Ca2�-induced Ca2 � release (CICR) from the sarcoplasmic reticulum (SR) is the cornerstone of cardiac excitation-contraction coupling and Ca2 � signaling. 1,2 However, as an amplification...
Cardioactive Steroids, Markus Keller, Christophe Pignier, Marcel Egger, Ernst Niggli
F90927 is a newly developed cardioactive drug with a steroid-like structure. It acts directly and agonistically on the cardiac L-type Ca 2+ channel by shifting its voltagedependent activation toward...
Na Current In, Marcel Egger, Ernst Niggli
Ca 2+ signals in cardiac muscle cells are composed of spatially limited elementary events termed Ca 2+ sparks. Several studies have also indicated that Ca 2+ signals smaller than Ca 2+ sparks can be...
HISTORICAL REVIEW The early years of cellular cardiac electrophysiology and (2008)
Silvio Weidmann, André G. Kléber, Ernst Niggli, John A. S. Mcguigan Md, Silvio Weidmann
recorded the first intracellular cardiac action potential of a false tendon from the right ventricular endocardium of a dog heart by means of glass microelectrodes. 1 This event marked the beginning...
Jung, Carole, Martins, Adriano S., Niggli, Ernst, Shirokova, Natalia
Aims Cardiac myopathies are the second leading cause of death in patients with Duchenne and Becker muscular dystrophy, the two most common and severe forms of a disabling striated muscle disease....
Ca 2+ Sparks in Cardiac Muscle: Is There Life Without Them? (2007)
The discovery of elementary Ca 2+ signaling events, the Ca 2+ sparks, has profoundly changed our view of cardiac Ca 2+ signaling and, in particular, excitationcontraction coupling. In addition, a...
Involvement of Calcium in Rhythmic Activity Induced by (2007)
Disinhibition In Cultured, Pascal Darbon, Christophe Pignier, Christophe Pignier, Ernst Niggli, Ernst Niggli, ...
this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate...
Jung, Carole, Martins, Adriano S., Niggli, Ernst, Shirokova, Natalia
Aims Cardiac myopathies are the second leading cause of death in patients with Duchenne and Becker muscular dystrophy, the two most common and severe forms of a disabling striated muscle disease....
Calcium waves driven by "sensitization" wave-fronts (2007)
Keller, Markus, Kao, Joseph P.Y., Egger, Marcel, Niggli, Ernst
Objective: Cellular Ca2+ waves are understood as reaction–diffusion systems sustained by Ca2+-induced Ca2+ release (CICR) from Ca2+ stores. Given the recently discovered sensitization of Ca2+...
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle (2006)
Christophe Pignier, Markus Keller, Bruno Vié, Bernard Vacher, Maurice Santelli, Ernst Niggli, ...
Atsuya Momotake, Nicolas Lindegger, Ernst Niggli, Robert J Barsotti, Graham C R Ellis-Davies
Egger, Marcel, Porzig, Hartmut, Niggli, Ernst, Schwaller, Beat
Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na⁺–Ca²⁺ exchanger (NCX1) to correlate suppression of the Na⁺–Ca²⁺...
Egger, Marcel, Porzig, Hartmut, Niggli, Ernst, Schwaller, Beat
Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na⁺–Ca²⁺ exchanger (NCX1) to correlate suppression of the Na⁺–Ca²⁺...
photolysis of caged Ca 2+ (2005)
Nicolas Lindegger, Ernst Niggli
after β-adrenergic stimulation revealed by two-photon
2.1. Why is the elementary nature of Ca 2+ signaling important? 2.2. Why is the precise number of channels participating in the generation of Ca 2+ sparks important?
Myocardial Infarction, Ana Maria Gomez, Beat Schwaller, Hartmut Porzig, Guy Vassort, Ernst Niggli, ...
Hypertrophied and failing cardiac myocytes generally show alterations in intracellular Ca handling associated with changes in the contractile function and arrhythmogenicity. The cardiac Na exchange...
Anushka Michailova, Franco DelPrincipe, Marcel Egger, Ernst Niggli, Myof Myofibrillar Space, Ryr Ryanodine Receptor, ...
Ca signaling in cells is largely governed by Ca diffusion and Ca binding to mobile and stationary Ca buffers, including organelles. To examine Ca signaling in cardiac atrial myocytes, a mathematical...
Mechanische Kontraktion und Relaxation in Herzmuskeleinzelzellen / (1993)
Habschr. Bern (kein Austausch).
Mit Zusfassung
Aus: Schweizerische Mineral. u. petrograph. Mitteilungen. Bd 24. 1944, H. 1/2
Michailova, Anushka, DelPrincipe, Franco, Egger, Marcel, Niggli, Ernst
Ca(2+) signaling in cells is largely governed by Ca(2+) diffusion and Ca(2+) binding to mobile and stationary Ca(2+) buffers, including organelles. To examine Ca(2+) signaling in cardiac atrial...
Lindegger, Nicolas, Niggli, Ernst
In heart muscle the amplification and shaping of Ca2+ signals governing contraction are orchestrated by recruiting a variable number of Ca2+ sparks. Sparks reflect Ca2+ release from the sarcoplasmic...
Michailova, Anushka, DelPrincipe, Franco, Egger, Marcel, Niggli, Ernst
Ca(2+) signaling in cells is largely governed by Ca(2+) diffusion and Ca(2+) binding to mobile and stationary Ca(2+) buffers, including organelles. To examine Ca(2+) signaling in cardiac atrial...
Lindegger, Nicolas, Niggli, Ernst
In heart muscle the amplification and shaping of Ca2+ signals governing contraction are orchestrated by recruiting a variable number of Ca2+ sparks. Sparks reflect Ca2+ release from the sarcoplasmic...
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle
Pignier, Christophe, Keller, Markus, Vié, Bruno, Vacher, Bernard, Santelli, Maurice, Niggli, Ernst, ...
Here we report a novel steroid-like compound F90363, exhibiting positive inotropy in vivo and in vitro in various cardiac muscle preparations.F90363 is a racemic mixture composed of the stereoisomers...
In cardiac muscle, ‘Ca2+ sparks’ have been proposed to underlie Ca2+-induced Ca2+ release (CICR), and to result from openings of clusters of Ca2+ channels (ryanodine receptors; RyRs) located in...
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line
Assandri, Roberta, Egger, Marcel, Gassmann, Max, Niggli, Ernst, Bauer, Christian, Forster, Ian, ...
Recent investigations have shown that the glycoprotein erythropoietin (Epo) and its specific receptor (EpoR) are present in the mammalian brain including human, monkey and mouse. These findings...
The Na+-Ca2+ exchange is a major pathway for removal of cytosolic Ca2+ in cardiac myocytes. It is known to be inhibited by changes of intracellular pH that may occur, for example, during ischaemia....
DelPrincipe, Franco, Egger, Marcel, Niggli, Ernst
In the present study Ca2+ entry via different voltage-dependent membrane channels was examined with a fluorescent Ca2+ indicator before and after β-adrenergic stimulation.To clearly distinguish...
Lipp, Peter, Egger, Marcel, Niggli, Ernst
Ca2+ signals in cardiac muscle cells are composed of spatially limited elementary events termed Ca2+ sparks. Several studies have also indicated that Ca2+ signals smaller than Ca2+ sparks can be...
Modulation of the Local SR Ca2+ Release by Intracellular Mg2+ in Cardiac Myocytes
Gusev, Konstantin, Niggli, Ernst
In cardiac muscle, Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) defines the amplitude and time course of the Ca2+ transient. The global elevation of the intracellular Ca2+...