Basu, S., Senior, R., Raftery, E. B., Lahiri, A.
The majority of post-myocardial infarction studies with β-blocking drugs involved earlier generations. Newer drugs of this family with additional vasodilating and free-radical suppression...
Senior, R., Basu, S., Handler, C., Raftery, E. B., Lahiri, A.
To compare the diagnostic accuracy between dobutamme echocardiography and treadmill exercise electrocardiography in detecting coronary artery disease in hypertensive patients, 43 patients without...
The preventative effects of vasodilating beta-blockers in cardiovascular disease (1996)
The beta-blocking drugs are known to modify the course of hypertensive and atherosclerotic, heart disease and significantly reduce the mortality and morbidity associated with these diseases. The...
Vasodilating beta-blockers in heart failure (1995)
Carvedilol is a non-selective beta-adrenoceptor antagonist with vasodilating properties which has been shown to be effective in the management both of hypertension and of stable angina pectoris. In...
SENIOR, R., SRIDHARA, B. S., BASU, S., HENLEY, M., HANDLER, C. E., RAFTERY, E. B., ...
To compare the measurement of left ventricular ejection fraction obtained by two-dimensional echocardiography and by radionuclide ventriculography in patients following acute myocardial infarction,...
Raftery, E. B., Lahiri, A., Hughes, L. O., Rose, E. L.
This randomized, double-blind, parallel study compared the anti-anginal effects of nicorandil and atenolol in 37 patients with exercise-induced angina pectoris. At the end of a single-blind placebo...
A 72-year-old male was admitted to hospital with exertional dyspnoea of recent onset. Echocardiography showed a left ventricle which was severely hypokinetic on the anteroseptal and anterior wall...
Right atrial thrombus migration during echocardiography: a case for urgent intervention (1992)
SENIOR, R., COWELL, R., THOMAS, P., RAFTERY, E. B.
A 65-year-old woman presented with increasing shortness of breath, chest pain and ST-T wave abnormalities on the electrocardiogram suggestive of unstable angina. Cross-sectional echocardiography...
Improvement in left ventricular function after rapid weight loss in obesity (1992)
DASGUPTA, P., RAMHANMDANY, E., BRIGDEN, G., LAHIRI, A., MCLEAN, I., RAFTERY, E. B.
The effect of rapid weight reduction on left ventricular function and blood pressure was studied in 34 obese subjects, who all weighed more than 30% above their ideal body weight. Subjects...
Blood pressure changes during the game of squash (1992)
BRIGDEN, G. S., HUGHES, L. O., BROADHURST, P., RAFTERY, E. B.
The extent and pattern of the blood pressure response to the playing of squash was studied in five healthy volunteers using intra-arterial blood pressure recordings. Systolic pressure increased more...
Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug (1991)
BROADHURST, P., BRIGDEN, G., HITTEL, N., LAHIRI, A., RAFTERY, E. B.
The duration and magnitude of the hypotensive effect of a new, once daily dihydropyridine calcium channel blocking drug, OPC-13340, was assessed in 14 patients with essential hypertension during...
Haemodynamic advantage of the Valsalva manoeuvre during heavy resistance training (1989)
HUGHES, L. O., HEBER, M. E., LAHIRI, A., HARRIES, M., RAFTERY, E. B.
A nuclear probe was used to assess beat-to-beat changes in relative cardiac output in eight elite athletes during isometric exercise. Three subjects underwent simultaneous intra-arterial blood...
Rodrigues, E. A., Lahiri, A., Raftery, E. B.
A placebo-controlled double-blind randomized crossover study was carried out to assess the effects of chronic therapy with two calcium antagonists on left ventricular diastolic function in patients...
LAHIRI, A., ZANELLI, G. D., O'HARA, M. J., BOWLES, M. J., JONES, R. I., CAVE, A. P. D., ...
The state of left ventricular function and myocardial perfusion are important determinants of prognosis in patients with coronary artery disease and information on both can be valuable for planning...
KOHLI, R. S., KHURMI, N. S., KARDASH, M. M., HUGHES, L. O., LAHIRI, A., RAFTERY, E. B.
Bisoprolol is a new cardioselective beta-blocker with a long half-life. The efficacy of once daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 20 patients with stable angina using a...
The effects of beta-blocker therapy on diurnal variation of blood pressure (1983)
Plotting hourly mean blood pressures recorded continuously by an intra-arterial technique in fully ambulant subjects on a time scale has clearly outlined a circadian biorhythm which is a useful tool...
An effective conscious animal model of atrial fibrillation (1979)
WHITTINGTON, J. R., CROSS, M. R., RAFTERY, E. B.
In 11 fully conscious dogs with chronically implanted epicardial electrodes, 50 Hz sine-wave electrical stimulation of the left atrium reliably and repeatedly produced an arrhythmia which was...
The Indirect Method of Recording Blood Pressure (1968)
Authors' SynopsisIn a group of 50 healthy young females, pressure was determined from the right brachial artery using a direct recording technique and a standard indirect sphygmomanometer....
Goodwin, C. Stewart, Raftery, E. B., Goldberg, A. D., Skeggs, H., Till, A. E., Martin, C. M.
Using a randomized crossover design, 1-g intravenous doses of cephalothin and cefoxitin, a cephalosporinase-resistant cephamycin, were infused into 12 normal adult males over periods of 120, 30, and...
A correlative isotopic and histological study of soleal vein thrombosis
Wray, Richard, Rimmer, D., Denham, M., Raftery, E. B.
Thirteen patients are described in whom the results of 125I fibrinogen uptake testing in life were compared with the postmortem findings in the soleus muscle and in addition with direct radioactive...
Gould, B A, Kieso, H A, Hornung, R, Altman, D G, Cashman, P M, Raftery, E B
Self-recording of the blood pressure by patients away from hospital or office ("home blood pressure") has been advocated as providing a better estimate of "true" blood pressure. The reliability of...
Kieso, H A, Gould, B A, Mann, S, Hornung, R S, Altman, D G, Raftery, E B
Thirty patients with essential hypertension participated in a double blind crossover trial in which they were randomly allocated to treatment with either once daily slow release metoprolol (200 mg)...
Systemic Lupus Erythematosus Syndrome Induced by Practolol
Three patients with angina pectoris treated with practolol in varying doses developed a syndrome of arthralgia, particularly of the small joints of the hands, rash, fever, a raised E.S.R., and...
Effect of once-daily atenolol on ambulatory blood pressure.
Craig, M W, Kenny, D, Mann, S, Balasubramanian, V, Raftery, E B
Sudden death during ambulatory monitoring.
Lahiri, A, Balasubramanian, V, Raftery, E B
Three patients with ischaemic heart disease died suddenly while being monitored with an ambulatory tape recorder. Two had terminal ventricular fibrillation initiated by paired bidirectional...
Blood pressure and heart rate and withdrawal of antihypertensive drugs.
Goldberg, A D, Raftery, E B, Wilkinson, P
The immediate effects on heart rate and blood pressure of withdrawing antihypertensive drugs were studied over three-day periods in 26 patients. Four groups of drugs were studied. After withdrawal...
Primary Neuropathic Amyloidosis in Three Brothers
Zalin, A., Darby, A., Vaughan, S., Raftery, E. B.
Neuropathic primary amyloidosis has not been previously described in an English family. We present the clinical and pathological findings in three brothers with this condition and suggest that they...
Immunoscintigraphy for detecting acute myocardial infarction without electrocardiographic changes.
Jain, D, Lahiri, A, Raftery, E B
OBJECTIVE--To establish whether immunoscintigraphy with antibody to myosin may detect acute myocardial infarction without electrocardiographic changes. DESIGN--Prospective study of patients with...
Ambulatory electrocardiographic records in patients with transient cerebral attacks or palpitation.
Goldberg, A D, Raftery, E B, Cashman, P M
Continuous electrocardiographic (ECG) records were made over 24 hours in 130 ambulant outpatients complaining of syncope, dizzy turns, or palpitation. In all these patients resting ECGs had failed to...
Streptokinase in acute myocardial infarction: a controlled multicentre study in the United Kingdom.
Aber, C P, Bass, N M, Berry, C L, Carson, P H, Dobbs, R J, Fox, K M, ...
In a multicentre trial of streptokinase in acute myocardial infarction 302 patients received an intravenous infusion of 2 500 000 IU of streptokinase over 24 hours, while 293 patients served as...
Goodwin, C. Stewart, Raftery, E. B., Goldberg, A. D., Skeggs, H., Till, A. E., Martin, C. M.
Using a randomized crossover design, 1-g intravenous doses of cephalothin and cefoxitin, a cephalosporinase-resistant cephamycin, were infused into 12 normal adult males over periods of 120, 30, and...
A correlative isotopic and histological study of soleal vein thrombosis
Wray, Richard, Rimmer, D., Denham, M., Raftery, E. B.
Thirteen patients are described in whom the results of 125I fibrinogen uptake testing in life were compared with the postmortem findings in the soleus muscle and in addition with direct radioactive...
Gould, B A, Kieso, H A, Hornung, R, Altman, D G, Cashman, P M, Raftery, E B
Self-recording of the blood pressure by patients away from hospital or office ("home blood pressure") has been advocated as providing a better estimate of "true" blood pressure. The reliability of...
Kieso, H A, Gould, B A, Mann, S, Hornung, R S, Altman, D G, Raftery, E B
Thirty patients with essential hypertension participated in a double blind crossover trial in which they were randomly allocated to treatment with either once daily slow release metoprolol (200 mg)...
Systemic Lupus Erythematosus Syndrome Induced by Practolol
Three patients with angina pectoris treated with practolol in varying doses developed a syndrome of arthralgia, particularly of the small joints of the hands, rash, fever, a raised E.S.R., and...
Effect of once-daily atenolol on ambulatory blood pressure.
Craig, M W, Kenny, D, Mann, S, Balasubramanian, V, Raftery, E B
Sudden death during ambulatory monitoring.
Lahiri, A, Balasubramanian, V, Raftery, E B
Three patients with ischaemic heart disease died suddenly while being monitored with an ambulatory tape recorder. Two had terminal ventricular fibrillation initiated by paired bidirectional...
Blood pressure and heart rate and withdrawal of antihypertensive drugs.
Goldberg, A D, Raftery, E B, Wilkinson, P
The immediate effects on heart rate and blood pressure of withdrawing antihypertensive drugs were studied over three-day periods in 26 patients. Four groups of drugs were studied. After withdrawal...
Primary Neuropathic Amyloidosis in Three Brothers
Zalin, A., Darby, A., Vaughan, S., Raftery, E. B.
Neuropathic primary amyloidosis has not been previously described in an English family. We present the clinical and pathological findings in three brothers with this condition and suggest that they...
Immunoscintigraphy for detecting acute myocardial infarction without electrocardiographic changes.
Jain, D, Lahiri, A, Raftery, E B
OBJECTIVE--To establish whether immunoscintigraphy with antibody to myosin may detect acute myocardial infarction without electrocardiographic changes. DESIGN--Prospective study of patients with...
Ambulatory electrocardiographic records in patients with transient cerebral attacks or palpitation.
Goldberg, A D, Raftery, E B, Cashman, P M
Continuous electrocardiographic (ECG) records were made over 24 hours in 130 ambulant outpatients complaining of syncope, dizzy turns, or palpitation. In all these patients resting ECGs had failed to...
Streptokinase in acute myocardial infarction: a controlled multicentre study in the United Kingdom.
Aber, C P, Bass, N M, Berry, C L, Carson, P H, Dobbs, R J, Fox, K M, ...
In a multicentre trial of streptokinase in acute myocardial infarction 302 patients received an intravenous infusion of 2 500 000 IU of streptokinase over 24 hours, while 293 patients served as...
Abnormal lymphocyte function is secondary to drug-induced autoimmunity.
Pugh, S, Pelton, B, Raftery, E B, Denman, A M
Abnormal lymphocyte function has been frequently reported in patients with connective tissue diseases but its significance has been uncertain. Sequential studies of lymphocyte function were carried...
First myocardial infarctions in Asian and white men.
Hughes, L. O., Raval, U., Raftery, E. B.
OBJECTIVE--To compare the presentation and natural course of first myocardial infarctions in immigrant Asians and the indigenous white population in Britain and the subsequent risk states of the two...
Disturbances of insulin in British Asian and white men surviving myocardial infarction.
Hughes, L. O., Cruickshank, J. K., Wright, J., Raftery, E. B.
OBJECTIVE--To examine the role of insulin as a cardiovascular risk factor in British Asian and white men. DESIGN--Case-controlled study of survivors of first myocardial infarction. SETTING--District...
Ligation of the hepatic artery in the treatment of heart failure due to hepatic haemangiomatosis
Rake, M. O., Liberman, M. M., Dawson, J. L., Evans, Rachel, Raftery, E. B., Laws, J., ...
An infant presenting with high-output cardiac failure and a single large diffuse haemangioma of the liver is described. Corticosteroid therapy failed to produce any improvement, but hepatic artery...
Coital blood pressure in hypertensives. Cephalgia, syncope, and the effects of beta-blockade.
Mann, S, Craig, M W, Gould, B A, Melville, D I, Raftery, E B
During the continuous monitoring of intra-arterial blood pressure in ambulant hypertensive subjects, 18 episodes of coitus were recorded in 11 subjects. Peak values of up to 300/175 mmHg found, the...
Reversible ischaemia of right ventricle detected by exercise thallium-201 scintigraphy.
Lahiri, A, Carboni, G P, Crawley, J W, Raftery, E B
Exercise and redistribution thallium-201 imaging is commonly used for the detection and evaluation of left ventricular ischaemia and infarction. The right ventricle is frequently visualised after...
Davies, A B, Bala Subramanian, V, Cashman, P M, Raftery, E B
Simultaneous and accurate recording of arterial blood pressure and ST segment changes is fraught with technical difficulties. We have developed a new system to enable accurate reproduction of the...
Circadian rhythm of blood pressure in patients dependent on ventricular demand pacemakers.
Davies, A B, Gould, B A, Cashman, P M, Raftery, E B
The reported circadian rhythm of blood pressure variability with a rise in pressure before awakening has been the subject of controversy. Previous studies have suggested that since heart rate...
Lahiri, A, Bowles, M J, Jones, R I, Crawley, J C, Raftery, E B
The nuclear probe was used for measuring left ventricular function in 11 normal subjects and the results compared with those using a digital gammacamera. The probe was then used to measure left...
Indirect measurement of blood pressure during exercise testing can be misleading.
Gould, B A, Hornung, R S, Altman, D G, Cashman, P M, Raftery, E B
Indirect blood pressures recorded with a random zero sphygmomanometer were compared with simultaneous intra-arterial blood pressures recorded with the Oxford system. Twenty five patients undertook a...
Detection of high risk coronary artery disease by thallium imaging.
O'Hara, M J, Lahiri, A, Whittington, J R, Crawley, J C, Raftery, E B
One hundred and three patients who underwent coronary arteriography were studied by thallium imaging and the results analysed by Bayesian principles to assess the usefulness of semiquantitative...
Lahiri, A, Balasubramanian, V, Millar Craig, M W, Crawley, J, Raftery, E B
Two hundred and fifteen patients with previous myocardial infarction were investigated between four and six months after the acute episode by computer assisted 12 lead exercise electrocardiography....
Ambulatory ST segment monitoring. Problems, pitfalls, solutions, and clinical application.
Balasubramanian, V, Lahiri, A, Green, H L, Stott, F D, Raftery, E B
The introduction of frequency modulated recording systems for ambulatory electrocardiographic monitoring (Oxford Medilog mark 2 and Cardiodyne cassette recorders) prompted comparison with a...
Effects of chronic beta-blockade on intra-arterial blood pressure during motor car driving.
Millar-Craig, M W, Mann, S, Balasubramanian, V, Cashman, P, Raftery, E B
Continuous intra-arterial blood pressure recordings during motor car driving were performed in 15 patients with untreated essential hypertension, using the "Oxford" recording technique. Each subject...
Transcutaneous aortovelography. A quantitative evaluation.
Sequeira, R F, Light, L H, Cross, G, Raftery, E B
The haemotachograph is a non-invasive ultrasonic Doppler-shift instrument designed to measure the velocity of blood in the arch of the aorta by a technique referred to as transcutaneous...
Goldberg, A D, Raftery, E B, Cashman, P M, Stott, F D
Continuous recording of intra-arterial blood pressure and electrocardiograms has been performed in 41 ambulant untreated essential hypertensive subjects for periods up to 48 hours. Statistical...
Senior, R., Glenville, B., Basu, S., Sridhara, B. S., Anagnostou, E., Stanbridge, R., ...
OBJECTIVES--To evaluate the concordance between thallium-201 uptake and echocardiographic wall thickening, which are both indicators of potentially reversible myocardial dysfunction, in patients with...
Evaluation of contrast media used in man for coronary arteriography
Banks, D. C., Raftery, E. B., Oram, S.
The electrocardiographic changes induced by the injection of four contrast media into the right and left coronary arteries of man are described. Comparisons have been made between the different...
Ambulatory blood pressure and assessment of pacemaker function.
Jones, R I, Cashman, P M, Hornung, R S, Prince, H, Bassein, L, Raftery, E B
Ten patients in sinus rhythm with ventricular demand (VVI) pacemakers implanted for the sick sinus syndrome underwent 24 hour ambulatory blood pressure and electrocardiographic recording by a...
The ST segment of the ambulatory electrocardiogram in a normal population.
Kohli, R S, Cashman, P M, Lahiri, A, Raftery, E B
The behaviour of the ST segment in everyday life was studied by ambulatory electrocardiography in 111 normal volunteers. Fifteen were excluded because of abnormal exercise responses (10 subjects) and...
Subclinical cardiac dysfunction in acromegaly: evidence for a specific disease of heart muscle.
Rodrigues, E A, Caruana, M P, Lahiri, A, Nabarro, J D, Jacobs, H S, Raftery, E B
Acromegaly is associated with an increased cardiac morbidity and mortality, but it is not clear whether this is the result of increased incidence of hypertension and coronary heart disease or of a...
O'Hara, M J, Jones, R I, Lahiri, A, Raftery, E B
The high count sensitivity of the non-imaging nuclear probe affords the possibility of measuring left ventricular ejection fraction continuously during short term interventions. The nuclear probe was...
Caruana, M, Al-Khawaja, I, Lahiri, A, Lewis, J, Raftery, E B
Three measurements of diastolic filling were compared in 29 patients with essential hypertension and 27 age matched normotensive controls. Systolic function was normal in all but one of the patients....
24 h blood pressure control with the once daily calcium antagonist, amlodipine.
Heber, M E, Brigden, G, Al-Khawaja, I, Raftery, E B
1. Amlodipine is a novel calcium antagonist which, although pharmacologically similar to other dihydropyridine calcium antagonists, has a long plasma half-life, permitting steady state blood levels...
Caruana, M P, Heber, M, Brigden, G, Raftery, E B
1. The effects of fenoldopam, an orally active, specific dopamine-1 receptor agonist, were studied in eleven patients with essential hypertension, using intra-arterial blood pressure recording and...
The effects of long-acting pinacidil on intra-arterial blood pressure.
Caruana, M P, Al-Khawaja, I, Royston, P, Raftery, E B
We have tested the efficacy of a new long-acting preparation of pinacidil, an arterial vasodilator, using continuous intra-arterial ambulatory blood pressure recording. An acute dose produced a...
Jones, R. I., Hornung, R. S., Sonecha, T., Raftery, E. B.
1 The antihypertensive effect of a new slow channel blocking drug, nicardipine, has been assessed using the `Oxford' system for ambulatory monitoring and physiological testing in 14 patients with...
Bowles, M. J., Khurmi, N. S., O'Hara, M. J., Raftery, E. B.
1 The efficacy of a new dihydropyridine derivative, nicardipine, with slow calcium channel blocking activity was evaluated objectively in three groups of patients with chronic stable angina, by...
Nicardipine and verapamil in essential hypertension
Al-Khawaja, I. M., Caruana, M. P., Lahiri, A., Whittington, J. R., Lewis, J. G., Raftery, E. B.
1 Nicardipine 30 mg three times daily and verapamil 160 mg twice daily have been compared in 30 patients with essential hypertension using a two-period crossover clinical trial with 6 week treatment...
Rodrigues, E. A., Al-Khawaja, I. M., Lahiri, A., Raftery, E. B.
1 A double-blind, cross-over protocol was used to study the effects of chronic therapy with nicardipine and verapamil on left ventricular function in 21 patients with chronic stable angina. Rest and...
Propranolol LA and ambulatory blood pressure
Mann, Stewart, Millar Craig, M. W., Balasubramanian, V., Raftery, E. B.
A study of the antihypertensive action of xipamide using ambulatory intra-arterial monitoring.
Raftery, E B, Melville, D I, Gould, B A, Mann, S, Whittington, J R
1 The antihypertensive activity of the diuretic xipamide has been studied in 18 patients with mild/moderate essential hypertension using the technique of continuous ambulatory intra-arterial blood...
Once daily beta-adrenoceptor blockade in hypertension: an ambulatory assessment.
Mann, S, Craig, M W, Balasubramanian, V, Raftery, E B
1 The ambulant intra-arterial blood pressure of eighteen hypertensive subjects was monitored before and again after 3 months treatment with thrice daily sotalol (six patients), twice daily pindolol...
Rapid reduction of blood pressure with acute oral labetalol.
Davies, A B, Bala Subramanian, V, Gould, B, Raftery, E B
1 The effect of acute oral administration of labetalol on intra-arterial pressures in a group of ten hypertensive patients has been evaluated. 2 A single dose of 200 mg labetalol produced a...
Gould, B A, Hornung, R S, Kieso, H, Mann, S, Raftery, E B
1 We have assessed the efficacy of Viskaldix, a combination of pindolol 10 mg and clopamide 5 mg using continuous intra-arterial ambulatory blood pressure monitoring. 2 Fourteen of the sixteen...
Hornung, R S, Gould, B A, Kieso, H, Raftery, E B
1 The effect of once daily nadolol therapy in sixteen ambulant patients with essential hypertension has been closely assessed during exercise and over 24 h by continuous intra-arterial recording. 2...
Hornung, R S, Gould, B A, Kieso, H, Raftery, E B
1 The effectiveness of fixed combination tablets of timolol 10 mg, hydrochlorothiazide 25 mg and amiloride 2.5 mg (Moducren) once daily in the control of blood pressure has been assessed in fully...
Potassium supplements during long-term thiazide therapy for essential hypertension.
Wilkinson, P R, Tait, C, Hesp, R, Raftery, E B
Increasing doses of a slow-release potassium supplement were given to nine hypertensive patients previously treated for at least 18 months with bendrofluazide 10 mg daily. Serum potassium and total...
A comparative trial of clonidine, propranolol and placebo in the treatment of moderate hypertension.
1 A double-blind cross over trial between clonidine, propranolol and a placebo in patients with moderate hypertension has been performed. 2 Thirty-two patients completed the study which consisted of...
Once daily treatment of mild to moderate hypertension with xipamid: a controlled study.
Weber, J C, Bird, H, Cosh, J, Davies, P S, Dixon, A S, Lister, J, ...
A double-blind, placebo controlled, crossover trial of 20 and 40 mg of xipamid once daily in the treatment of mild to moderate hypertension is reported and some of the difficulties and pitfalls of...
Effect of labetalol in hypertension during exercise and postural changes.
Balasubramanian, V, Mann, S, Millar-Craig, M W, Raftery, E B
1 Fourteen hypertensive patients were studied by intra-arterial BP monitoring to quantify the effects of standardized physiological stresses: Valsalva manoeuvre, isometric, treadmill and bicycle...
Effect of labetalol on continuous ambulatory blood pressure.
Balasubramanian, V, Mann, S, Raftery, E B, Millar-Craig, M W, Altman, D
1 The hypotensive action of labetalol was evaluated during 24 h by continuous intra-arterial ambulatory monitoring in 14 patients. The dose used ranged from 300--1800 mg daily. 2 The drug caused a...
1 In a group of 23 patients with documented ischaemic heart disease who experienced angina pectoris, oral oxyfedrine (24 mg three times daily) was compared with isosorbide dinitrate (10 mg three...
An ambulatory trial of guanfacine
Mann, Stewart, Craig, Michael W. Millar, Melville, Donald I., Cashman, Peter M. M., Raftery, E. B.
1 The effects of acute and long-term treatment with guanfacine on ambulatory BP were studied.
Oxyfederine and propranolol--a controlled trial in angina pectoris.
1 A double-blind-crossover randomised trial was performed to compare the effects of oxyfedrine (maximum dose 32 mg three times daily), propranolol (maximum dose 120 mg three times daily) and placebo...
Propranolol LA and ambulatory blood pressure.
Mann, S, Craig, M W, Balasubramanian, V, Raftery, E B
1 The technique of continuous recording of intra-arterial blood pressure in ambulant hypertensives has been used to investigate the effects of a long-acting formulation of propranolol (propranolol...