microscope technology has evolved mightily since the...

Inhaled Asbestos Exacerbates Atherosclerosis in Apolipoprotein E–Deficient Mice via CD4+ T Cells

Fukagawa, Naomi K., Li, Muyao, Sabo-Attwood, Tara, Timblin, Cynthia R., Butnor, Kelly J., Gagne, Jessica, ...

Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos

Manning, Christopher B., Sabo-Attwood, Tara, Robledo, Raymond F., MacPherson, Maximilian B., Rincón, Mercedes, Vacek, Pamela, ...

The extracellular signal–regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear....

Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers

Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Chen, Pojen P., Hathcock, James J., Taatjes, Douglas J.

Treatment with the antimalarial drug hydroxychloroquine (HCQ) has been associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) and, in an animal model of APS, with...