Edgardo Moreno

Interaction of Brucella abortus Lipopolysaccharide with Major Histocompatibility Complex Class II Molecules in B Lymphocytes

Forestier, Claire, Moreno, Edgardo, Méresse, Stéphane, Phalipon, Armelle, Olive, Daniel, Sansonetti, Philippe, ...

Lipopolysaccharide (LPS), a major amphiphilic molecule located at the outer membrane of gram-negative bacteria, is a potent antigen known to induce specific humoral immune responses in infected...

The Outer Membrane of Brucella ovis Shows Increased Permeability to Hydrophobic Probes and Is More Susceptible to Cationic Peptides than Are the Outer Membranes of Mutant Rough Brucella abortus Strains

Freer, Enrique, Pizarro-Cerdá, Javier, Weintraub, Andrej, Bengoechea, José-Antonio, Moriyón, Ignacio, Hultenby, Kjell, ...

The permeability of the outer membrane (OM) to hydrophobic probes and its susceptibility to bactericidal cationic peptides were investigated for natural rough Brucella ovis and for mutant rough...

Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

Pizarro-Cerdá, Javier, Moreno, Edgardo, Sanguedolce, Veronique, Mege, Jean-Louis, Gorvel, Jean-Pierre

Virulent and attenuated Brucella abortus strains attach to and penetrate nonprofessional phagocytic HeLa cells. Compared to pathogenic Brucella, the attenuated strain 19 hardly replicates within...

Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes

Pizarro-Cerdá, Javier, Méresse, Stéphane, Parton, Robert G., Van Der Goot, Gisou, Sola-Landa, Alberto, Lopez-Goñi, Ignacio, ...

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308...

Characterization of Brucella abortus Soluble Antigen Employed in Immunoassay

Berman, David T., Wilson, Bambi L., Moreno, Edgardo, Angus, Robert D., Jones, Lois M.

A soluble antigen extract of Brucella abortus (BASA) has been prepared by the National Veterinary Services Laboratories and furnished to a number of workers who are examining antibody-mediated and...

Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2

Santamaría, Carlos, Larios, Silda, Quirós, Steve, Pizarro-Cerda, Javier, Gorvel, Jean-Pierre, Lomonte, Bruno, ...

The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake...

The Lipopolysaccharide of Brucella abortus BvrS/BvrR Mutants Contains Lipid A Modifications and Has Higher Affinity for Bactericidal Cationic Peptides

Manterola, Lorea, Moriyón, Ignacio, Moreno, Edgardo, Sola-Landa, Alberto, Weiss, David S., Koch, Michel H. J., ...

The two-component BvrS/BvrR system is essential for Brucella abortus virulence. It was shown previously that its dysfunction abrogates expression of some major outer membrane proteins and increases...

MyD88, but Not Toll-Like Receptors 4 and 2, Is Required for Efficient Clearance of Brucella abortus

Weiss, David S., Takeda, Kiyoshi, Akira, Shizuo, Zychlinsky, Arturo, Moreno, Edgardo

It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A....

Interaction of Brucella abortus Lipopolysaccharide with Major Histocompatibility Complex Class II Molecules in B Lymphocytes

Forestier, Claire, Moreno, Edgardo, Méresse, Stéphane, Phalipon, Armelle, Olive, Daniel, Sansonetti, Philippe, ...

Lipopolysaccharide (LPS), a major amphiphilic molecule located at the outer membrane of gram-negative bacteria, is a potent antigen known to induce specific humoral immune responses in infected...

The Outer Membrane of Brucella ovis Shows Increased Permeability to Hydrophobic Probes and Is More Susceptible to Cationic Peptides than Are the Outer Membranes of Mutant Rough Brucella abortus Strains

Freer, Enrique, Pizarro-Cerdá, Javier, Weintraub, Andrej, Bengoechea, José-Antonio, Moriyón, Ignacio, Hultenby, Kjell, ...

The permeability of the outer membrane (OM) to hydrophobic probes and its susceptibility to bactericidal cationic peptides were investigated for natural rough Brucella ovis and for mutant rough...

Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

Pizarro-Cerdá, Javier, Moreno, Edgardo, Sanguedolce, Veronique, Mege, Jean-Louis, Gorvel, Jean-Pierre

Virulent and attenuated Brucella abortus strains attach to and penetrate nonprofessional phagocytic HeLa cells. Compared to pathogenic Brucella, the attenuated strain 19 hardly replicates within...

Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes

Pizarro-Cerdá, Javier, Méresse, Stéphane, Parton, Robert G., Van Der Goot, Gisou, Sola-Landa, Alberto, Lopez-Goñi, Ignacio, ...

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308...

Characterization of Brucella abortus Soluble Antigen Employed in Immunoassay

Berman, David T., Wilson, Bambi L., Moreno, Edgardo, Angus, Robert D., Jones, Lois M.

A soluble antigen extract of Brucella abortus (BASA) has been prepared by the National Veterinary Services Laboratories and furnished to a number of workers who are examining antibody-mediated and...

Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2

Santamaría, Carlos, Larios, Silda, Quirós, Steve, Pizarro-Cerda, Javier, Gorvel, Jean-Pierre, Lomonte, Bruno, ...

The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake...

The Lipopolysaccharide of Brucella abortus BvrS/BvrR Mutants Contains Lipid A Modifications and Has Higher Affinity for Bactericidal Cationic Peptides

Manterola, Lorea, Moriyón, Ignacio, Moreno, Edgardo, Sola-Landa, Alberto, Weiss, David S., Koch, Michel H. J., ...

The two-component BvrS/BvrR system is essential for Brucella abortus virulence. It was shown previously that its dysfunction abrogates expression of some major outer membrane proteins and increases...

MyD88, but Not Toll-Like Receptors 4 and 2, Is Required for Efficient Clearance of Brucella abortus

Weiss, David S., Takeda, Kiyoshi, Akira, Shizuo, Zychlinsky, Arturo, Moreno, Edgardo

It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A....

BvrR/BvrS-Controlled Outer Membrane Proteins Omp3a and Omp3b Are Not Essential for Brucella abortus Virulence▿

Manterola, Lorea, Guzmán-Verri, Caterina, Chaves-Olarte, Esteban, Barquero-Calvo, Elías, De Miguel, María-Jesús, Moriyón, Ignacio, ...

The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent...

Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum

Celli, Jean, De Chastellier, Chantal, Franchini, Don-Marc, Pizarro-Cerda, Javier, Moreno, Edgardo, Gorvel, Jean-Pierre

The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and...

Neurobrucellosis in Stranded Dolphins, Costa Rica

Hernández-Mora, Gabriela, González-Barrientos, Rocío, Morales, Juan-Alberto, Chaves-Olarte, Esteban, Guzmán-Verri, Caterina, Baquero-Calvo, Elías, ...

Ten striped dolphins, Stenella coeruleoalba, stranded along the Costa Rican Pacific coast, had meningoencephalitis and antibodies against Brucella spp. Brucella ceti was isolated from cerebrospinal...

Serological Diagnosis of Brucella Infections in Odontocetes▿

Hernández-Mora, Gabriela, Manire, Charles A., González-Barrientos, Rocío, Barquero-Calvo, Elías, Guzmán-Verri, Caterina, Staggs, Lydia, ...

Brucella ceti causes disease in Odontoceti. The absence of control serum collections and the diversity of cetaceans have hampered the standardization of serological tests for the diagnosis of...