Enock Matovu

Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei

Matovu, Enock, Stewart, Mhairi L., Geiser, Federico, Brun, Reto, Mäser, Pascal, Wallace, Lynsey J. M., ...

Sleeping sickness, caused by Trypanosoma brucei spp., has become resurgent in sub-Saharan Africa. Moreover, there is an alarming increase in treatment failures with melarsoprol, the principal agent...

Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei

Matovu, Enock, Stewart, Mhairi L., Geiser, Federico, Brun, Reto, Mäser, Pascal, Wallace, Lynsey J. M., ...

Sleeping sickness, caused by Trypanosoma brucei spp., has become resurgent in sub-Saharan Africa. Moreover, there is an alarming increase in treatment failures with melarsoprol, the principal agent...

Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis

Thuita, John K., Kagira, John M., Mwangangi, David, Matovu, Enock, Turner, C. M. R., Masiga, Daniel

We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature...

A Combined CXCL10, CXCL8 and H-FABP Panel for the Staging of Human African Trypanosomiasis Patients

Hainard, Alexandre, Tiberti, Natalia, Robin, Xavier, Lejon, Veerle, Ngoyi, Dieudonné Mumba, Matovu, Enock, ...

The actual serological and parasitological tests used for the diagnosis of human African trypanosomiasis (HAT), also known as sleeping sickness, are not sensitive and specific enough. The card...

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal

Kazibwe, Anne J. N., Nerima, Barbara, De Koning, Harry P., Mäser, Pascal, Barrett, Michael P., Matovu, Enock

Human African trypanosomiasis (HAT) manifests as a chronic infection caused by Trypanosoma brucei gambiense, or as a more acute form due to T. b. rhodesiense. Both manifestations occur in Uganda and...