Linear combinations of docking affinities explain quantitative differences in RTK signaling
Gordus, Andrew, Krall, Jordan A, Beyer, Elsa M, Kaushansky, Alexis, Wolf-Yadlin, Alejandro, Sevecka, Mark, ...
Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing...